Browsing by Author "Uzunlar, Hakan"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Article
    Citation - WoS: 12
    Citation - Scopus: 12
    Reduced Power and Phase-Locking Values Were Accompanied by Thalamus, Putamen, and Hippocampus Atrophy in Parkinson?s Disease With Mild Cognitive Impairment: an Event-Related Oscillation Study
    (Elsevier Science Inc, 2023) Hunerli-Gunduz, Duygu; Isbitiren, Yagmur Ozbek; Uzunlar, Hakan; Cavusoglu, Berrin; Colakoglu, Berril Donmez; Adag, Emel; Yener, Görsev
    Parkinson's disease (PD) is a multifaceted neurodegenerative disorder accompanied by mild cognitive im-pairment (MCI) as a crucial nonmotor manifestation. Event-related oscillations (EROs) are suggested to re-flect cognitive status associated with subcortical structures in neurodegenerative conditions. In this study, 36 individuals with PD-MCI and 32 PD-CN were compared with 60 healthy control (HC) participants us-ing visual EROs by measures of event-related spectral perturbation and inter-trial coherence, along with subcortical gray matter volumes based on the FIRST algorithm. Cross-correlations among electrophysio-logical, neuropsychological, and structural parameters were investigated exploratively. Both PD-MCI and PD-CN patients had diminished delta and alpha phase-locking than HC, however, electrophysiological ab-normalities were more pronounced in PD-MCI over frontal, central, parietal, and temporal locations in almost all frequency bands, accompanied by bilateral thalamus, hippocampus, and right putamen atro-phy. PD-CN had lower hippocampal volumes than HC, without exhibiting any subcortical differences from PD-MCI. Lastly, EROs showed low-to-high correlations with structural and neuropsychological measures. These findings may highlight the complex interplay between electrophysiological, neuropsychological, and structural parameters in detected abnormalities of PD-CN and PD-MCI. (c) 2022 Elsevier Inc. All rights reserved.