Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/6280
Title: Determination of Survival Associated Genetic Biomarkers To Discover Novel Therapeutic Targets for Acute Myeloid Leukaemia
Authors: Ergun, Cansu
Kiraz, Yagmur
Ayna Duran, Gizem
Keywords: Acute Myeloid Leukemia
DNA Microarrays
Gene Expression Profiling
Survival Analysis
Drug Repurposing
Publisher: Taylor & Francis Ltd
Abstract: Acute myeloid leukemia (AML) is a heterogeneous malignancy specified by clonal proliferation of hematopoietic stem cells. This study identifies novel therapeutics for AML by integrating differential gene expression (DEG) and survival analyses. Publicly available GEO microarray datasets were analyzed, including data from 615 AML patients and 22 healthy controls. Multivariate Cox regression identified hazardous genes impacting survival. Protein-protein interaction networks using CytoScape revealed hub genes such as CCT5, ZBTB16, APP, and PTPN6. Functional enrichment revealed key AML-related pathways, such as PI3K/Akt and NF-kappaB signaling. Drug repurposing using the LINCS L1000CDS2 database highlighted potential therapeutics, including 16-Hydroxytriptolide and Tryptosthin AG-1478, with roles in reversing hazardous gene expression patterns. Additional candidates such as Vemurafenib, Parthenolide and Wortmannin, demonstrated promise as targeted agents. These findings underscore the potential of integrating bioinformatics and drug discovery to identify precision medicine in AML. Further studies are warranted to validate these targets and explore their clinical utility.
URI: https://doi.org/10.1080/1120009X.2025.2527464
https://hdl.handle.net/20.500.14365/6280
ISSN: 1120-009X
1973-9478
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

Page view(s)

4
checked on Jul 28, 2025

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.