Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5454
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dc.contributor.authorAslan, Taha-
dc.contributor.authorOzdogar, Asiye Tuba-
dc.contributor.authorSagici, Ozge-
dc.contributor.authorOzakbas, Serkan-
dc.date.accessioned2024-08-25T15:13:13Z-
dc.date.available2024-08-25T15:13:13Z-
dc.date.issued2024-
dc.identifier.issn0300-9009-
dc.identifier.issn2240-2993-
dc.identifier.urihttps://doi.org/10.1007/s13760-024-02609-7-
dc.descriptionAslan, Abdullah Taha/0000-0002-2768-5105en_US
dc.description.abstractBackground Multiple sclerosis (MS) is commonly associated with work difficulties. This study aimed to examine the relationship between work difficulties and physical disability, cognitive and social cognitive impairment, and subcortical gray matter (scGM) atrophy in pwMS. Methods Thirty-three employees with MS underwent assessments with Multiple Sclerosis Work Difficulties Questionnaire-23 MSWDQ-23. Physical disability was measured using EDSS, Timed 25-Foot Walk (T25FW), 2-Minute Walking Test (2-MWT), the Nine-Hole Peg test (N-HPT), and 12-item Multiple Sclerosis Walking Scale (MSWS-12). Cognitive functions were evaluated with Brief International Cognitive Assessment in MS (BICAMS), social cognition with Facial Emotion Identification (FEI), Reading the Mind in the Eyes Test (RMET), and Empathy Quotient (EQ). Anxiety and depression were assessed using Hospital Anxiety and Depression Scale (HADS). The association between variables was analysed using Spearman's correlation coefficient. GM volumes were calculated from 3T MRI data using Freesurfer, their potential relationship with work difficulties were evaluated through a linear regression model. Results MSWDQ-23 was strongly correlated with T25FW and MSWS-12 (p<0.01), moderately correlated with EDSS, 2MWT, HAD, BICAMS, and EQ (p<0.05). According to the linear regression model the decrease in volumes of total GM and scGM, bilateral Thalamus, bilateral Hippocampus, left Putamen, and right Caudate related with the severity of work difficulties (R-2=0.815, p=0.25). Conclusion This study provides valuable insights into the multifaceted nature of work difficulties experienced by pwMS. It suggests that not only physical disability but also other factors, such as mood, cognition, empathy, and cortical and subcortical gray matter atrophy may contribute to work difficulties among pwMS.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK); TUBITAK [220S940]en_US
dc.description.sponsorshipA scholarship was received from Scientific and Technological Research Council of Turkey (TUBITAK) for MRI Scans. TUBITAK Project number: 220S940.en_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectWork Difficultiesen_US
dc.subjectPhysical Disabilityen_US
dc.subjectCognitionen_US
dc.subjectSocial Cognitionen_US
dc.subjectGray Matter Atrophyen_US
dc.titleThe Relationship Between Work Difficulties and Physical Disability, Cognitive and Social Cognitive Impairment and Subcortical Gray Matter Atrophy in Persons With Multiple Sclerosisen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s13760-024-02609-7-
dc.identifier.pmid39044119-
dc.identifier.scopus2-s2.0-85199275825-
dc.departmentİzmir Ekonomi Üniversitesien_US
dc.authoridAslan, Abdullah Taha/0000-0002-2768-5105-
dc.identifier.volume124en_US
dc.identifier.issue6en_US
dc.identifier.startpage1891en_US
dc.identifier.endpage1898en_US
dc.identifier.wosWOS:001275225400001-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
dc.identifier.wosqualityQ3-
dc.description.woscitationindexScience Citation Index Expanded-
item.openairetypeArticle-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
crisitem.author.dept09.02. Internal Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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