Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5357
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dc.contributor.authorBüyüktuna, S.A.-
dc.contributor.authorYerlitaş, S.İ.-
dc.contributor.authorZararsız, G.E.-
dc.contributor.authorDoğan, K.-
dc.contributor.authorKablan, D.-
dc.contributor.authorBağcı, G.-
dc.contributor.authorÖzer, S.-
dc.date.accessioned2024-06-01T08:32:41Z-
dc.date.available2024-06-01T08:32:41Z-
dc.date.issued2024-
dc.identifier.issn0146-6615-
dc.identifier.urihttps://doi.org/10.1002/jmv.29672-
dc.identifier.urihttps://hdl.handle.net/20.500.14365/5357-
dc.description.abstractThis study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus (CCHFV) infection and alterations in amino acid metabolism. Our primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease. © 2024 Wiley Periodicals LLC.en_US
dc.description.sponsorshipErciyes Üniversitesi: TSG‐2021‐10912; Erciyes Üniversitesien_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamino aciden_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectLC-MS/MSen_US
dc.subjectseverityen_US
dc.subjectalanine aminotransferaseen_US]
dc.subjectalkaline phosphataseen_US]
dc.subjectamino aciden_US]
dc.subjectamylaseen_US]
dc.subjectarginineen_US]
dc.subjectaspartate aminotransferaseen_US]
dc.subjectcreatine kinaseen_US]
dc.subjectcreatinineen_US]
dc.subjectethanolamineen_US]
dc.subjectferritinen_US]
dc.subjectgamma glutamyltransferaseen_US]
dc.subjectglutamic aciden_US]
dc.subjectglutamineen_US]
dc.subjecthistidineen_US]
dc.subjectimmunoglobulin Men_US]
dc.subjectinterleukin 6en_US]
dc.subjectlactate dehydrogenaseen_US]
dc.subjectmethionineen_US]
dc.subjectornithineen_US]
dc.subjectphenylalanineen_US]
dc.subjectribavirinen_US]
dc.subjectsteroiden_US]
dc.subjecttaurineen_US]
dc.subjecttyrosineen_US]
dc.subjectamino aciden_US]
dc.subjectbiological markeren_US]
dc.subjectactivated partial thromboplastin timeen_US]
dc.subjectadulten_US]
dc.subjectamino acid metabolismen_US]
dc.subjectarea under the curveen_US]
dc.subjectArticleen_US]
dc.subjectbiochemical analysisen_US]
dc.subjectblood clottingen_US]
dc.subjectcontrolled studyen_US]
dc.subjectCrimean Congo hemorrhagic feveren_US]
dc.subjectdiagnostic test accuracy studyen_US]
dc.subjectdisease exacerbationen_US]
dc.subjectdisease severityen_US]
dc.subjectelectrochemiluminescenceen_US]
dc.subjectelectrosprayen_US]
dc.subjectenzyme linked immunosorbent assayen_US]
dc.subjectfasting blood glucose levelen_US]
dc.subjectfemaleen_US]
dc.subjecthematocriten_US]
dc.subjecthemoglobin blood levelen_US]
dc.subjecthepatomegalyen_US]
dc.subjecthumanen_US]
dc.subjectintensive care uniten_US]
dc.subjectleukocyte counten_US]
dc.subjectliquid chromatography-mass spectrometryen_US]
dc.subjectliver dysfunctionen_US]
dc.subjectliver function testen_US]
dc.subjectlymphocyte counten_US]
dc.subjectmajor clinical studyen_US]
dc.subjectmaleen_US]
dc.subjectmetabolic reprogrammingen_US]
dc.subjectmultiple reaction monitoringen_US]
dc.subjectneutrophil counten_US]
dc.subjectplatelet counten_US]
dc.subjectreal time polymerase chain reactionen_US]
dc.subjectreceiver operating characteristicen_US]
dc.subjectscoring systemen_US]
dc.subjectseverity grading scoreen_US]
dc.subjectvirus infectionen_US]
dc.subjectageden_US]
dc.subjectliquid chromatographyen_US]
dc.subjectmetabolismen_US]
dc.subjectmiddle ageden_US]
dc.subjecttandem mass spectrometryen_US]
dc.subjectAdulten_US]
dc.subjectAgeden_US]
dc.subjectAmino Acidsen_US]
dc.subjectBiomarkersen_US]
dc.subjectChromatography, Liquiden_US]
dc.subjectDisease Progressionen_US]
dc.subjectFemaleen_US]
dc.subjectHumansen_US]
dc.subjectMaleen_US]
dc.subjectMiddle Ageden_US]
dc.subjectTandem Mass Spectrometryen_US]
dc.titleExploring free amino acid profiles in CCHF patients: Implications for disease progressionen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jmv.29672-
dc.identifier.pmid38751159en_US
dc.identifier.scopus2-s2.0-85193380919en_US
dc.departmentİzmir Ekonomi Üniversitesien_US
dc.authorscopusid36179346000-
dc.authorscopusid57464907000-
dc.authorscopusid59131041400-
dc.authorscopusid55786280900-
dc.authorscopusid58640962300-
dc.authorscopusid37036764700-
dc.authorscopusid59130908600-
dc.identifier.volume96en_US
dc.identifier.issue5en_US
dc.identifier.wosWOS:001232031300026en_US
dc.institutionauthor…-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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