PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

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Citation - WoS: 5
Citation - Scopus: 6
Adaptation of Quality of Life Measure for Limb Lymphedema-Arm in Turkish Women With Breast Cancer-Related Lymphedema
(Lippincott Williams & Wilkins, 2021) Karayurt, Ozgul; Deveci, Zeynep; Eyigor, Sibel; Inbat, Menekse Ozgur
Background Quality-of-life measures are needed for clinicians and researchers to identify quality of women's life with breast cancer-related lymphedema (BCRL). Objective To adapt Quality of Life Measure for Limb Lymphedema-Arm into Turkish (TR) and to test its validity and reliability. Methods This is a methodological and cross-sectional study and was conducted in the lymphedema outpatient clinic of a university hospital. The study included 109 women with BCRL. After linguistic validity of the scale was achieved, confirmatory factor analyses and known group validity were used to test its construct validity. Reliability of the scale was tested with Cronbach's alpha, item-total correlations, and Spearman-Brown coefficient. Results After linguistic validity was achieved, opinions requested from 5 experts specializing in lymphedema showed that item and content validity indexes of the scale were 1. Fit indexes of confirmatory factor analysis were as follows: chi(2)/df = 1.86, root mean square error of approximation = 0.089, standardized root mean square residual = 0.09, and comparative fit index = 0.81. Known group validity analysis showed a significant difference in the mean scores for the subscales of Quality of Life Measure for Limb Lymphedema-Arm-TR, symptom, function, and body image/appearance in terms of lymphedema stages (P < .05). The internal reliability coefficients for the subscales ranged from 0.78 and 0.86. The item-total correlation coefficients ranged between 0.36 and 0.73. Conclusion Quality of Life Measure for Limb Lymphedema-Arm-TR was found to be valid and reliable in the TR population. It could be used in research to evaluate the quality of life in patients with BCRL. Implications for Practice The scale can be used to evaluate effectiveness of nursing interventions directed toward patients developing breast cancer-related lymphedema in clinical settings and studies.
Citation - WoS: 7
Citation - Scopus: 9
Adults' Visual Cue Preferences and Wayfinding Abilities in Healthcare Centers
(Sage Publications Inc, 2023) Asli, Afsaneh Alizadeh; Moshfeghifar, Samaneh; Mousighichi, Pouya; Samimi, Paniz Mousavi
Objectives: Physical and visual elements that help people find their way around an environment are called visual cues (VCs). The current study aims to evaluate adults' wayfinding abilities (navigation, orientation, spatial anxiety, and distance estimation) and VC (navigational color coding) preferences in terms of color and position; additionally, investigates their differences in adults' life span phases (young adults, early middle-aged adults, and late middle-aged adults). Background: Wayfinding in complex environments such as healthcare centers has been challenging for most people. Although VCs are being used increasingly to facilitate wayfinding, considering people's preferences regarding VCs, especially navigational color coding, are neglected. Methods: Obtained data from a survey of 375 healthcare center visitors with textual and photo questionnaires were analyzed by descriptive statics and one-way analysis of variance. Results: Young adults preferred VCs with mixed colors and positioned in the middle of the floor, early middle-aged adults preferred warm color VCs in the middle of the wall, and late middle-aged adults preferred warm color VCs at the bottom of the wall. Additionally, the results demonstrated that with aging, navigation and distance estimation abilities deteriorate, and spatial anxiety increases. Conclusions: The outcomes of the present study increase our knowledge regarding the impact of adults' life span phases on their wayfinding abilities and VC preferences and offer suggestions for architects and healthcare center stakeholders to provide environments that improve adults' wayfinding.
Citation - WoS: 4
Citation - Scopus: 5
Advanced Nurse-Patient Communication System
(Springer, 2012) Unluturk, Mehmet S.
