Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/4680
Title: Serum Claudin-5, Claudin-11, Occludin, Vinculin, Paxillin, and Beta-Catenin Levels in Preschool Children With Autism Spectrum Disorder
Authors: Bilgiç, Ayhan
Ferahkaya, Hursit
Karagöz, Hülya
Kılınç, İbrahim
Energin, Vesile Meltem
Keywords: Autism spectrum disorder
claudin
occludin
beta-catenin
vinculin
paxillin
Zonulin Levels
Blood
Genes
Expression
Behavior
Barrier
Publisher: Taylor & Francis Ltd
Abstract: Aim Increased intestinal and blood-brain barriers (BBB) permeability has been suggested to have a role in autism spectrum disorder (ASD). Claudin-5, claudin-11, occludin, beta-catenin, vinculin, and paxillin are crucial components of these barriers. This study assessed concentrations of these molecules in preschool children with ASD.Methods A total of 80 children with ASD and 40 controls aged 18-60 months were enrolled in this study. Serum levels of biochemical variables were determined using commercial enzyme-linked immunosorbent assay kits.Results Serum claudin-11, occludin, and beta-catenin levels were significantly higher in the ASD group than in the control group. However, no significant difference for serum claudin-5, vinculin, and paxillin levels was detected between the groups.Conclusion These findings suggest that claudin-11, occludin, and beta-catenin may be involved in the pathogenesis of ASD. These proteins may affect the brain by causing dysregulation in intestinal or blood-brain barrier permeability or with other unknown mechanisms.
URI: https://doi.org/10.1080/08039488.2023.2168055
https://hdl.handle.net/20.500.14365/4680
ISSN: 0803-9488
1502-4725
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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