Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14365/2231
Title: | Normalized Theta but Increased Gamma Activity After Acetylcholinesterase Inhibitor Treatment in Alzheimer's Disease: Preliminary Qeeg Study |
Authors: | Fide, Ezgi Yerlikaya, Deniz Öz, Didem Öztura, İbrahim Yener, Görsev |
Keywords: | acetylcholinesterase inhibitors (AChE-I) Alzheimer's disease (AD) EEG power and coherence gamma band theta band alpha band Quantitative Eeg Cholinesterase Inhibitor Cholinergic Hypothesis Frequency Oscillations Epileptiform Activity Spectral-Analysis Nucleus Basalis Donepezil Memory Rivastigmine |
Publisher: | Sage Publications Inc |
Abstract: | Acetylcholinesterase inhibitors (AChE-I) are the core treatment of mild to severe Alzheimer's disease (AD). However, the efficacy of AChE-I treatment on electroencephalography (EEG) and cognition remains unclear. We aimed to investigate the EEG power and coherence changes, in addition to neuropsychological performance, following a one-year treatment. Nine de-novo AD patients and demographically-matched healthy controls (HC) were included. After baseline assessments, all AD participants started cholinergic therapy. We found that baseline and follow-up gamma power analyzes were similar between groups. Yet, within the AD group after AChE-I intake, individuals with AD displayed higher gamma power compared to their baselines (P < .039). Also, baseline gamma coherence analysis showed lower values in the AD than in HC (P < .048), while these differences disappeared with increased gamma values of AD patients at the follow-up. Within the AD group after AChE-I intake, individuals with AD displayed higher theta and alpha coherence compared to their baselines (all, P < .039). These increased results within the AD group may result from a subclinical epileptiform activity. Even though AChE-I is associated with lower mortality, our results showed a significant effect on EEG power yet can increase the subclinical epileptiform activity. It is essential to be conscious of the seizure risk that treatment may cause. |
URI: | https://doi.org/10.1177/15500594221120723 https://hdl.handle.net/20.500.14365/2231 |
ISSN: | 1550-0594 2169-5202 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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