Browsing by Author "Urkmez, Aylin Sendemir"

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Citation - WoS: 24
Citation - Scopus: 27
Crosslinking of Poly(vinyl Alcohol) Nanofibres With Polycarboxylic Acids: Biocompatibility With Human Skin Keratinocyte Cells
(Springer, 2017) Cay, Ahmet; Kumbasar, E. Perrin Akcakoca; Keskin, Zalike; Akduman, Cigdem; Urkmez, Aylin Sendemir
In this study, poly(vinyl alcohol) nanofibres were produced and evaluated for wound dressing applications. However, the solubility of the poly(vinyl alcohol) matrix in the aqueous medium generally limits its applications. To overcome this problem, 1,2,3,4 butanetetracarboxylic acid (BTCA) and citric acid (CA) were used as crosslinking agents. Successful bead-free nanofibres were produced, and they both preserved their fibrous structure after water treatment. The mean fibre diameters of polycarboxylic acid crosslinked nanofibres were lower compared to pure PVA nanofibres. Although the morphology of BTCA and CA crosslinked nanofibres was similar, the swelling degree of PVA/CA was found to be higher. Furthermore, toxicity and keratinocyte cell proliferation performance of produced PVA/BTCA and PVA/CA nanofibres indicated that these nanofibrous materials could be used in wound dressing applications.
Citation - WoS: 67
Citation - Scopus: 79
Novel Keratin Modified Bacterial Cellulose Nanocomposite Production and Characterization for Skin Tissue Engineering
(Elsevier, 2017) Keskin, Zalike; Urkmez, Aylin Sendemir; Hames, E. Esin
As it is known that bacterial cellulose (BC) is a biocompatible and natural biopolymer due to which it has a large set of biomedical applications. But still it lacks some desired properties, which limits its uses in many other applications. Therefore, the properties of BC need to be boosted up to an acceptable level. Here in this study for the first time, a new natural nanocomposite was produced by the incorporating keratin (isolated from human hair) to the BC (produced by Acetobacter xylinum) to enhance dermal fibroblast cells' attachment. Two different approaches were used in BC based nanocomposite production: in situ and post modifications. BC/keratin nanocomposites were characterized using SEM, FTIR, EDX, XRD, DSC and XPS analyses. Both production methods have yielded successful results for production of BC based nanocomposite-containing keratin. In vitro cell culture experiments performed with human skin keratinocytes and human skin fibroblast cells indicate the potential of the novel BC/keratin nanocomposites for use in skin tissue engineering. (C) 2017 Elsevier B.V. All rights reserved.