A comprehensive systematic review of fMRI studies on brain connectivity in healthy children and adolescents: Current insights and future directions

Abstract

This systematic review considered evidence of children's and adolescents' typical brain connectivity development studied through resting-state functional magnetic resonance imaging (rs-fMRI). With aim of understanding the state of the art, what has been researched thus far and what remains unknown, this paper reviews 58 studies from 2013 to 2023. Considering the results, rs-fMRI stands out as an appropriate technique for studying language and attention within cognitive domains, and personality traits such as impulsivity and empathy. The most used analyses encompass seed-based, independent component analysis (ICA), the amplitude of the low frequency fluctuations (ALFF), and fractional ALFF (fALFF). The findings highlight key themes, including age-related changes in intrinsic connectivity, sex-specific patterns, and the relevance of the Default Mode Network (DMN). Overall, there is a need for longitudinal approaches to trace the typical developmental trajectory of neural networks from childhood through adolescence with fMRI at rest.