Effective communication is the most important part of any healthcare organization. For many years, hospital nurse call solutions had been stand-alone systems with occasional integration to pocket paging for outputting patient call alerts to mobile staff. In the late 1990's, technology enabled in-building wireless phones to supplement or replace paging systems as a means of not only sending alerts, but also enabling voice communication between mobile staff and patients. Today's nurse call market requires integration of additional information from location and ADT (admit, discharge, transfer) systems into what have traditionally been nurse call applications. This system information is required not only at the nursing station, pagers, and phones, but also at PC's placed on each patient care floor in hallways, nurse stations, and offices, and at areas away from the patients, including administrator and clinical engineering offices. It is crucial that nurses have the latest patient information in their hand wherever they go in the hospital. In this paper, MatchMaker.NET has been developed to integrate all these technologies into the hospital's LAN to improve nurse-patient communication.
Citation - WoS: 10
Citation - Scopus: 9
Advancements in Platinum Chemotherapy for Metastatic Castration-Resistant Prostate Cancer: Insights and Perspectives
(ELSEVIER SCI LTD, 2024) Akkuş, Erman; Arslan, Çağatay; Ürün, Yüksel
Despite improvements in survival, metastatic castration-resistant prostate cancer (mCRPC) remains a significant clinical challenge. While taxanes, new hormonal agents, radiopharmaceuticals, and PARP inhibitors offer valuable treatment options, this review explores the potential of platinum chemotherapies (carboplatin, cisplatin, and oxaliplatin) as alternative choices. Existing research demonstrates promising preliminary results for platinum-based therapies in mCRPC showing PSA response rates (7.7-95 %) and improved overall survival (8-26.6 months). However, chemotherapy-related cytopenias are a frequent side effect. Further research is underway to evaluate the efficacy of platinum regimens against specific mCRPC histopathological variants, particularly aggressive subtypes where the carboplatin and cabazitaxel combination is already recommended. The unique DNA-targeting action of platinum therapy holds promise for patients with deficient DNA repair (dDDR), especially those with BRCA mutations. This potential is supported by both preclinical and ongoing clinical research. Given the limited success of immunotherapy in mCRPC, researchers are exploring the potential for platinum therapies to enhance its efficacy. Additionally, trials are investigating the synergy of combining platinum therapy with both immunotherapy and PARP inhibitors. Further exploration into the effectiveness of platinum therapies in specific mCRPC subpopulations, particularly those with dDDR, is crucial for optimizing their future use. In conclusion, this review highlights the promising potential of platinum-based chemotherapy as a valuable treatment option for mCRPC. While current evidence is encouraging, ongoing research is essential to further optimize its efficacy, identify optimal combinations with other therapies, and better understand its impact on specific mCRPC subpopulations.
Citation - WoS: 2
Citation - Scopus: 2
Aging Attenuated Theta Response During Multistable Perception
(Wiley, 2023) Küçük, Kurtulus Mert; Mathes, Birgit; Schmiedt-Fehr, Christina; Başar Eroğlu, Canan
Multistable stimuli are physically unchanging, but elicit spontaneous perceptual reversals between multiple internally generated perceptual alternatives. Perceptual reversal rates seem to decrease in older adults; however, there is no literature on the electrophysiological correlates of this performance decrease. Here, we aimed to identify age-related changes in theta activity that relate to decreased reversal rates of older adults. Electroencephalography (EEG) of young (n = 15) and older adults (n = 15) was recorded during presentation of stroboscopic alternative motion (SAM) and a control stimulus. Time-frequency amplitudes were extracted in 4-8 Hz via Morlet wavelet convolution. Older adults had lower SAM reversals as well as decreased accuracy, increased reaction time (RT) and increased RT variability in the control task. In older adults, reversal-related frontal theta response was diminished, yet parietal theta was intact. In the parietal area, the relationship between theta response and reversal rates was robust, but in the frontal area, was dependent on age-related variance. Result indicated that, in older adults, top-down facilitation of perceptual reversals was impaired. This appears to result in a predominantly bottom-up resolution of perceptual multistability. Age-related degradation of sensory areas in this bottom-up-driven resolution process might have slowed reversals. This study presents the first electrophysiological correlates of age-related impairment in multistable perceptual integration.
