PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/2
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Browsing PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection by Journal "Acta Neurologica Belgica"
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Article Pain in Neuromyelitis Optica Spectrum Disorder: Determination of Prevalence and Characteristics(Springer Heidelberg, 2025) Ozdogar, Asiye Tuba; Yesiloglu, Pervin; Unal, Gozde Deniz; Engenc, Veysel; Zengin, Ela Simay; Cilingir, Vedat; Ozakbas, SerkanIntroduction The aim was to determine the prevalence and characteristics of pain in people with neuromyelitis optica spectrum disorders (pwNMOSD).
Methods The Nordic Musculoskeletal Questionnaire (NMQ) was used to determine the participants' pain levels and pain localization. The PainDETECT Questionnaire (PD-Q) was used to differentiate between nociceptive and neuropathic pain. The scores <= 12 were considered as presence of musculoskeletal pain (MSP) and > 12 as neuropathic pain (NP). The Preference-Based Multiple Sclerosis Index (PBMSI) was used to measure health-related quality of life. Information such as Expanded Disability Status Scale (EDSS), disease duration and age of the participants were also recorded.
Results The 62 participants included in the study were divided into 3 groups: 14 without pain, 17 with MSP and 31 with NP. There was no difference between the groups in terms of age, disease duration and EDSS scores (p > .05). When the pain distribution was analyzed, the regions with the most pain complaints in the last 12 months were neck (n = 22, 34.9%), foot-ankle (n = 16, 25.4%) and back (n = 15, 25.8%), respectively. When the quality of life of the three groups were compared, there was a difference between PBMSI-Walk, PBMSI-Fatigue and total score.
Conclusion The results of this study showed that the neck, back, and foot-ankle were the most common and most disabling pain areas in pwNMOSD, regardless of the age, disease duration, and EDSS score of the participant. However, there was a difference between the groups in the parameters related to gait, fatigue and total quality of life against NP.Article Citation - WoS: 5Citation - Scopus: 5The Relationship Between Work Difficulties and Physical Disability, Cognitive and Social Cognitive Impairment and Subcortical Gray Matter Atrophy in Persons With Multiple Sclerosis(Springer Heidelberg, 2024) Aslan, Taha; Ozdogar, Asiye Tuba; Sagici, Ozge; Ozakbas, SerkanBackground Multiple sclerosis (MS) is commonly associated with work difficulties. This study aimed to examine the relationship between work difficulties and physical disability, cognitive and social cognitive impairment, and subcortical gray matter (scGM) atrophy in pwMS. Methods Thirty-three employees with MS underwent assessments with Multiple Sclerosis Work Difficulties Questionnaire-23 MSWDQ-23. Physical disability was measured using EDSS, Timed 25-Foot Walk (T25FW), 2-Minute Walking Test (2-MWT), the Nine-Hole Peg test (N-HPT), and 12-item Multiple Sclerosis Walking Scale (MSWS-12). Cognitive functions were evaluated with Brief International Cognitive Assessment in MS (BICAMS), social cognition with Facial Emotion Identification (FEI), Reading the Mind in the Eyes Test (RMET), and Empathy Quotient (EQ). Anxiety and depression were assessed using Hospital Anxiety and Depression Scale (HADS). The association between variables was analysed using Spearman's correlation coefficient. GM volumes were calculated from 3T MRI data using Freesurfer, their potential relationship with work difficulties were evaluated through a linear regression model. Results MSWDQ-23 was strongly correlated with T25FW and MSWS-12 (p<0.01), moderately correlated with EDSS, 2MWT, HAD, BICAMS, and EQ (p<0.05). According to the linear regression model the decrease in volumes of total GM and scGM, bilateral Thalamus, bilateral Hippocampus, left Putamen, and right Caudate related with the severity of work difficulties (R-2=0.815, p=0.25). Conclusion This study provides valuable insights into the multifaceted nature of work difficulties experienced by pwMS. It suggests that not only physical disability but also other factors, such as mood, cognition, empathy, and cortical and subcortical gray matter atrophy may contribute to work difficulties among pwMS.
