Clinically Silent MRI Lesions in RRMS: Prognostic Impact and An Emulated Trial of Disease Modifying Therapy Escalation

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dc.contributor.author Daruwalla, Cyrus
dc.contributor.author Kremler, Courtney
dc.contributor.author Patti, Francesco
dc.contributor.author Libertinova, Jana
dc.contributor.author Ozakbas, Serkan
dc.contributor.author Peterka, Marek
dc.contributor.author Brown, William
dc.date.accessioned 2026-02-25T15:07:44Z
dc.date.available 2026-02-25T15:07:44Z
dc.date.issued 2025
dc.identifier.doi 10.1136/jnnp-2025-ABN.247
dc.identifier.issn 0022-3050
dc.identifier.issn 1468-330X
dc.identifier.uri https://doi.org/10.1136/jnnp-2025-ABN.247
dc.identifier.uri https://hdl.handle.net/20.500.14365/8681
dc.language.iso en en_US
dc.publisher BMJ Publishing Group en_US
dc.relation.ispartof Journal of Neurology Neurosurgery and Psychiatry en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.title Clinically Silent MRI Lesions in RRMS: Prognostic Impact and An Emulated Trial of Disease Modifying Therapy Escalation en_US
dc.type Conference Object en_US
dspace.entity.type Publication
gdc.collaboration.industrial false
gdc.description.department İzmir Ekonomi Üniversitesi en_US
gdc.description.departmenttemp [Daruwalla, Cyrus; Kremler, Courtney; Tolkovsky, Aviva; Coles, Alasdair; Brown, William] Univ Cambridge, Dept Clin Neurosci, Cambridge, England; [Daruwalla, Cyrus] Addenbrookes Hosp, Cambridge, England; [Patti, Francesco] Dept Med & Surg Sci & Adv Technol GF Ingrassia, Catania, Italy; [Patti, Francesco] Univ Catania, Multiple Sclerosis Unit, AOU Policlin G Rodolico San Marco, Catania, Italy; [Libertinova, Jana] Charles Univ Prague, Prague, Czech Republic; [Libertinova, Jana] Motol Univ Hosp, Fac Med 2, Dept Neurol, Prague, Czech Republic; [Ozakbas, Serkan] Izmir Univ Econ, Med Point Hosp, Izmir, Turkiye; [Peterka, Marek] Charles Univ Prague, Plzen, Czech Republic; [Peterka, Marek] Univ Hosp Plzen, Fac Med Pilsen, Dept Neurol, Plzen, Czech Republic; [Peterka, Marek] Charles Univ Prague, Dept Neurol, Fac Med Hradec Kralove, Hradec Kralove, Czech Republic; [Peterka, Marek] Univ Hosp, Hradec Kralove, Czech Republic; [Vachova, Marta] Gen Univ Hosp, Fac Med 1, Dept Neurol, Prague, Czech Republic; [Vachova, Marta] First Fac Med, Ctr Clin Neurosci, Prague, Czech Republic; [Vachova, Marta] Hosp Teplice, KZ As, Dept Neurol, Teplice, Czech Republic; [Scott, Jeannette Lechner] John Hunter Hosp, Hunter New England Hlth, Newcastle, NSW, Australia; [Roos, Izanne; Kalincik, Tomas; Brown, William] Univ Melbourne, Clin Outcomes Res Unit CORe, Melbourne, Vic, Australia; [Roos, Izanne; Kalincik, Tomas] Royal Melbourne Hosp, Neuroimmunol Ctr, Dept Neurol, Melbourne, Australia; [Foschi, Matteo] S Maria Croci Hosp, Dept Neurosci, Neurol Unit, AUSL Romagna,MS Ctr, Ravenna, Italy; [Foschi, Matteo] Univ Aquila, Dept Biotechnol & Appl Clin Sci DISCAB, Laquila, Italy; [Surcinelli, Andrea] S Maria Croci Hosp Ravenna, Dept Neurosci, Neurol Unit, MS Ctr, Ravenna, Italy; [Neri, Stefano] S Maria Croci Hosp Ravenna, Dept Diagnost Imaging, AUSL Romagna, Ravenna, Italy; [Khoury, Samia] Amer Univ Beirut, Med Ctr, Nehme & Therese Tohme Multiple Sclerosis Ctr, Beirut, Lebanon; [Butzkueven, Helmut] Alfred Hosp, Dept Neurol, Melbourne, Australia; [Butzkueven, Helmut] Monash Univ, Sch Translat Med, Dept Neurosci, Melbourne, Australia; [Meca-Lallana, Jose E.] Virgen de la Arrixaca Clin Univ Hosp, Multiple