Single Silent Lesions Matter: a Comprehensive Assessment of the Prognostic Impact of Clinically Silent MRI Lesions in RRMS, and an Emulated Trial of Treatment Escalation

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dc.contributor.author Daruwalla, Cyrus
dc.contributor.author Kremler, Courtney
dc.contributor.author Patti, Francesco
dc.contributor.author Libertinova, Jana
dc.contributor.author Ozakbas, Serkan
dc.contributor.author Peterka, Marek
dc.contributor.author Brown, William
dc.date.accessioned 2025-12-30T16:02:34Z
dc.date.available 2025-12-30T16:02:34Z
dc.date.issued 2025
dc.identifier.issn 1352-4585
dc.identifier.issn 1477-0970
dc.identifier.uri https://hdl.handle.net/20.500.14365/8566
dc.language.iso en en_US
dc.publisher Sage Publications Ltd en_US
dc.relation.ispartof Multiple Sclerosis Journal en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.title Single Silent Lesions Matter: a Comprehensive Assessment of the Prognostic Impact of Clinically Silent MRI Lesions in RRMS, and an Emulated Trial of Treatment Escalation en_US
dc.type Conference Object en_US
dspace.entity.type Publication
gdc.author.wosid Çeli̇k Soysal, Aysun/Abb-8478-2021
gdc.author.wosid Roos, Izanne/Abo-3767-2022
gdc.author.wosid Neri, Stefano/D-6772-2019
gdc.author.wosid Castillo, Tamara/Abh-4121-2020
gdc.author.wosid Tomassini, Valentina/Hge-0655-2022
gdc.author.wosid Peterka, Marek/Hlg-5642-2023
gdc.author.wosid Boz, Cavit/V-5127-2017
gdc.coar.access metadata only access
gdc.coar.type text::conference output
gdc.description.department İzmir Ekonomi Üniversitesi en_US
gdc.description.departmenttemp [Daruwalla, Cyrus; Kremler, Courtney; Tolkovsky, Aviva; Coles, Alasdair; Brown, William] Univ Cambridge, Dept Clin Neurosci, Cambridge, England; [Daruwalla, Cyrus] Addenbrookes Hosp, Cambridge, England; [Patti, Francesco] GF Ingrassia, Dept Med & Surg Sci & Adv Technol, Catania, Italy; [Patti, Francesco] Univ Catania, AOU Policlin G Rodolico San Marco, Multiple Sclerosis Unit, Catania, Italy; [Libertinova, Jana; Peterka, Marek; Vachova, Marta] Charles Univ Prague, Prague, Czech Republic; [Libertinova, Jana] Motol Univ Hosp, Dept Neurol, Fac Med 2, Prague, Czech Republic; [Ozakbas, Serkan] Izmir Univ Econ, Med Point Hosp, Izmir, Turkiye; [Peterka, Marek] Univ Hosp Plzen, Fac Med Pilsen, Dept Neurol, Plzen, Czech Republic; [Peterka, Marek] Charles Univ Prague, Dept Neurol, Fac Med Hradec Kralove, Hradec Kralove, Czech Republic; [Peterka, Marek] Univ Hosp Hradec Kralove, Hradec Kralove, Czech Republic; [Vachova, Marta] Gen Univ Hosp, Dept Neurol, Prague, Czech Republic; [Vachova, Marta] Gen Univ Hosp, Ctr Clin Neurosci, Fac Med 1, Prague, Czech Republic; [Vachova, Marta] Hosp Teplice, Dept Neurol, KZ As, Teplice, Czech Republic; [Boz, Cavit] Farabi Hosp, KTU Med Fac, Trabzon, Turkiye; [Scott, Jeannette