Browsing by Author "Uguz, Alper"

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Evaluation of Donor Exclusions for Living Donor Liver Transplantation in a Tertiary Center
(Elsevier Science Inc, 2026) Gumus, Tufan; Umman, Veysel; Sertoz, Berk; Guler, Ezgi; Uguz, Alper; Sertoz, Ozen Onen; Emre, Sukru
Introduction. The success of living donor liver transplantation is closely related to donor selection. Living donor liver transplantation (LDLT) plays a crucial role in saving lives, especially where cadaveric donations are limited. Donor selection is pivotal for the success of LDLT, emphasizing donor rights, minimizing complications, and ensuring donor survival. The main purpose for donor evaluation is to provide a suitable graft for the recipient while assuring a safe operation for the donor. This study aims to identify our center's donor exclusion reasons, assess limitations in donor pool utilization, and enhance its effectiveness. Methods. We retrospectively analyzed data from 680 healthy individuals who applied as liver donor candidates to our center between November 2016 and November 2021. Of these, 170 underwent donor hepatectomy, while 510 candidates deemed unsuitable were investigated. Results. A total of 170 (25%) candidates became liver donors (group A), and 510 (75%) candidates were found unsuitable (group B). Recipient-related reasons (179, 35.09%) made up the leading exclusion cause. Psychiatric problems (105, 20%) ranked second among the reasons for rejection of donor candidates, and hepatosteatosis was the third most common reason. Conclusion. The critical factor determining the success of living donor liver transplantation is the precise selection of the donor. Achieving optimal donor selection is feasible through a comprehensive multidisciplinary liver transplant team and clearly defined criteria. By employing appropriate selection standards and a skilled transplant team, it is feasible to enhance the pool of liver donors and conduct more living donor liver transplants with reduced morbidity and mortality rates.
Citation - WoS: 7
Citation - Scopus: 8
Solid Pseudopapillary Neoplasms of the Pancreas: Case Series With a Review of the Literature
(Aves, 2020) Uguz, Alper; Unalp, Omer Vedat; Akpinar, Goksever; Karaca, Can Avni; Oruc, Nevin; Nart, Deniz; Yilmaz, Funda
Background/Aims: The solid pseudopapillary neoplasms are quite rare tumors of the pancreas, comprising roughly 1-2% of all pancreatic neoplasms. It has a low malignant potential and usually affects young females. Despite increasing number of articles in the last decade, there is still debate on the pathogenesis, malignant potential and optimal surgical strategy for the solid pseudopapillary neoplasms. Materials and Methods: Medical recordings of 326 patients who were operated due to pancreatic mass were retrospectively analyzed. Patient demographics, presenting symptoms, surgical and pathologic characteristics of the tumor, postsurgical course, long-term survival, and other relevant data were extracted from patients' charts. Results: Majority of the patients were female in consistency with the classic data in the literature. All the patients underwent curative intent resections. Tumors were commonly localized in the tail of the pancreas making distal pancreatectomy the most commonly performed surgical procedure. Mean tumor diameter was 5.8 centimeters with tumor sizes ranging from 1 to 19 cm. Conclusion: The solid pseudopapillary neoplasms of the pancreas is a rare tumor with low malignant potential, which is more common in females of reproductive age, with abdominal pain being their most common presentation. The short-term outcomes in patients following surgical R0 resection are excellent. However, proximal placement of the tumor and female gender may have slightly worse prognosis. We hope that our findings from a series of patients represent a contribution to the existing literature on SPN, and authors declare their willingness to provide further details for future meta-analyses.