Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/4877
Title: Determination of Eight Hub Genes and Functional Pathways Affecting Both the Survival of Early- and Late-Stage Colon Cancer Patients
Authors: Ayna Duran, Gizem
Sert, Fatma
Keywords: Arginine binding
colon cancer stage
methylcytosine dioxygenase activity
oxidoreductase activity
survival
Arginine
Cells
Enzymes
Tm4sf5
Dna
Publisher: Kare Publ
Abstract: OBJECTIVEThe stage of colon cancer (CC) and therefore the level at which the treatment is initiated affects the survival of CC patients. In our study, we aimed to identify the common survival-related genes in both early-and late-stage CC patients.METHODSInformation on the demographic characteristics of 581 patients and microarray expression profiles (GSE39582) were obtained from the gene expression omnibus database. Survival analysis was per-formed using univariate and multivariate Cox regression methods with the help of R3.53 programming language and Kaplan-Meier graphics through the R software Survival package. ShinyGO v0.741 gene ontology enrichment analysis was performed to clarify the common and functional pathways related to both early-and late-stage CC cancer patients' data.RESULTSCox regression analysis indicated that overall survival and relapse-free survival of CC patients were strongly influenced by stage. Genes that significantly affect prognosis and survival in early-and late -stage CC patients were identified. As a result of gene enrichment analysis, arginine binding, oxidore-ductase activity, and methylcytosine dioxygenase activity and related eight hub genes (TM4SF5, NOS3, Ten eleven translocation [TET1], TET3, JMJD7, AKR1C1, prenylcysteine oxidase 1 like, Methionine sulfoxide reductase A) were identified.CONCLUSIONAccording to our results, it might be considered that developing new treatment strategies based on eight hub-genes related to arginine binding, oxidoreductase activity, and methylcytosine dioxygenase activity detected at different stages of CC might increase the success of targeted therapies.
Description: Article; Early Access
URI: https://doi.org/10.5505/tjo.2023.4014
https://hdl.handle.net/20.500.14365/4877
ISSN: 1300-7467
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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