Sclerosis CSUR & Clin Neuroimmunol Unit, Neurol Dept, Murcia, Spain; [Meca-Lallana, Jose E.] UCAM San Antonio Catholic Univ, Murcia, Spain; [Rous, Zuzana] Palacky Univ Olomouc, Olomouc, Czech Republic; [Rous, Zuzana] Univ Hosp Olomouc, Fac Med & Dent, Dept Neurol, Olomouc, Czech Republic; [Habek, Mario] Univ Hosp Ctr Zagreb, Dept Neurol, Zagreb, Croatia; [Habek, Mario] Univ Zagreb, Sch Med, Zagreb, Croatia; [Alroughani, Raed] Amiri Hosp, Dept Med, Div Neurol, Sharq, Kuwait; [Blanco, Yolanda] Hosp Clin Barcelona, Ctr Neuroimmunol, Serv Neurol, Barcelona, Spain; [Laureys, Guy] Univ Hosp Ghent, Dept Neurol, Ghent, Belgium; [Buzzard, Katherine] Box Hill Hosp, Dept Neurosci, Box Hill, Vic, Australia; [Buzzard, Katherine] Monash Univ, Eastern Hlth Clin Sch, Box Hill, Australia; [Skibina, Olga] Box Hill Hosp, Dept Neurol, Melbourne, Australia; [Skibina, Olga] Monash Univ, Eastern Hlth Clin Sch, Dept Neurosci, Melbourne, Australia; [Gray, Orla] South Eastern HSC Trust, Belfast, Antrim, North Ireland; [Mccombe, Pamela] Univ Queensland, Brisbane, Australia; [Mccombe, Pamela] Royal Brisbane & Womens Hosp, Brisbane, Australia; [Ayuso, Guillermo Izquierdo] Hosp Univ Virgen Macarena, Seville, Spain; [Eichau, Sara] Hosp Univ Virgen Macarena, Dept Neurol, Seville, Spain; [Spitaleri, Daniele La] Azienda Osped Rilievo Nazl San Giuseppe Moscati Av, Avellino, Italy; [Maimone, Davide] ARNAS Garibaldi, UOC Neurol, Ctr Sclerosi Multipla, Catania, Italy; [Prat, Alexandre; Girard, Marc; Duquette, Pierre] CHUM MS Ctr, Montreal, PQ, Canada; [Prat, Alexandre; Girard, Marc; Duquette, Pierre] Univ Montreal, Montreal, PQ, Canada; [Sanchez, Jose Luis] Galdakao Usansolo Univ Hosp, Dept Psychiat, Osakidetza Basque Hlth Serv, Galdakao, Spain; [Sanchez, Jose Luis] Biocruces Bizkaia Hlth Res Inst, Bizkaia, Spain; [Pesch, Vincent Van] Clin Univ St Luc, Brussels, Belgium; [Pesch, Vincent Van] Catholic Univ Louvain, Ottignies Louvain La Neuv, Belgium; [Oh, Jiwon] St Michaels Hosp, Toronto, ON, Canada; [Amato, Maria Pia] Univ Florence, Dept NEUROFARBA, Florence, Italy; [Amato, Maria Pia] IRCCS Fdn Don Carlo Gnocchi, Florence, Italy; [Wijmeersch, Bart Van] Pelt & Hasselt Univ, Univ MS Ctr, Noorderhart Rehabil & MS, Hasselt, Belgium; [Gerlach, O.] Zuyderland Med Ctr, Acad MS Ctr Zuyd, Dept Neurol, Sittard Geleen, Netherlands; [Gerlach, O.] Maastricht Univ, Med Ctr, Sch Mental Hlth & Neurosci, Dept Neurol, Maastricht, Netherlands; [Lugaresi, Alessandra] Univ Bologna, Dipartimento Sci Biomed & Neuromotorie, Bologna, Italy; [Lugaresi, Alessandra] IRCCS Ist Sci Neurol Bologna, Bologna, Italy; [Tomassini, Valentina] Univ G Annunzio Chieti Pescara, Inst Adv Biomed Technol ITAB, Dept Neurosci Imaging & Clin Sci, Chieti, Italy; [Tomassini, Valentina] Ctr Rehabil Disabil & Sports Med CARES, Chieti, Italy; [Tomassini, Valentina] Ss Annunziata Univ Hosp, Clin Neurol, MS Ctr, Chieti, Italy; [Hodgkinson, Suzanne] UNSW, Ingham Inst Appl Med Res, Immune Tolerance Lab, Sydney, NSW, Australia; [Hodgkinson, Suzanne] UNSW, Dept Med, Sydney, NSW, Australia; [Hradilek, Pavel] Univ Hosp Ostrava, Dept Neurol, Ostrava, Czech Republic; [Dufek, Michal] Masaryk Univ, St Annes Univ Hosp, Dept Neurol 1, Brno, Czech Republic; [Messina, Silvia] Frimley Pk Hosp, Dept Vasc Surg, Frimley, England; [Taylor, Bruce] Royal Hobart Hosp, Hobart, Australia; [Foong, Yi Chao] Royal Hobart Hosp, MS Res Flagship, Hobart, Australia; [Foong, Yi Chao] Royal Hobart Hosp, Tasmanian Hlth Serv, Hobart, Tas, Australia; [Foong, Yi