Özgür, Merve

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Profile URL
https://hdl.handle.net/20.500.14365/6940
Name Variants
Ozgur, Merve
Erat, Merve Özgür
Özgür Erat, Merve
Job Title
Email Address
merve.erat@ieu.edu.tr
Main Affiliation
09.01. Basic Medical Sciences
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Current Staff
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ORCID ID
0000-0002-0909-8433
Scopus Author ID
56650787900
Turkish CoHE Profile ID
CF8FC1F9A77111DB
Google Scholar ID
WoS Researcher ID
KQT-8963-2024
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Merve_Ozgur.png (43.53 KB)

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9

Scopus Citation Count

9

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Annals of Neuroscıences1
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    Article
    Citation - WoS: 9
    Citation - Scopus: 9
    The Effects of Optogenetic Activation of Astrocytes on Spike-And Discharges in Genetic Absence Epileptic Rats
    (Sage Publications Ltd, 2022) Ozgur, Merve; Ozyurt, Mustafa Gorkem; Arkan, Sertan; Cavdar, Safiye
    Background: Absence seizures (petit mal seizures) are characterized by a brief loss of consciousness without loss of postural tone. The disease is diagnosed by an electroencephalogram (EEG) showing spike-wave discharges (SWD) caused by hypersynchronous thalamocortical (TC) oscillations. There has been an explosion of research highlighting the role of astrocytes in supporting and modulating neuronal activity. Despite established in vitro evidence, astrocytes' influence on the TC network remains to be elucidated in vivo in the absence epilepsy (AE). Purpose: In this study, we investigated the role of astrocytes in the generation and modulation of SWDs. We hypothesize that disturbances in astrocytes' function may affect the pathomechanism of AE. Methods: To direct the expression of channelrhodopsin-2 (ChR2) rAAV8-GFAP-ChR2(H134R)-EYFP or to control the effect of surgical intervention, AAV-CaMKIIa-EYFP was injected into the ventrobasal nucleus (VB) of the thalamus of 18 animals. After four weeks following the injection, rats were stimulated using blue light (similar to 473 nm) and, simultaneously, the electrophysiological activity of the frontal cortical neurons was recorded for three consecutive days. The animals were then perfused, and the brain tissue was analyzed by confocal microscopy. Results: A significant increase in the duration of SWD without affecting the number of SWD in genetic absence epileptic rats from Strasbourg (GAERS) compared to control injections was observed. The duration of the SWD was increased from 12.50 +/- 4.41 s to 17.44 +/- 6.07 following optogenetic stimulation in GAERS. The excitation of the astrocytes in Wistar Albino Glaxo Rijswijk (WAG-Rij) did not change the duration of SWD; however, stimulation resulted in a significant increase in the number of SWD from 18.52 +/- 11.46 bursts/30 min to 30.17 +/- 18.43 bursts/30 min. Whereas in control injection, the duration and the number of SWDs were similar at pre- and poststimulus. Both the background and poststimulus average firing rates of the SWD in WAG-Rij were significantly higher than the firing recorded in GAERS. Conclusion: These findings suggest that VB astrocytes play a role in modulating the SWD generation in both rat models with distinct mechanisms and can present an essential target for the possible therapeutic approach for AE.