Citation - WoS: 36
Citation - Scopus: 39
Alteration of Mirnas in Small Neuron-Derived Extracellular Vesicles of Alzheimer's Disease Patients and the Effect of Extracellular Vesicles on Microglial Immune Responses
(Springernature, 2022) Durur, Devrim Yagmur; Tastan, Bora; Tufekci, Kemal Ugur; Olcum, Melis; Uzuner, Hamdiye; Karakulah, Gokhan; Yener, Görsev
Alzheimer's disease (AD) is one of the most severe neurodegenerative diseases observed in the elderly population. Although the hallmarks of AD have been identified, the methods for its definitive diagnosis and treatment are still lacking. Extracellular vesicles (EVs) have become a promising source for biomarkers since the identification of their content. EVs are released from multiple cell types and, when released from neurons, they pass from the brain to the blood with their cargo molecules. Hence, neuron-specific EV-resident microRNAs (miRNAs) are promising biomarkers for diagnosis of AD. This study aimed to identify altered miRNA content in small neuron-derived extracellular vesicles (sNDEVs) isolated from AD patients and healthy individuals. Furthermore, we examined the role of sNDEV-resident miRNAs in neuron-glia cellular interaction to understand their role in AD propagation. We identified 10 differentially expressed miRNAs in the sNDEVs of patients via next-generation sequencing and validated the most dysregulated miRNA, let-7e, with qRT-PCR. Let-7e was significantly increased in the sNDEVs of AD patients compared with those of healthy controls in a larger cohort. First, we evaluated the diagnostic utility of let-7e via ROC curve analysis, which revealed an AUC value of 0.9214. We found that IL-6 gene expression was increased in human microglia after treatment with sNDEVs of AD patients with a high amount of let-7e. Our study suggests that sNDEV-resident let-7e is a potential biomarker for AD diagnosis, and that AD patient-derived sNDEVs induce a neuroinflammatory response in microglia.
Citation - WoS: 25
Citation - Scopus: 29
Alterations in Levels of 8-Oxo '-deoxyguanosine and 8-Oxoguanine Dna Glycosylase 1 During a Current Episode and After Remission in Unipolar and Bipolar Depression
(Pergamon-Elsevier Science Ltd, 2020) Ceylan, Deniz; Yilmaz, Selda; Tuna, Gamze; Kant, Melis; Er, Ayse; Ildiz, Aysegul; Verim, Burcu
Introduction: Previous studies showed significant increases in DNA base damage markers and significant alterations in base excision repair enzymes in patients with unipolar and bipolar depression. We aimed to investigate changes in urine 8-Oxo-2'-deoxyguanosine (8-oxo-dG) and gene expression levels of 8-Oxoguanine DNA glycosylase 1 (OGG1) during a current depressive episode and after remission in bipolar and unipolar disorders. Methods: Twenty-four acutely depressed bipolar (BD), 33 unipolar depression (UD) patients and 61 healthy controls were included in the study. Clinical evaluations, blood and urine sampling were completed at baseline and at remission after eight weeks. The urine 8-oxo-dG levels were assessed by liquid chromatography tandem mass spectrometry and adjusted for urine creatinine levels. The gene expression levels of OGG1 were determined from cDNA extracted from blood samples, using real time-polymerase chain reaction. Results: At baseline, patients presented significantly higher levels of 8-oxo-dG (p = 0.008), and lower gene expression of OGG1 (p = 0.024) compared to controls. Levels of either 8-oxo-dG or OGG1 expression did not differ between BD and UD. In patients who remitted by the 8th week (n = 30), 8-oxo-dG decreased significantly (p = 0.001), and gene expression levels of OGG1 increased by 2.95 times compared to baseline levels (p = 0.001). All comparisons were adjusted for age, sex, smoking status and body mass index. Conclusion: Our results suggest that patients with bipolar and unipolar mood disorders present increased 8-oxo-dG and decreased gene expression levels of OGG1 in current depressive episodes, and that these changes might be reversed by the resolution of depressive symptoms. The causal relationship between DNA damage and repair requires further exploration.