Chao] Monash Univ, Sch Translat Med, Melbourne, Australia; [Cardenas-Robledo, Simon] Hosp Univ Nacl Colombia Bogota, Ctr Esclerosis Multiple CEMHUN, Dept Neurol, Bogota, Colombia; [Cartechini, Elisabetta] AST Macerata, Neurol Unit, Macerata, Italy; [John, Nevin A.] Monash Univ, Sch Clin Sci, Dept Med, Clayton, Vic, Australia; [John, Nevin A.] Monash Hlth, Dept Oncol, Clayton, Australia; [Macdonell, Richard] Austin Hlth, Melbourne, Australia; [D'amico, Emanuele] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy; [Willekens, Barbara] Antwerp Univ Hosp, Dept Neurol, Edegem, Belgium; [Willekens, Barbara] Univ Antwerp, Translat Neurosci Res Grp, Fac Med & Hlth Sci, Antwerp, Belgium; [Willekens, Barbara] Univ Antwerp, Fac Med & Hlth Sci, Lab Expt Hematol, Antwerp, Belgium; [Garber, Justin] Westmead Hosp, Sydney, Australia; [Terzi, Murat] Mayis Univ, Med Fac, Samsun, Turkiye; [Massey, Jennifer] St Vincents Hosp, Sydney, Australia; [Houskova, Jana] Hosp Ceske Budejovice, Dept Neurol, Ceske Budejovice, Czech Republic; [Lapointe, Emmanuelle] Ctr Hosp Univ Sherbrooke, Sherbrooke, PQ, Canada; [Stetkarova, Ivana] Charles Univ & Hosp Kralovske Vinohrady, Fac Med 3, Dept Neurol, Prague 10000 10, Czech Republic; [Al-Asmi, Abdullah] Sultan Qaboos Univ, Coll Med & Hlth Sci, Al Khoud, Oman; [Al-Asmi, Abdullah] Sultan Qaboos Univ Hosp, Al Khoud, Oman; [Barnett, Michael] Brain & Mind Ctr, Sydney, Australia; [Slee, Mark] Flinders Univ Australia, Coll Med & Publ Hlth, Adelaide, Australia; [Guimaraes, Joana] Univ Porto, Fac Med, Dept Clin Neurosci & Mental Hlth, Unidade Local Saude Sao Joao, Porto, Portugal; [Csepany, Tunde] Univ Debrecen, Fac Med, Dept Neurol, Debrecen, Hungary; [Gouider, Riadh; Mrabet, Saloua] Razi Univ Hosp, Clin Invest Ctr Neurosci & Mental Hlth, Dept Neurol, Tunis, Tunisia; [Gouider, Riadh; Mrabet, Saloua] Univ Tunis El Manar, Fac Med Tunis, Tunis, Tunisia; [Yammout, Bassem] Harley St Med Ctr, Neurol Inst, Abu Dhabi, U Arab Emirates; [Yammout, Bassem] Harley St Med Ctr, MS Ctr, Abu Dhabi, U Arab Emirates; [Kuhle, Jens] Univ Hosp, Basel, Switzerland; [Kuhle, Jens] Univ Basel, Dept Neurol, Basel, Switzerland; [Kuhle, Jens] Univ Hosp, Multiple Sclerosis Ctr, Basel, Switzerland; [Kuhle, Jens] Univ Hosp, Res Ctr Clin Neuroimmunol & Neurosci RC2NB, Basel, Switzerland; [Kuhle, Jens] Univ Hosp, Dept Biomed, Basel, Switzerland; [Kuhle, Jens] Univ Hosp, Dept Clin Res, Basel, Switzerland; [Gross-Paju, Katrin] TalTech, Tallinn, Estonia; [Castillo-Trivino, Tamara] Hosp Univ Donostia, San Sebastian, Spain; [Castillo-Trivino, Tamara] IIS Biodonostia, San Sebastian, Spain; [Kerrigan, Simon] East Suffolk & North Essex NHS Fdn Trust, Ipswich Hosp, Dept Neurol, Ipswich, Suffolk, England; [Madley-Dowd, Paul; Sterne, Jonathan] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England; [Brown, William] UCL, Dept Neuroinflammat, Queen Sq Multiple Sclerosis Ctr, NMR Res Unit,Queen Sq Inst Neurol, London, England en_US
gdc.description.endpage A77 en_US
gdc.description.issue SUPPL_3 en_US
gdc.description.publicationcategory Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q1
gdc.description.startpage A76 en_US
gdc.description.volume 96 en_US
gdc.description.woscitationindex Science Citation Index Expanded - Conference Proceedings Citation Index - Science
gdc.description.wosquality Q1
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gdc.virtual.author Özakbaş, Serkan
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