01. Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed

Permanent URI for this communityhttps://hdl.handle.net/20.500.14365/1

Browse

Browsing 01. Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed by Language "fa"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Article
    Hemophilia A Haplotypes in Southwestern Iran
    (Bushehr University of Medical Sciences, 2025) Dehdezi, B.K.; Khodadadi, A.; Kia, A.F.; Abbasi, F.; Bitraf, S.; Kahyesh, R.S.
    Background: Hemophilia A has received attention in Iran due to its significant patient population and number of complications and comprises a major healthcare challenge in the southwestern region. Several factors contribute to the prevalence and incidence of hemophilia A in southwest- ern Iran, including genetic predisposition, consanguineous marriages, and limited access to com- prehensive healthcare services. This study aimed to investigate the common haplotypes of he- mophilia A in this region of our country. Materials and Methods: Medical record data of patients with hemophilia A over 14 years from 2009 to 2023 were entered into a questionnaire, including age, gender, form or severity of the disease, the most common bleeding site, survival rate, cause of death, place of residence, blood type, ethnicity, family relationship, and mutation type. The severity of the disease was determined based on the results of the patient's factor VIII levels, and the mutation type was determined based on molecular testing and sequencing (mutation determination by direct method or gene linkage study, including VNTR). Results: Of the 40 patients in this study, three were female (7.5%), and 37 were male (92.5%). The most common disease form was severe. In 39 patients, the most common bleeding site was in the joints, and only one case had bleeding in the gastrointestinal tract. A high mutation diversity was observed in gene mutations and inversions; the most reported case was intron-22 gene inversion. Conclusion: Identifying genetic mutations in hemophilia disease helps promote the clinical care available for these patients. Genetic testing is also indicated for carrier identification and prena- tal diagnosis. © 2025 Bushehr University of Medical Sciences. All rights reserved.
  • Thumbnail Image
    Article
    Urinary Infections in Children and Adults with Various Malignancies
    (Bushehr University of Medical Sciences, 2024) Salehi Kahyesh, R.; Holakou, A.; Bitaraf, S.; Naseri, N.; Farhadi Kia, A.
    Background: Urinary tract infection is one of the most common diseases in patients with cancer, making them at risk of developing opportunistic infections. Materials and Methods: A total of 110 samples from cancer patients admitted to Baqaei 2 Hospital in Ahvaz, including 55 chil-dren with malignancies and 55 adult patients, were included in the study. A questionnaire was completed with demographic items such as age, gender, type of malignancy, length of hospitalization, duration of chemotherapy and type of urinary tract infection along with an antibiogram susceptibility test (disc diffu-sion). Results: The mean age of the adult patients was 40.43±25.3 years, and the children 14.56±4.63 years. A total of 56 patients (50.9%) were male and 54 (49.1%) were female. The most frequent types of malignancy were: Leukemia, lung cancer, breast cancer, and colon cancer; the lowest frequency pertained to bladder, cerebellum, brain, uterine, and skin cancer. The mean minimum length of hospitalization of the patients was 1 day, and the maximum 21 days. In this study, no significant relationship was observed between the use of catheters and urinary infection, and Escherichia coli and Proteus were the most common bacterial infections in this category of patients. A significant relationship was observed between using a urinary catheter and the volume of excretion of RBC, WBC, and epithelial cells. A higher-than-normal WBC count alone does not confirm infection. Conclusion: Pathogens were the most common bacteria separated from the patients with malignancies in this research, which can have dangerous and fatal complications for the patient. It is therefore vital to monitor these patients for urinary infections. © 2024 Bushehr University of Medical Sciences. All rights reserved.