Browsing by Author "Feys, Peter"

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Different Gait Dynamics and Distance Walking/Gait Quality Fatigability Manifestation During the 6-Minute Walking in People With Multiple Sclerosis
(Sage Publications Ltd, 2024) Santinelli, Felipe Balistieri; Ramari, Cintia; Abasiyanik, Zuhal; Gysemberg, Griet; Kos, Daphne; Ozakbas, Serkan; Feys, Peter
Citation - WoS: 6
Citation - Scopus: 8
Manifestations of Walking Fatigability in People With Multiple Sclerosis Based on Gait Quality and Distance Walked During the Six Minutes Walking Test
(Elsevier B.V., 2024) Santinelli, F.B.; Abasıyanık, Z.; Ramari, C.; Gysemberg, G.; Kos, D.; Pau, M.; Kalron, A.; Özakbaş, Serkan; Feys, Peter
Background: Distance walking fatigability (DWF) in people with multiple sclerosis (pwMS) is defined as a decrease in the distance walking over time. However, declines in gait quality (i.e., gait quality fatigability- GQF) may occur independently or alongside DWF. Objective: i) to investigate how walking fatigability manifests and its prevalence in pwMS; ii) to describe the temporal pattern of the changes of specific gait characteristics during the 6-minute walking test (6MWT) Methods: Eighty-eight pwMS (EDSS 4[0–6.5], 49[21–70] years) and 47 healthy controls (HC- 46[25–60] years) performed the 6MWT wearing inertial measurement units. Gait characteristics (stride length, sensor-based gait speed, cadence, double support, step duration, stance phase, step duration asymmetry, step duration variability, foot-strike, toe-off, and leg circumduction) and walking distance were recorded in 1-minute intervals. A fatigability index was calculated by comparing the last and first minute of the 6MWT to identify abnormal worsening based on cutoff scores. The manifestation of walking fatigability was counted. The temporal pattern of worsening of gait characteristics during the 6MWT was examined in pwMS exceeding the cutoff values, compared to pwMS without abnormal changes and HC, using a two-way ANOVA (group vs. minutes) Results: Thirty-five pwMS presented both DWF and GQF, 2 presented isolated DWF, 27 presented isolated GQF, and 24 presented non-walking fatigability. PwMS having GQF presented worsening in gait characteristics (cadence, step duration, step duration variability, or toe-off angle) from minute 2 onwards of the 6MWT, while HCs and pwMS without abnormal changes stabilized gait from minute 2 towards the end of the 6MWT. Conclusion: Walking fatigability in pwMS manifests not only as a decrease in walking distance but also as changes in gait quality. Understanding changes in gait characteristics during walking can help tailor rehabilitation interventions. © 2024 Elsevier B.V.
Perceived and Performed Dual-Task Ability in Persons With Multiple Sclerosis: an International Multi-Centered Study
(Sage Publications Ltd, 2024) Abasiyanik, Zuhal; Pedulla, Ludovico; Soler, Bernardita; Santoyo-Medina, Carme; Kahraman, Turhan; D'Hooge, Mieke; Tacchino, Andrea; Feys, Peter
[No abstract available]
Prevalence and Magnitude of Distance Walking Fatigability in People With Multiple Sclerosis
(Sage Publications Ltd, 2024) Santinelli, Felipe Balistieri; Abasiyanik, Zuhal; Dalgas, Ulrik; Ozakbas, Serkan; Severijns, Deborah; Gebara, Benoit; Maamagi, Heigo; Feys, Peter
[No abstract available]
Citation - Scopus: 1
Prevalence and Magnitude of Perceived Dual-Task Difficulties in People with Multiple Sclerosis: An International Study
(W.B. Saunders, 2025) Abasıyanık, Z.; Pedullà, L.; Kahraman, T.; Soler, B.; Santoyo-Medina, C.; Tacchino, A.; D'Hooge, M.; Feys, Peter
Objective: To investigate the prevalence and magnitude of dual-task (DT) difficulties and the discriminative ability of 3 questionnaires evaluating perceived DT difficulties: the Dual-Tasking Questionnaire (DTQ), Dual-Task Screening List (DTSL), and Dual-task Impact on Daily life Activities Questionnaire (DIDA-Q). Design: Multicenter, cross-sectional study. Setting: Persons with multiple sclerosis (pwMS) and those without multiple sclerosis were recruited from 7 centers across 6 countries. Participants: A total of 540 participants (N=540): 175 with mild disability (mean Expanded Disability Status Scale, 2.1; mean age, 42.9), 181 with moderate-to-severe disability (mean Expanded Disability Status Scale, 5.3; mean age, 51.9), and 184 of those without multiple sclerosis (mean age, 44.8). Interventions: Not applicable. Main Outcome Measures: The cutoff scores of the DTQ, DTSL, and DIDA-Q and prevalence of DT difficulties were calculated. The effect size (ES) was calculated to determine the magnitude of the differences between groups (pwMS vs those without multiple sclerosis). The discriminative properties were identified by the area under the receiver operating characteristic curve (AUC). Cutoff values were estimated as the mean survey score plus 2 SDs of those without multiple sclerosis. Results: Prevalence ranged from 49%-87% in the moderate-to-severe disability and 25%-45% in the mild disability group. The cutoff scores were 45 of 100 for DTQ, 25 of 100 for DTSL, and 14 of 76 for DIDA-Q. The DTQ (ES, 0.61), DTSL (ES, 0.73), and DIDA-Q (ES, 0.80) demonstrated discriminative ability with a moderate-to-large ES, showing greater perceived DT difficulties in pwMS compared with those without multiple sclerosis. The DIDA-Q had the largest AUC (0.904) compared with DTSL (0.866), and DTQ (0.802). Conclusions: The DT difficulties were already perceived in almost half of the mildly disabled patients and increased with disability severity. The DTQ, DTSL, and DIDA-Q show discriminative ability, with the highest AUC and ES observed in DIDA-Q. The DTQ, DTSL, and DIDA-Q can clearly be used in pwMS for clinical and research purposes. © 2025 Elsevier B.V., All rights reserved.