Citation - WoS: 18
Citation - Scopus: 18
Altered Gamma and Theta Oscillations During Multistable Perception in Schizophrenia
(Elsevier, 2020) Rurup, Linda; Mathes, Birgit; Schmiedt-Fehr, Christina; Wienke, Annika Susann; Ozerdem, Aysegul; Brand, Andreas; Başar Eroğlu, Canan
Objective: Coherent object perception in patients with schizophrenia is known to be impaired. Oscillatory brain dynamics constitute a fundamental mechanism for the coordinated communication of neural circuits. Such dynamics have been proposed to reflect impaired spatio-temporal integration of sensory and cognitive processes during object perception in schizophrenia. Method: EEG recordings of patients with schizophrenia (n = 23) and control participants (n = 23) were examined. Presented were either an ambiguous (multistable) stimulus, endogenously inducing switching between two perceptual alternatives, or a slightly modified unambiguous control stimulus, during which perceptual reversals were triggered by a minor change in the stimulus configuration. Event-related amplitude modulation induced by perceptual reversals was analyzed for theta (3-8 Hz) and gamma band oscillations (28-48 Hz). Results: Patients displayed increased reaction times and more errors when indicating unambiguous reversals. The patients ' amplitude enhancement of theta oscillations was diminished in both task conditions. During the control task were gamma amplitudes larger in patients than in healthy participants. Conclusion: The results indicate that impairments in generating coherent percepts are reflected in alterations of multiple frequency bands and time windows. Changes in gamma band oscillations may reflect the patients' impairments in perceptuo-cognitive integration processes. Diminished theta amplitude modulation in patients further emphasize diminished top-down cognitive control during perceptual reversals. Significance: This study provides insight into how theta and gamma oscillations underlie changes in object perception, and thereby possibly the generation of core symptoms, in schizophrenia. This paper is dedicated to Prof. Dr. Erol Basar, a pioneer in research on oscillatory braindynamics. He was tireless in his effort to understand brain functions and integratedphilosophy, physics, biology and psychology in his research. His vision on how informationis coded in brain networks inspired many researchers in the last 40 years. With him, we not only lose an exceptional researcher, but also a supportive academic teacher and mentor with a persistent, prolific enthusiasm for international and collaborative projects.
Citation - WoS: 112
Citation - Scopus: 130
Analysis of High-Dimensional Phase Space Via Poincare Section for Patient-Specific Seizure Detection
(IEEE-Inst Electrical Electronics Engineers Inc, 2016) Zabihi, Morteza; Kiranyaz, Serkan; Rad, Ali Bahrami; Katsaggelos, Aggelos K.; Gabbouj, Moncef; İnce, Türker
In this paper, the performance of the phase space representation in interpreting the underlying dynamics of epileptic seizures is investigated and a novel patient-specific seizure detection approach is proposed based on the dynamics of EEG signals. To accomplish this, the trajectories of seizure and nonseizure segments are reconstructed in a high dimensional space using time-delay embedding method. Afterwards, Principal Component Analysis (PCA) was used in order to reduce the dimension of the reconstructed phase spaces. The geometry of the trajectories in the lower dimensions is then characterized using Poincare section and seven features were extracted from the obtained intersection sequence. Once the features are formed, they are fed into a two-layer classification scheme, comprising the Linear Discriminant Analysis (LDA) and Naive Bayesian classifiers. The performance of the proposed method is then evaluated over the CHB-MIT benchmark database and the proposed approach achieved 88.27% sensitivity and 93.21% specificity on average with 25% training data. Finally, we perform comparative performance evaluations against the state-of-the-art methods in this domain which demonstrate the superiority of the proposed method.
