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https://hdl.handle.net/20.500.14365/1369
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baykara, Burak | - |
dc.contributor.author | Koc, Dogukan | - |
dc.contributor.author | Resmi, Halil | - |
dc.contributor.author | Akan, Pinar | - |
dc.contributor.author | Tunca, Zeliha | - |
dc.contributor.author | Ozerdem, Aysegul | - |
dc.contributor.author | Ceylan, Deniz | - |
dc.date.accessioned | 2023-06-16T14:11:22Z | - |
dc.date.available | 2023-06-16T14:11:22Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.issn | 1878-4216 | - |
dc.identifier.uri | https://doi.org/10.1016/j.pnpbp.2020.110075 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14365/1369 | - |
dc.description.abstract | Bipolar disorder (BD) is a heterogeneous disorder that contains neurodevelopmental differences. Defining homogeneous subgroups of BD patients by using age at onset (AAO) as a specifier may promote the classification of biomarkers. This study compares peripheral BDNF levels between pediatric and adult BD patients to investigate the associations between BDNF levels, AAO, and illness duration. We enrolled two groups of euthymic patients, those with pediatric BD (n = 39) and those with adult BD (n = 31), as well as a group of healthy controls (HCs) (n = 90). Participants were assessed using clinical measures and BDNF serum levels were obtained using ELISA. We observed that BDNF levels were comparable between adult BD and HCs, but were clearly lower in pediatric BD than in HCs. In adult BD with AAO ?30 years, BDNF levels were significantly higher than in adult BD with AAO <30 years. In pediatric BD, patients with prepubertal-onset had higher BDNF levels than those with pubertalonset. BDNF levels demonstrated the accuracy of being able to distinguish pediatric BD from healthy controls in a receiver operating characteristic (ROC) curve analysis (area under the curve [AUC] = 0.792). In adult BD, higher BDNF levels were associated with later disease onset, but this was not the case in pediatric BD. Finally, reduced BDNF levels were associated with illness duration in adult BD. The findings indicate that BDNF levels in BD patients are associated with AAO. BDNF may, therefore, potentially serve as a developmental marker in BD, when AAO is taken into account. | en_US |
dc.description.sponsorship | Dokuz Eylul University Scientific Research Projects Coordination Unit, Izmir, Turkey [KB.SAG.039] | en_US |
dc.description.sponsorship | This work was supported by Dokuz Eylul University Scientific Research Projects Coordination Unit, Izmir, Turkey (2019.KB.SAG.039). The funding sources had no role in the study design, data collection, analysis and interpretation of data, writing of the report, and in the decision to submit the article for publication. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
dc.relation.ispartof | Progress in Neuro-Psychopharmacology & Bıologıcal Psychıatry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | BDNF (brain-derived neurotrophic factor) | en_US |
dc.subject | Bipolar disorder | en_US |
dc.subject | Age at onset | en_US |
dc.subject | Early-onset bipolar disorder | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Neuroprogression | en_US |
dc.subject | Rating-Scale | en_US |
dc.subject | Bdnf Levels | en_US |
dc.subject | Factor Gene | en_US |
dc.subject | Serum | en_US |
dc.subject | Neuroprogression | en_US |
dc.subject | Adolescents | en_US |
dc.subject | Reliability | en_US |
dc.subject | Validity | en_US |
dc.subject | Markers | en_US |
dc.subject | Schizophrenia | en_US |
dc.title | Brain-derived neurotrophic factor in bipolar disorder: Associations with age at onset and illness duration | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.pnpbp.2020.110075 | - |
dc.identifier.pmid | 32798619 | en_US |
dc.identifier.scopus | 2-s2.0-85089656501 | en_US |
dc.department | İzmir Ekonomi Üniversitesi | en_US |
dc.authorid | Koc, Dogukan/0000-0002-2309-1051 | - |
dc.authorid | Alşen, Sevay/0000-0003-1064-6115 | - |
dc.authorid | Mesman, Esther/0000-0002-3661-8764 | - |
dc.authorid | AKAN, PINAR/0000-0001-9211-1944 | - |
dc.authorid | Hillegers, Manon/0000-0003-4877-282X | - |
dc.authorid | Ceylan, Deniz/0000-0002-1438-8240 | - |
dc.authorwosid | Koc, Dogukan/AAD-8357-2020 | - |
dc.authorwosid | Alşen, Sevay/HJP-9007-2023 | - |
dc.authorwosid | Ceylan, Deniz/E-9415-2017 | - |
dc.authorwosid | Hillegers, Manon/L-6794-2016 | - |
dc.authorscopusid | 22984138200 | - |
dc.authorscopusid | 57188832846 | - |
dc.authorscopusid | 6506874754 | - |
dc.authorscopusid | 12238984200 | - |
dc.authorscopusid | 6602175079 | - |
dc.authorscopusid | 6602570797 | - |
dc.authorscopusid | 56198886800 | - |
dc.identifier.volume | 108 | en_US |
dc.identifier.wos | WOS:000643710600008 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | reserved | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 09.02. Internal Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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