Lechner] Univ Newcastle, Hunter Med Res Inst, Newcastle, Australia; [Scott, Jeannette Lechner] John Hunter Hosp, Hunter New England Hlth, Newcastle, NSW, Australia; [Roos, Izanne; Brown, William] Univ Melbourne, Clin Outcomes Res Unit CORe, Melbourne, Australia; [Roos, Izanne] Royal Melbourne Hosp, Neuroimmunol Ctr, Dept Neurol, Melbourne, Australia; [Foschi, Matteo] AUSL Romagna, S Maria Croci Hosp, Dept Neurosci, MS Ctr,Neurol Unit, Ravenna, Italy; [Foschi, Matteo] Univ Aquila, Dept Biotechnol & Appl Clin Sci DISCAB, Laquila, Italy; [Surcinelli, Andrea] S Maria Croci Hosp Ravenna, Dept Neurosci, MS Ctr, Neurol Unit, Ravenna, Italy; [Neri, Stefano] AUSL Romagna, S Maria Croci Hosp Ravenna, Dept Diagnost Imaging, Ravenna, Italy; [Khoury, Samia] Amer Univ Beirut, Med Ctr, Nehme & Therese Tohme Multiple Sclerosis Ctr, Beirut, Lebanon; [van der Walt, Anneke; Skibina, Olga] Alfred Hosp, Dept Neurol, Melbourne, Australia; [van der Walt, Anneke; Skibina, Olga] Monash Univ, Cent Clin Sch, Dept Neurosci, Melbourne, Australia; [Butzkueven, Helmut] Alfred Hosp, Dept Neurol, Melbourne, Australia; [Butzkueven, Helmut] Monash Univ, Dept Neurosci, Sch Translat Med, Melbourne, Australia; [Meca-Lallana, Jose E.] Virgen Arrixaca Clin Univ Hosp, Multiple Sclerosis CSUR, Murcia, Spain; [Meca-Lallana, Jose E.] Virgen Arrixaca Clin Univ Hosp, Clin Neuroimmunol Unit, Neurol Dept, Murcia, Spain; [Meca-Lallana, Jose E.] San Antonio Catholic Univ, UCAM, Murcia, Spain; [Rous, Zuzana] Palacky Univ Olomouc, Olomouc, Czech Republic; [Rous, Zuzana] Univ Hosp Olomouc, Dept Neurol, Fac Med & Dent, Olomouc, Czech Republic; [Habek, Mario] Univ Hosp Ctr Zagreb, Dept Neurol, Zagreb, Croatia; [Habek, Mario] Univ Zagreb, Sch Med, Zagreb, Croatia; [Grammond, Pierre] CISSS Chaudiere Appalache, Levis, PQ, Canada; [Blanco, Yolanda] Hosp Clin Barcelona, Ctr Neuroimmunol, Serv Neurol, Barcelona, Spain; [Laureys, Guy] Univ Hosp Ghent, Dept Neurol, Ghent, Belgium; [Buzzard, Katherine] Box Hill Hosp, Dept Neurosci, Box Hill, Australia; [Buzzard, Katherine] Monash Univ, Eastern Hlth Clin Sch, Box Hill, Australia; [Skibina, Olga] Box Hill Hosp, Dept Neurol, Melbourne, Australia; [Skibina, Olga] Monash Univ, Eastern Hlth Clin Sch, Dept Neurosci, Melbourne, Australia; [Gray, Orla] South Eastern HSC Trust, Belfast, North Ireland; [Mccombe, Pamela] Univ Queensland, Brisbane, Australia; [Mccombe, Pamela] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia; [Izquierdo Ayuso, Guillermo] Hosp Univ Virgen Macarena, Seville, Spain; [Izquierdo Ayuso, Guillermo] Hosp Univ Virgen Macarena, Seville, Spain; [Eichau, Sara] Hosp Univ Virgen Macarena, Dept Neurol, Seville, Spain; [Spitaleri, Daniele L. A.] Azienda Osped Rilievo Nazl San Giuseppe Moscati A, Avellino, Italy; [Maimone, Davide] ARNAS Garibaldi, Ctr Sclerosi