Browsing by Author "Sulucay, Aysu"

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Citation - Scopus: 3
Diagnosis of Bipolar Disease Using Correlation-Based Feature Selection With Different Classification Methods
(IEEE, 2019) Cigdem, Ozkan; Sulucay, Aysu; Yilmaz, Arif; Oguz, Kaya; Demirel, Hasan; Kitis, Omer; Eker, Cagdas
Three-Dimensional Magnetic Resonance Imaging (3D-MRI) and Computer-Aided Detection (CAD) have been widely studied in the detection of bipolar disorder (BD). In this study, the structural alterations at the grey matter (GM) and white matter (WM) of BD subjects versus healthy controls (HCs) have been compared using Voxel-Based Morphometry (VBM). In order to obtain 3D GM and WM masks, the two sample t-test method and total intracranial volumes of BD and HC as a covariate have been utilized. In addition to analyzing effects of GM and WM tissue maps separately in the detection of BD, impacts of both GM and WM ones are studied by concatenating them in a matrix. The correlation-based feature selection (CFS) feature ranking method is applied to the obtained 3D masks to rank the features, the number of selected top-ranked features are determined using a Fisher criterion (FC) approach, and different classification algorithms are used to classify BD apart from HCs. In this study, 26 BDs and 38 HCs data are used. The experimental results indicate that the classification accuracy of Naive Bayes outperforms the other four classification algorithms used in this study. Additionally, concatenation of GM and WM tissue maps enhances the classification performances of using GM-only and WM-only ones. The classification accuracies obtained for GM, WM, and their concatenation are 72.92%, 78.33%, and 80.00% respectively.
Citation - WoS: 1
Citation - Scopus: 3
Effects of Covariates on Classification of Bipolar Disorder Using Structural Mri
(IEEE, 2019) Cigdem, Ozkan; Horuz, Erencan; Soyak, Refik; Aydeniz, Burhan; Sulucay, Aysu; Oguz, Kaya; Demirel, Hasan
Three-Dimensional Magnetic Resonance Imaging (3D-MRI) and Computer-Aided Detection (CAD) have been widely studied in the detection and diagnosis of neuroanatomical abnormalities, including bipolar disorder (BD). Pre-processing of 3D-MRI scans plays an important role in post-processing. In this study, Voxel-Based Morphometry (VBM) is used to compare the morphological differences at the grey matter (GM) and white matter (WM) of BD subjects versus healthy controls (HCs). The effects of using different covariates (i.e. total intracranial volume (TIV), age, sex, and their combinations) on classification of BDs from HCs have been investigated for GM-only, WM-only, and their combination. 3D masks for GM and WM are generated separately by using local differences between BPs and HCs and the two sample t-test method. Principle component analysis based dimensionality reduction and support vector machine with Gaussian kernel are employed for classification of 26 BDs and 38 HCs obtained from Ege University, School of Medicine, Department of Psychiatry. The results indicate that using only TIV as a covariate provides more robust results for BD classification compared to other covariate combinations. Furthermore, the combination of GM and WM improves classification performance. The highest classification accuracies obtained for GM, WM, and their combination are 70.30%, 79.70%, and 82.80% respectively.