An Analysis of Sample Size Calculations in Randomized Control Trials in Emergency Medicine
(W B Saunders Co-Elsevier Inc, 2025) Limon, Onder; Dogan, Nurettin Ozgur; Limon, Gulsum; Aksay, Ersin
Introduction: Sample size calculation enhances the quality of randomized clinical trials (RCTs) and, according to the CONSORT statement, should be reported and justified in published articles. This study aimed to evaluate the current quality of sample size calculation reporting in RCTs published in emergency medicine journals. Methods: The Web of Science (WoS) database was used for article retrieval. Journals indexed in WoS, published in English, categorized under "emergency medicine," and ranked in Q1 were included in the search. The sample size calculation method, power value, alpha value, effect size, and consideration of missing data were evaluated. Results: A total of 252 RCTs from 12 emergency medicine journals were included in the study. Only 30% of the articles explicitly stated compliance with CONSORT guidelines. Sample size calculations were reported in 84% of the articles. Alpha values were omitted in 12 % and beta (power) values in 8% of the articles. Effect sizes were not reported in 90 % of the studies. Notably, 11 % of the articles claiming CONSORT compliance did not include a sample size analysis. In the logistic regression analysis, none of the variables showed a statistically significant association with the presence of sample size analysis. Conclusion: Although emergency medicine journals show relatively better adherence to sample size calculation reporting compared to some other disciplines, their overall performance remains suboptimal. The findings highlight ongoing and significant deficiencies in the quality of RCT reporting, indicating that even leading journals in the field fall short of fully meeting recommended standards. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Citation - WoS: 2
Citation - Scopus: 2
Analysis of the Quadratus Lumborum Muscle Activity on Leg Length Discrepancy: a Randomized Controlled Trial
(Ios Press, 2022) Eryigit, Sevim; Al Kafee, Abdullah; Akan, Aydin
BACKGROUND: Quadratus lumborum (QL) discrete region extensions might change depending on whether leg length discrepancy (LLD) individually has any extra erector spinae action in the lumbar spine, which can result in serious injury to the lower extremities and lumbar vertebrae. OBJECTIVE: This study aims to investigate the effect of QL muscle activity on LLD by using electromyography (EMG) signals. METHODS: The study employed a randomized controlled design. A total of 100 right-handed volunteers were included in this study. All participants were assessed manually by tape measurement for LLD. EMG signals were recorded during the resting and maximal isometric contraction positions to determine QL muscle activity. The power spectral density (PSD) methods were applied to compute EMG signals. RESULTS: In maximal isometric contraction position, comparing the short right LLD (Right side = 0.00064 +/- 0.00001, Left side = 0.00033 +/- 0.0006) and short left LLD (Right side = 0.00001 +/- 0.00008, Left side = 0.00017 +/- 0.0001), it was found that the short right LLD group had significantly increased PSD of EMG values. In resting position, the short right LLD (Right side = 0.0002 +/- 0.0073, Left side = -0.00016 +/- 0.0065) had significantly increased PSD of EMG compared to the short left LLD (Right side = 0.00004 +/- 0.0003, Left side = 0.0001 +/- 0.0008) values of the QL muscle activity. The results of both groups were also statistically significant (p < 0.05). CONCLUSIONS: The present study showed that it is possible to determine effective experimental interventions for functional LLD using EMG signal analysis of QL muscle activity on an asymptomatic normal population.
Citation - WoS: 2
Citation - Scopus: 1
Anthropometric and Demographic Properties Affect Balance in Healthy Adults: an Observational Study
(Edizioni Minerva Medica, 2021) Kurt, Merve; Tatlici, Ezgi; Simsek, Tulay Tarsuslu
BACKGROUND: Anthropometric and demographic properties may affect balance, but there is no consensus on this subject; so, there is a need for studies that explore it. This study aimed to assess the relationship between balance and anthropometric as well as demographic properties; and to determine the effect of anthropometric and demographic properties on balance in healthy adults. METHODS: Sixty healthy adults were included in this study. The ages of the participants were questioned; height, body weight, Body Mass Index, head circumference, upper extremity, lower extremity, and foot length were evaluated. and shoe numbers were recorded. Balance assessments were performed with the Balance Master System device. RESULTS: The mean age of the participants was 23.50 +/- 1.97 years. The balance developed with age (P<0.05), while there was a negative correlation between height and balance (P<0.05). Weight gain affected balance negatively (P<0.05). The increase in head circumference, extremity, and foot length was associated with a deterioration in balance (P<0.05). CONCLUSIONS: The results of the current study were showed that anthropometric and demographic properties affect balance. The increase in some of the anthropometric and demographic properties including height. weight. head circumference, extremity, and foot length harms the balance. During balance assessments, anthropometric and demographic characteristics should be considered as a factor that affects balance.