Multipla, UOC Neurol, Catania, Italy; [Girard, Marc; Duquette, Pierre] CHUM MS Ctr, Montreal, PQ, Canada; [Girard, Marc; Duquette, Pierre] Univ Montreal, Montreal, PQ, Canada; [Luis Sanchez, Jose] Galdakao Usansolo Univ Hosp, Osakidetza Basque Hlth Serv, Dept Neurol, Galdakao, Spain; [Luis Sanchez, Jose] Biocruces Bizkaia Hlth Res Inst, Bizkaia, Spain; [Van Pesch, Vincent] Clin Univ St Luc, Brussels, Belgium; [Van Pesch, Vincent] Catholic Univ Louvain, Ottignies, Belgium; [Oh, Jiwon] St Michaels Hosp, Toronto, ON, Canada; [Soysal, Aysun] Bakirkoy Educ & Res Hosp Psychiat & Neurol Dis, Istanbul, Turkiye; [Amato, Maria Pia] Univ Florence, Dept Neurofarba, Florence, Italy; [Amato, Maria Pia] IRCCS Fdn Don Carlo Gnocchi, Florence, Italy; [Gerlach, O.] Pelt & Hasselt Univ, Univ MS Ctr, Noorderhart, Rehabil & MS, Hasselt, Belgium; [Gerlach, O.] Zuyderland Med Ctr, Acad MS Ctr Zuyd, Dept Neurol, Sittard Geleen, Netherlands; [Gerlach, O.] Maastricht Univ, Med Ctr, Dept Neurol, Sch Mental Hlth & Neurosci, Maastricht, Netherlands; [Lugaresi, Alessandra] Univ Bologna, Dipartimento Sci Biomed & Neuromotorie, Bologna, Italy; [Lugaresi, Alessandra] IRCCS Ist Sci Neurol Bologna, Bologna, Italy; [Tomassini, Valentina] Univ G dAnnunzio, Inst Adv Biomed Technol ITAB, Dept Neurosci Imaging & Clin Sci, Chieti, Italy; [Tomassini, Valentina] Ctr Rehabil Disabil & Sport Med CARES, Chieti, Italy; [Tomassini, Valentina] SS Annunziata Univ Hosp, MS Ctr, Neurol Clin, Chieti, Italy; [Hodgkinson, Suzanne] UNSW, Immune Tolerance Lab, Ingham Inst, Sydney, NSW, Australia; [Hodgkinson, Suzanne] UNSW, Dept Med, Sydney, NSW, Australia; [Hradilek, Pavel] Univ Hosp Ostrava, Dept Neurol, Ostrava, Czech Republic; [Dufek, Michal] Masaryk Univ, St Annes Univ Hosp, Dept Neurol 1, Brno, Czech Republic; [Messina, Silvia] Frimley Pk Hosp, Dept Neurol, Frimley, England; [Taylor, Bruce] Royal Hobart Hosp, Hobart, Australia; [Foong, Yi Chao] Royal Hobart Hosp, MS Res Flagship, Hobart, Australia; [Foong, Yi Chao] Royal Hobart Hosp, Tasmanian Hlth Serv, Hobart, Tas, Australia; [Foong, Yi Chao] Monash Univ, Sch Translat Med, Melbourne, Australia; [Cardenas-Robledo, Simon] Hosp Univ Nacl Colombia Bogota, Ctr Esclerosis Mltiple CEMHUN, Dept Neurol, Bogota, Colombia; [Cardenas-Robledo, Simon] Univ Nacl Colombia, Fac Med, Dept Medicina Interna, Bogota, Colombia; [Cartechini, Elisabetta] AST Macerata, Neurol Unit, Macerata, Italy; [John, Nevin A.] Monash Univ, Dept Med, Sch Clin Sci, Clayton, Australia; [John, Nevin A.] Monash Hlth, Dept Neurol, Clayton, Australia; [Macdonell, Richard] Austin Hlth, Melbourne, Australia; [D'Amico, Emanuele] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy; [Willekens, Barbara] Antwerp Univ Hosp, Dept Neurol, Edegem, Belgium; [Willekens, Barbara] Univ Antwerp, Translat Neurosci Res Grp, Fac Med & Hlth