Prevalence of Distance Walking Fatigability in Multiple Sclerosis According to MS Phenotype, Disability Severity and Walking Speed
(Elsevier France-Éditions Scientifiques Médicales Elsevier, 2025) Santinelli, Felipe Balistieri; Abasiyanik, Zuhal; Dalgas, Ulrik; Ozakbas, Serkan; Severijns, Deborah; Gebara, Benoit; Feys, Peter
Citation - WoS: 1
Citation - Scopus: 3
Reliability and Construct Validity of Three Self-Report Questionnaires Assessing Dual-Task Difficulties in People With Multiple Sclerosis: an International Study
(W B Saunders Co-elsevier inc, 2025) Abasiyanik, Zuhal; Pedulla, Ludovico; Kahraman, Turhan; D'Hooge, Mieke; Santoyo-Medina, Carme; Soler, Bernardita; Feys, Peter
Objective: To evaluate the reliability and validity of the dual-tasking questionnaire (DTQ), dual-task screening list (DTSL), and dual-task impact on daily life activities questionnaire (DIDA-Q). Design: Multicenter, cross-sectional study Setting: Persons with multiple sclerosis (pwMS) were recruited from 7 multiple sclerosis centers across 6 countries (Belgium, Chile, Italy, Israel, Spain, and Turkey). Participants: A total of 356 pwMS (mean age 47.5 +/- 11.5y, expanded disability status scale, 3.79 +/- 1.83) were enrolled. Interventions: Not applicable Main Outcome Measures: The reliability (internal consistency, test-retest, and measurement error) and construct validity (structural and convergent) were assessed. Results: The DTQ, DTSL, and DIDA-Q demonstrated excellent test-retest reliability (intraclass correlation coefficients [95% CI], 0.84 [0.80-0.87] to 0.90 [0.87-0.92]) and internal consistency (Cronbach a: 0.86-0.96). As hypothesized, the 3 questionnaires showed a strong correlation with each other, moderate-to-strong correlations with other self-report questionnaires (perceived walking difficulties, fatigue, and fear of falling), and low- to-moderate correlations with cognitive information processing speed, manual dexterity, and dual-task walking performance (walking with word list generation task), showing convergent validity. The DIDA-Q exhibited systematically superior properties. These results were also verified in subsets from 6 different countries. In the structural validity analysis, all questionnaires displayed 2 main factors, allocated as "motor-driven" and "cognitive-driven" subscales. Conclusions: The DTQ, DTSL, and DIDA-Q have good-to-excellent measurement properties, with the highest properties observed in DIDA-Q. The use of these self-reported questionnaires can be used in research and clinical practice to assess the effect of dual-task difficulties on the daily life of ambulatory pwMS. (c) 2024 by the American Congress of Rehabilitation Medicine.
Sustained Attention and Gait Pattern Changes During the 6-Minute Walk Test in Persons with Multiple Sclerosis
(Lippincott Williams & Wilkins, 2025) Abasiyanik, Zuhal; Kahraman, Turhan; Veldkamp, Renee; Ertekin, Ozge; Kalron, Alon; Ozakbas, Serkan; Feys, Peter
Background and purpose: It is unknown whether persons with multiple sclerosis (pwMS) can retain sustained attention and gait quality during long-distance walking tests. This study aimed to investigate changes in sustained attention and gait parameters during prolonged walking in pwMS with different levels of disability and healthy controls (HCs) and correlations of these changes with self-reported daily life difficulties. Methods: The 6-Minute Walk Test was performed with an auditory sustained attention task while wearing inertial measurement sensors. Participants were asked to respond verbally as quickly as possible to randomly presented auditory stimuli during 6 minutes of walking. The accuracy of answers, average reaction time, and gait parameters per minute were determined. Results: Thirty pwMS with mild disability (Expanded Disease Status Scale [EDSS] < 4.0), 16 pwMS with moderate-to-severe disability (EDSS 4.0 to 6.5), and 27 age-gender matched HCs were included. A significant group-by-time interaction effect as found for reactions times, which increased in mild and moderate-to-severe disability groups but not in HCs. Gait parameters deteriorated over time in all groups, but no significant group-by-time interaction was found. The decrease in sustained attention was not related to changes in gait or clinical outcomes, while deterioration in gait parameters was associated with perceived walking disability and dual-task difficulties in daily life. Discussion and Conclusions: Sustained attention during walking declined over time in pwMS, but not in HCs. However, gait parameters deteriorated in all groups. Worsening gait during simultaneous cognitive task execution may contribute to walking and dual-task difficulties in pwMS.