Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5568
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dc.contributor.authorKocabaş, Umut-
dc.contributor.authorErgin, Işıl-
dc.contributor.authorYavuz, Veysel-
dc.contributor.authorAltın, Cihan-
dc.contributor.authorKaplan, Mehmet-
dc.contributor.authorOztekin, Guelsuem Meral Yilmaz-
dc.contributor.authorDogdus, Mustafa-
dc.date.accessioned2024-10-25T15:17:53Z-
dc.date.available2024-10-25T15:17:53Z-
dc.date.issued2024-
dc.identifier.issn2055-5822-
dc.identifier.urihttps://doi.org/10.1002/ehf2.15049-
dc.identifier.urihttps://hdl.handle.net/20.500.14365/5568-
dc.description.abstractAims: We aimed to determine the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and to identify clinical factors associated with their use in patients with heart failure (HF) in a real-life setting. Methods: Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study is a multicentre, cross-sectional and observational study that included HF patients in the outpatient setting regardless of ejection fraction from 19 cardiology centres between August 2023 and December 2023. Results: The study population consisted of 1923 patients with HF, predominantly men (61.2%), with a median age of 66 (range: 19-101) years. Overall, 925 patients (48.1%) were receiving SGLT2is. Among the study population, 22.1% had HF with preserved ejection fraction, 21.5% had HF with mildly reduced ejection fraction, 56.4% had HF with reduced ejection fraction and the use of SGLT2is was 42.0%, 47.9% and 50.6% in each group, respectively (P = 0.012). The use of SGLT2is was 76.6% in patients with HF and diabetes, 19.8% in patients with HF and chronic kidney disease and 26.8% in patients without diabetes and chronic kidney disease (P < 0.001). Higher education level [odds ratio (OR): 1.80; 95% confidence interval (CI): 1.06-3.05; P = 0.027], higher household income (OR: 3.46; 95% CI: 1.27-9.42; P = 0.015), New York Heart Association functional class IV (OR: 2.72; 95% CI: 1.16-6.35; P = 0.021), diabetes (OR: 9.42; 95% CI: 6.72-13.20; P < 0.001), the use of angiotensin receptor-neprilysin inhibitors (ARNis) (OR: 4.09; 95% CI: 2.39-7.01; P < 0.001), the use of mineralocorticoid receptor antagonists (MRAs) (OR: 2.02; 95% CI: 1.49-2.75; P < 0.001), the use of loop diuretics (OR: 1.62; 95% CI: 1.18-2.22; P = 0.003) and the use of thiazide diuretics (OR: 1.72; 95% CI: 1.30-2.29; P < 0.001) were independently associated with the use of SGLT2is. Conversely, atrial fibrillation (OR: 0.63; 95% CI: 0.45-0.88; P = 0.008), chronic kidney disease (OR: 0.53; 95% CI: 0.37-0.76; P = 0.001), the use of dihydropyridine calcium channel blockers (OR: 0.68; 95% CI: 0.48-0.98; P = 0.042) and the use of statins (OR: 0.67; 95% CI: 0.49-0.91; P = 0.010) were independently associated with the non-use of SGLT2is. Conclusions: The RED-HEART study provided comprehensive real-world data about implementing SGLT2is in patients with HF. These results suggest that there is a need for organized action and close collaboration between healthcare providers to improve the implementation of SGLT2is, especially in patients with HF with preserved ejection fraction and chronic kidney disease.en_US
dc.description.sponsorshipWe would like to thank Prof. Dr. Seckin Pehlivanolu for his critical review of this study.en_US
dc.language.isoenen_US
dc.publisherWiley Periodicals, Incen_US
dc.relation.ispartofEsc heart failureen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectguidelineen_US
dc.subjectheart failureen_US
dc.subjectsodium-glucose cotransporter 2 inhibitorsen_US
dc.subjectEsc Guidelinesen_US
dc.subjectOutcomesen_US
dc.titleReal-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART studyen_US
dc.typeArticleen_US
dc.typeArticle; Early Accessen_US
dc.identifier.doi10.1002/ehf2.15049-
dc.identifier.pmid39340234en_US
dc.identifier.scopus2-s2.0-85205077364en_US
dc.departmentİzmir Ekonomi Üniversitesien_US
dc.authoridCakan, Fahri/0000-0002-5427-3480-
dc.authorscopusid57211015002-
dc.authorscopusid25951372300-
dc.authorscopusid55457354700-
dc.authorscopusid23979295100-
dc.authorscopusid56824971000-
dc.authorscopusid57207828905-
dc.authorscopusid57204894031-
dc.identifier.wosWOS:001321727100001en_US
dc.institutionauthor-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.grantfulltextnone-
item.openairetypeArticle-
item.openairetypeArticle; Early Access-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
crisitem.author.dept09.02. Internal Sciences-
crisitem.author.dept09.02. Internal Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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