Citation - WoS: 11
Citation - Scopus: 13
Antibody separation using lectin modified poly(HEMA-EDMA) hydrogel membranes
(Taylor & Francis Ltd, 2018) Demir, Esra Feyzioglu; Kuru, Cansu Ilke; Uygun, Murat; Uygun, Deniz Aktas; Akgol, Sinan
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10.85 mol/g and 3.52 mg/g, respectively. Optimum conditions for IgG adsorption such as adsorption capacity, pH and reusability profile of HMs were judiciously characterized. Maximum IgG adsorption capacity of hydrogel membrane was found to be as 26.81 mg/g. Adsorbed IgG was eluted successfully by using 2.0 M of NaCl solution. Reusability profiles of hydrogel membrane in five adsorption-desorption cycles revealed that there was no significant decrease in IgG adsorption capacity at the end of the 5th reuse. The hydrogel membranes reported here hold considerable promise as an effective sorbent system for IgG adsorption with good stability and efficient repeated usage.
Citation - WoS: 2
Citation - Scopus: 4
Anxiety, Depression, Stress, and Self-Esteem in Turkish Parents of Children With Microtia
(Sage Publications Inc, 2023) Turhan Damar, Hale; Öğce, Filiz
Objective To describe factors affecting anxiety, depression, stress, and self-esteem in parents of children with microtia. Design Cross-sectional correlational study. Participants Parents (N = 117) of children with microtia were recruited nationally through a Turkish craniofacial non-governmental organization's social media. Main Outcome Measures Demographics, parental report of microtia experiences and concerns, the Depression Anxiety Stress Scale, and the Rosenberg Self-Esteem Scale. Results The mean parental age was 35.61 & PLUSMN; 5.96 years and 74.4% were female. The mean age of their children was 6.08 & PLUSMN; 4.22 years, 69.2% were male, 93.8% had unilateral microtia, and 14.5% had ear reconstruction. Some parents had low self-esteem (24.8%) and were in the severe range for depression (30.7%), anxiety (25.6%), and stress (21.4%). Depression (M = 7.43, SD = 5.35) was associated with worry about child's future (& beta; = 0.25, P = .013), microtia information given around birth (& beta; = -0.20, P = .024), and child no ear surgery (& beta; = -0.23, P = .008), while stress (M = 8.21, SD = 5.37) was associated with worry about the child's future (& beta; = 0.28, P = .008). Parental self-esteem (M = 29.59, SD = 5.10) was related to child having ear surgery (& beta; = 0.19, P = .047) and information about microtia provided around birth (& beta; = 0.22, P = .018). There were no significant associations with Anxiety (M = 6.04, SD = 4.82) identified by multiple regression. Conclusions While most parents were in the average to moderate range for clinical concerns, a fifth to a third of participants were in the severe range for depression, anxiety, and stress and a quarter of participants for low self-esteem. Informing families about the microtia treatment process, having the child have surgery, and interventions for reducing their future concerns may provide psychological relief for them.
Aso Visual Abstract: Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the Neosentiturk-Trials Mf18-02/18-03
(Springer, 2025) Cabioglu, N.; Karanlik, H.; Igci, A.; Muslumanoglu, M.; Gulcelik, M.A.; Uras, C.; Ozmen, V.
