Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14365/1222
Title: | Neurological Soft Signs in Bipolar Disorder in Comparison To Healthy Controls and Schizophrenia: a Meta-Analysis | Authors: | Bora, Emre Akgul, Ozge Ceylan, Deniz Ozerdem, Aysegul |
Keywords: | Neurological soft signs Bipolar disorder Schizophrenia Meta-analysis Systematic review Cognitive Impairment Discriminate Schizophrenia Euthymic Patients I Disorder Brain Morphology Dysfunction Instrument Psychosis Relatives |
Publisher: | Elsevier | Abstract: | Neurological soft signs (NSS) are subtle deficits in motor coordination, sensory integration, and sequencing of complex motor acts. Increased NSS is a well-established feature of patients with schizophrenia but a relatively smaller number of studies have investigated NSS in bipolar disorder (BD). Some authors but not others suggested that NSS can distinguish schizophrenia from BD. We conducted a meta-analysis of 18 studies to quantitatively review NSS in BD in comparison to schizophrenia and healthy controls. The current meta-analysis compared NSS scores of 725 BD patients and 634 healthy controls, and 391 BD and 471 schizophrenia patients. Patients with BD had significantly higher NSS scores (d = 1.14, CI = 0.89-1.44) than healthy controls and increased scores in BD was evident in all aspects of NSS (d = 0.88-0.99). BD was associated with a less severe increase in NSS compared to schizophrenia, however, between-group difference was modest (d = 0.42, CI = 0.18-0.65). The results of this meta-analysis demonstrated that BD is characterized by a robust increase in NSS which is only moderately less severe than schizophrenia. Increased NSS is a common feature of both disorders. (c) 2018 Elsevier B.V. and ECNP. All rights reserved. | URI: | https://doi.org/10.1016/j.euroneuro.2018.08.006 https://hdl.handle.net/20.500.14365/1222 |
ISSN: | 0924-977X 1873-7862 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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