Sci, Antwerp, Belgium; [Willekens, Barbara] Univ Antwerp, Fac Med & Hlth Sci, Lab Expt Hematol, Antwerp, Belgium; [Garber, Justin] Westmead Hosp, Sydney, Australia; [Terzi, Murat] 19 Mayis Univ, Med Fac, Samsun, Turkiye; [Massey, Jennifer] St Vincents Hosp, Sydney, Australia; [Houskova, Jana] Hosp Ceske Budejovice, Dept Neurol, Ceske Budejovice, Czech Republic; [Lapointe, Emmanuelle] Ctr Hosp Univ Sherbrooke, Sherbrooke, PQ, Canada; [Stetkarova, Ivana] Hosp Kralovske Vinohrady, Dept Neurol, Fac Med 3, Prague, Czech Republic; [Al-Asmi, Abdullah] Sultan Qaboos Univ, Coll Med & Hlth Sci, Al Khoud, Oman; [Al-Asmi, Abdullah] Sultan Qaboos Univ Hosp, Al Khoud, Oman; [Barnett, Michael] Brain & Mind Ctr, Sydney, Australia; [Slee, Mark] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, Australia; [Guimaraes, Joana] Univ Porto, Fac Med, Dept Clin Neurosci & Mental Hlth, Unidade Local Saude Sao Joao, Porto, Portugal; [Csepany, Tunde] Univ Debrecen, Dept Neurol, Fac Med, Debrecen, Hungary; [Gouider, Riadh; Mrabet, Saloua] Razi Univ Hosp, Dept Neurol, Clin Invest Ctr Neurosci & Mental Hlth, Tunis, Tunisia; [Gouider, Riadh; Mrabet, Saloua] Univ Tunis El Manar, Fac Med Tunis, Tunis, Tunisia; [Yammout, Bassem] Harley St Med Ctr, Neurol Inst, Abu Dhabi, U Arab Emirates; [Yammout, Bassem] MS Ctr, Abu Dhabi, U Arab Emirates; [Kuhle, Jens] Univ Hosp, Basel, Switzerland; [Kuhle, Jens] Univ Basel, Dept Neurol, Basel, Switzerland; [Kuhle, Jens] Univ Hosp, Multiple Sclerosis Ctr, Basel, Switzerland; [Kuhle, Jens] Univ Hosp, Res Ctr Clin Neuroimmunol & Neurosci RC2NB, Dept Biomed, Basel, Switzerland; [Kuhle, Jens] Univ Hosp, Res Ctr Clin Neuroimmunol & Neurosci RC2NB, Dept Clin Res, Basel, Switzerland; [Kuhle, Jens] Univ Basel, Basel, Switzerland; [Gross-Paju, Katrin] West Tallinn Cent Hosp, Tallinn, Estonia; [Gross-Paju, Katrin] TalTech, Tallinn, Estonia; [Castillo-Trivino, Tamara] Hosp Univ Donostia, San Sebastian, Spain; [Castillo-Trivino, Tamara] IIS Biodonostia, San Sebastian, Spain; [Kerrigan, Simon] East Suffolk & North Essex NHS Fdn Trust, Ipswich Hosp, Dept Neurol, Ipswich, England; [Madley-Dowd, Paul; Sterne, Jonathan] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England; [Brown, William] Univ Coll London UCL, NMR Res Unit, Queen Sq Multiple Sclerosis Ctr, Queen Sq Inst Neurol, London, England en_US
gdc.description.endpage 384 en_US
gdc.description.issue 3 en_US
gdc.description.publicationcategory Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q1
gdc.description.startpage 380 en_US
gdc.description.volume 31 en_US
gdc.description.woscitationindex Science Citation Index Expanded
gdc.description.wosquality Q1
gdc.identifier.wos WOS:001603659901102
gdc.index.type WoS
gdc.virtual.author Özakbaş, Serkan
gdc.wos.citedcount 0
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