Assessing Sleep Disorders in Neuromyelitis Optica Spectrum Disorder: A Comparison of Qualitative and Quantitative Approaches
(Elsevier Sci Ltd, 2025) Ture, Sabiha; Beckmann, Yesim; Ozlem, Enise Nur; Uzunkopru, Cihat; Ozakbas, Serkan
Objectives: This study aimed to: 1) evaluate the macrostructure of sleep and identify the presence of sleep disorders such as hypersomnia, fatigue, apnea risk, and restless legs syndrome (RLS) in neuromyelitis optica spectrum disorder (NMOSD) patients, using both questionnaires and quantitative tests; 2) assess the correlation between the data from these questionnaires and quantitative tests in NMOSD patients, and predict which patients may require further investigation. Methods: The study population comprised 26 consecutive NMOSD patients, along with a control group of 20 healthy volunteers. Polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT) were conducted, along with the administration of various questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepinesss Scale (ESS), STOP-Bang scale, RLS diagnostic questionnaire, RLS Severity Scale, and the Beck Depression Inventory (BDI). These assessments were performed prospectively to evaluate sleep quality, daytime sleepiness, the detection of obstructive sleep apnea syndrome (OSAS), the presence of RLS, the severity of RLS, and the presence of depressive symptoms. Results: An increase in the NREM1 ratio was observed in NMOSD patients compared to healthy controls, with higher values for total apnea hypopnea index (AHI), REM AHI, and NREM AHI, while the minimum O2 saturation was lower. However, no significant differences were observed between the groups regarding sleep efficiency, periodic legs movement (PLM) index, arousal index, sleep latency, and REM latency. According to the MSLT data analysis, we found that sleep latency was shorter, and hypersomnia/narcolepsy occurred more frequently. There was no significant difference in the STOP-Bang score between the two groups. The ESS score, PSQI score, presence of RLS, and body mass index (BDI) score were significantly higher in the patient group. Conclusion: Our findings suggest that the macrostructure of sleep is significantly impacted in NMOSD patients, with a higher prevalence of OSAS, hypersomnia/ narcolepsy, and RLS. To enhance the quality of life in these patients, it is crucial to investigate sleep disorders early using qualitative methods and to implement appropriate treatments at an early stage.
Citation - WoS: 15
Citation - Scopus: 15
Assessment of Mtor Pathway Molecules During Implantation in Rats
(Taylor & Francis Ltd, 2017) Ekizceli, G.; İnan, Sevinç; Oktem, G.; Onur, E.; Ozbilgin, K.
Mammalian target of rapamycin (mTOR) is a member of the PI3K/Akt/mTOR signaling pathway that participates in cell growth, proliferation, protein synthesis, transcription, angiogenesis, apoptosis and autophagy. We investigated the role of mTOR and other signaling molecules in the rat uterus during implantation. Female pregnant rats were divided into three groups: embryonic days (ED) 4.5, 5.5 and 6.5 according to vaginal smears. Immunohistochemical staining of mTORC1, mTORC2, IGF1, PI3K, pAkt1/2/3, ERK1 and pERK1/2 was performed on formalin fixed, paraffin embedded uterine tissue samples. pAkt1/2/3 and ERK1 also were analyzed using western blotting. We found that PI3K/Akt/mTOR and ERK/pERK were increased during the implantation period. Different amounts of mTORC1, mTORC2, IGF1, PI3K, pAKT1/2/3, ERK1 and pERK1/2 were expressed in luminal epithelium, decidual cells, embryoblast and trophoblast cells during implantation. We suggest that mTOR and associated signaling molecules may participate in implantation.
Citation - WoS: 8
Citation - Scopus: 13
Assistive Technologies for Visually Impaired Individuals in Turkey
(R E S N A Press, 2010) Bengisu, Murat
A phone survey was conducted with 80 visually impaired people in Turkey to understand what types of assistive products are used and to what extent. The perceived utility of selected products and reasons for nonuse were investigated. Descriptions of products that would be useful for the participants but may not be available on the market were also obtained. The three most used assistive products were found to be computer screen readers (46%), talking watches (26%), and screen readers for cellular phones (21%). Cellular phones with screen reading capability are the most desired assistive products among the visually impaired community, but their high cost is a major barrier. Most of the relevant technologies are available but some product development, such as adaptation to the Turkish language, is necessary. The three products most frequently requested are bus station/destination announcement systems, devices that warn the person about barriers, and devices that read printed documents and signs.
