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https://hdl.handle.net/20.500.14365/6182
Title: | Characterizing the Heterogeneity of Neurodegenerative Diseases Through Eeg Normative Modeling | Authors: | Tabbal, Judie Ebadi, Aida Mheich, Ahmad Kabbara, Aya Guntekin, Bahar Yener, Gorsev Hassan, Mahmoud |
Publisher: | Nature Portfolio | Abstract: | Neurodegenerative diseases like Parkinson's (PD) and Alzheimer's (AD) exhibit considerable heterogeneity of functional brain features within patients, complicating diagnosis and treatment. Here, we use electroencephalography (EEG) and normative modeling to investigate neurophysiological mechanisms underpinning this heterogeneity. Resting-state EEG data from 14 clinical units included healthy adults (n = 499) and patients with PD (n = 237) and AD (n = 197), aged over 40. Spectral and source connectivity analyses provided features for normative modeling, revealing significant, frequency-dependent EEG deviations with high heterogeneity in PD and AD. Around 30% of patients exhibited spectral deviations, while similar to 80% showed functional source connectivity deviations. Notably, the spatial overlap of deviant features did not exceed 60% for spectral and 25% for connectivity analysis. Furthermore, patient-specific deviations correlated with clinical measures, with greater deviations linked to worse UPDRS for PD (rho = 0.24, p = 0.025) and MMSE for AD (rho = -0.26, p = 0.01). These results suggest that EEG deviations could enrich individualized clinical assessment in Precision Neurology. | URI: | https://doi.org/10.1038/s41531-025-00957-6 https://hdl.handle.net/20.500.14365/6182 |
ISSN: | 2373-8057 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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