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https://hdl.handle.net/20.500.14365/5362
Title: | Retrospective Evaluation of Covid-19 Incidence During Smoking Cessation Treatment With Varenicline | Authors: | Barış, Elif Ömeroğlu Şimşek, Gökçen Arıcı, Mualla Aylin Gümüştekin, Mukaddes Tosun, Metiner Kılınç, Oğuz |
Abstract: | Background: Cholinergic anti-inflammatory pathway endogenously controls inflammatory processes through activation of the α7-nicotinic acetylcholine receptor (α7nAChR). Varenicline, used in smoking cessation therapy, is a full α7nAChR agonist with anti-inflammatory effects. In this study, the frequency of coronavirus disease (COVID-19) was evaluated in patients using varenicline as a smoking cessation treatment. Methods: In this retrospective cross-sectional study, records of the 111 patients admitted to Smoking Cessation Outpatient Clinic of XXXXX University Faculty of Medicine during the COVID-19 pandemic were evaluated. The development of COVID-19 disease according to the status of the patients being positive for SARS-COV-2 was evaluated comparatively in patients who received varenicline or not. Additionally, the disease symptoms were questioned. Results: SARS-CoV-2 PCR positivity was not detected in any of 38 patients who regularly used varenicline out of 68 patients evaluated. SARS-CoV-2 PCR positivity was detected in 13 (43.3%) of 30 patients who received other treatments or irregularly used varenicline (p<0.001). Conclusions: Patients under smoking cessation treatment did not develop COVID-19 during the period of varenicline use compared to non-users suggesting that the medication may have a protective role in the development of COVID-19 which might be further investigated by clinical trials. | URI: | https://doi.org/10.34087/cbusbed.1276244 https://search.trdizin.gov.tr/yayin/detay/1230462 https://hdl.handle.net/20.500.14365/5362 |
ISSN: | 2147-9607 |
Appears in Collections: | TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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