The Association of Polypoid Growth Pattern With Lymph Node Involvement in Endometrioid Type Endometrial Adenocarcinoma
(Wolters Kluwer Medknow Publications, 2023) Bezircioğlu, İncim; Yetimalar, M.H.; Kılıç, D.; Yiğit, S.
Background: Tumor size is an independent predictor of lymph node metastasis and survival in the endometrioid type endometrial adenocarcinoma (EC). However, some of the ECs tend to grow towards the cavity in the polypoid pattern, which can reach very large sizes. In this study, we aimed to analyze the association of growing in the polypoid pattern of the tumor with the proportion of lymph node metastasis and extrauterine tumor spread. Methods: Four hundred seven patients were analyzed retrospectively. The effect of tumor size, tumor growing pattern, myometrial invasion, grade, and lymphovascular space invasion on the lymph node metastasis and extrauterine tumor spread were investigated. Statistical analysis consisted of unpaired t-tests for parametric data and Mann Whitney-U test for non-parametric data, whereas the Chi-square test for categorical variables. Logistic Regression, Cox Regression and multivariate analysis were used to estimate the risk predictors. Results: No association was found between the growing in polypoid pattern and lymph node metastasis (P > 0.05). In the analysis of endometrioid type EC patients who had myometrial invasion less than ½ as a subgroup, no association was found between the growing pattern and lymph node metastasis and extrauterine disease. Tumor size was found to be a statistically significant predictor of lymph node metastasis and extrauterine disease (P < 0.05). Conclusions: Lymphovascular space invasion, grade, and myometrial invasion are associated with a higher proportion of lymph node metastasis. The polypoid growth pattern of the tumor does not correlate with any histopathological parameters. © 2023 Copyright:
Citation - WoS: 6
Citation - Scopus: 2
Association of Ratios of Monocyte/High-density Lipoprotein Cholesterol and Neutrophil/High-Density Lipoprotein Cholesterol With Atherosclerotic Plaque Type on Coronary Computed Tomography
(Clinics Cardive Publ Pty Ltd, 2024) Okan, T.; Topaloglu, C.
Objectives: The monocyte/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and neutrophil/HDL-C ratio (NHR) are markers for inflammation and dyslipidaemia, which are important factors in atherosclerosis. Studies have linked MHR and NHR to the prediction, severity and prognosis of coronary artery disease. However, no study has explored their connection to plaque stability, specifically its calcific or soft/mixed content. Methods: Monocyte, neutrophil and HDL-C levels were examined in 99 patients who had coronary computed tomographic angiography (CTA) between January and August 2023. They were divided into three groups: a group of 42 healthy individuals (group 0) with no coronary artery plaque and an Agatson score of 0, an unstable plaque group (group 1) with 31 patients displaying mixed and/or soft plaque on CTA, and a stable plaque group (group 2) with 26 patients showing only calcific plaque. Results: White blood cell (WBC), monocyte and neutrophil counts were significantly higher in group 1 patients compared to group 0 patients (group 0: WBC = 6.31 ± 0.97 × 103 cells/ µl, monocytes = 0.40 ± 0.09 × 103 cells/µl, neutrophils = 3.32 ± 0.81 × 103 cells/µl; and group 1: WBC = 7.61 ± 1.95 × 103 cells/µl, monocytes = 0.50 ± 0.11 × 103 cells/µl, neutrophils = 4.19 ± 1.36 103 cells/µl; p < 0.05). MHR and NHR were significantly higher in group 1 patients compared to group 0 patients (group 0: MHR = 0.0079 ± 0.0029, NHR = 0.063 ± 0.023 and group 1: MHR = 0.0102 ± 0.003, NHR = 0.085 ± 0.036, p < 0.05). Conclusion: The significant differences in MHR and NHR between the three groups were due to the differences between groups 0 and 1. MHR and NHR were significantly higher in group 1 patients, although there was no statistically significant difference between groups 1 and 2. Copyright © 2024 Clinics Cardive Publishing. All Rights Reserved.

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