Browsing by Author "Parlak, Yasemin"

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    Terbium-161 PSMA Therapy in mCRPC Patient Based on an Optimized Radiolabeling Protocol
    (Springer, 2025) Sezgin, Ceren; Uygur, Emre; Parlak, Yasemin; Karatay, Busra; Barutca, Sabri; Dirican, Ahmet; Gumuser, Gul
    This study presents a novel radiolabeling technique for [161Tb]-PSMA-617 in metastatic castration-resistant prostate cancer (mCRPC). The research focused on assessing the radiochemical yield, in vivo stability, and pharmacokinetics of [116 Tb]-PSMA-617 in a clinical setting. Using a sodium acetate buffer and ascorbic acid, a high radiochemical yield (97.98% +/- 2.01) was achieved, ensuring stability and purity. The therapy was evaluated to a 77-year-old mCRPC patient resistant to [177Lu]-PSMA-617, showing favorable biodistribution and urinary excretion. Despite initial stability, disease progression occurred, with a TP53 mutation identified via liquid biopsy. While the method holds promise for targeted radionuclide therapy, resistance mechanisms remain a challenge, necessitating further research for optimized patient selection and treatment strategies.