Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5446
Title: CilioGenics: an integrated method and database for predicting novel ciliary genes
Authors: Pir, Mustafa S.
Begar, Efe
Yenisert, Ferhan
Demirci, Hasan C.
Korkmaz, Mustafa E.
Karaman, Asli
Tsiropoulou, Sofia
Keywords: Proteomic Analysis
Functional Genomics
Protein
Reveals
Motile
Components
Flagellar
Cilium
Identification
Regulators
Publisher: Oxford univ press
Abstract: Uncovering the full list of human ciliary genes holds enormous promise for the diagnosis of cilia-related human diseases, collectively known as ciliopathies. Currently, genetic diagnoses of many ciliopathies remain incomplete (). While various independent approaches theoretically have the potential to reveal the entire list of ciliary genes, approximately 30% of the genes on the ciliary gene list still stand as ciliary candidates (,). These methods, however, have mainly relied on a single strategy to uncover ciliary candidate genes, making the categorization challenging due to variations in quality and distinct capabilities demonstrated by different methodologies. Here, we develop a method called CilioGenics that combines several methodologies (single-cell RNA sequencing, protein-protein interactions (PPIs), comparative genomics, transcription factor (TF) network analysis, and text mining) to predict the ciliary capacity of each human gene. Our combined approach provides a CilioGenics score for every human gene that represents the probability that it will become a ciliary gene. Compared to methods that rely on a single method, CilioGenics performs better in its capacity to predict ciliary genes. Our top 500 gene list includes 258 new ciliary candidates, with 31 validated experimentally by us and others. Users may explore the whole list of human genes and CilioGenics scores on the CilioGenics database (https://ciliogenics.com/). Graphical Abstract
URI: https://doi.org/10.1093/nar/gkae554
https://hdl.handle.net/20.500.14365/5446
ISSN: 0305-1048
1362-4962
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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