Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5572
Title: Assessment of neutrophil/lymphocyte ratio and mean platelet volume values in patients with diabetes mellitus diagnosis: A case-control study
Authors: Aygün, K.
Asma, Sakalli, A.
Küçükerdem, H.S.
Aygün, O.
Gökdemir, Ö.
Keywords: erythrocyte indices
glycated hemoglobin
glycemic control
mean platelet volume
neutrophils
Adult
Aged
Case-Control Studies
Diabetes Mellitus, Type 2
Erythrocyte Indices
Female
Glycated Hemoglobin
Humans
Leukocyte Count
Lymphocyte Count
Lymphocytes
Male
Mean Platelet Volume
Middle Aged
Neutrophils
Retrospective Studies
C reactive protein
hemoglobin A1c
glycated hemoglobin
adult
age
aged
Article
case control study
cell size
controlled study
diabetes mellitus
diabetic patient
erythrocyte
female
glycemic control
hematocrit
human
human cell
leukocyte count
major clinical study
male
mean corpuscular volume
mean platelet volume
neutrophil lymphocyte ratio
non insulin dependent diabetes mellitus
retrospective study
blood
diagnosis
lymphocyte
lymphocyte count
middle aged
neutrophil
non insulin dependent diabetes mellitus
Publisher: Lippincott Williams and Wilkins
Abstract: Diabetes mellitus, fundamentally characterized by hyperglycemia, leads to significant metabolic disturbances. Type 2 diabetes mellitus is a chronic, inflammatory, preventable metabolic disease that is a significant health issue globally. The neutrophil-to-lymphocyte ratio (NLR) is an essential marker of systemic inflammation. We aimed to reveal the relationship between long-term glucose control and NLR, mean platelet volume (MPV), and red blood cell width in patients with type 2 diabetes. This was a retrospective case-control study. A total of 3532 applications in 2 years time were identified. Age, gender, medical history, white blood cell (WBC), hemoglobin, mean corpuscular volume (MCV), MPV, red blood cell width, NLR, hematocrit, platelet, C-reactive protein, Haemoglobin A1C data of the patients were analyzed. 1790 patients were included. A significant positive correlation was found between HbA1c and age, white blood cell, hematocrit, MCV, red blood cell width, NLR, and CRP. A statistically significant negative correlation was found between HbA1c and MCV. The results showed statistically significant differences between NLR, MPV, WBC, MCV, age, and HbA1c levels. Increased HbA1c levels are usually associated with an increase in these parameters. This is important for determining the risk of complications and protecting target organs in diabetic patients. A significant decrease in MCV levels was found as HbA1c levels increased. This suggests that evaluating red blood cells in routine controls of diabetic patients may indicate glycemic control. These findings may be valuable in early diagnosis of complications. Copyright © 2024 the Author(s).
URI: https://doi.org/10.1097/MD.0000000000039661
https://hdl.handle.net/20.500.14365/5572
ISSN: 0025-7974
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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