PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/2

Browse

Now showing 1 - 20 of 327

Citation - WoS: 2
Citation - Scopus: 2
Adjuvant Action of Needle-Shaped Bc Microfibrils
(Springer, 2023) Sür, Özge; Gül, Aytul; Hames, Elif Esin
Bacterial cellulose (BC) is an unbranched biopolymer produced by microorganisms and composed of glucopyranose units linked by beta-1,4 bonds. This study investigates the adjuvant action of needle-shaped BC microfibrils (BCmFs) in vitro using bovine serum albumin (BSA) as a model antigen. BC produced by the static culture of Komagataibacter xylinus was then microparticled (1-5 mu m) by acid hydrolysis and characterized using Dynamic Light Scattering and Scanning Electron Microscopy. Subsequently, Attenuated Total Reflectance-Fourier-Transform Infrared Spectroscopy, cytotoxicity, TNF-alpha (tumour necrosis factor-alpha) and IL-6 (interleukin-6) cytokine secretion, and cellular uptake of the BCmFs-BSA conjugate on the human monocyte cell line (U937) differentiated into macrophages were performed. The microfibrils were determined to be 1-5 mu m in size, needle-shaped, with a zeta potential of - 32 mV. Their conjugation with the model antigen, BSA, was demonstrated by FTIR analysis. In the cytotoxicity assay, BCmFs-BSA in macrophage cells showed high viability (over 70%). Although the highest TNF-alpha cytokine level (113 pg/ml) was obtained with BCmFs-BSA (Bovine serum albumin) conjugate (500 mu g/ml) and was statistically significant (p = 0.0001) compared to the positive control group (BSA-aluminium hydroxide), IL-6 cytokine levels were not statistically different from those in the control group as desired. It has been shown in macrophage-differentiated U937 cells that microbially synthesized BC in the form of needle-shaped microfibrils (BCmFs) has a high cellular uptake capacity and increases the immunogenicity of the antigen. These results demonstrate for the first time that BCmFs have the potential to serve as a vaccine adjuvant.
Citation - WoS: 4
Citation - Scopus: 5
Advanced Nurse-Patient Communication System
(Springer, 2012) Unluturk, Mehmet S.
Effective communication is the most important part of any healthcare organization. For many years, hospital nurse call solutions had been stand-alone systems with occasional integration to pocket paging for outputting patient call alerts to mobile staff. In the late 1990's, technology enabled in-building wireless phones to supplement or replace paging systems as a means of not only sending alerts, but also enabling voice communication between mobile staff and patients. Today's nurse call market requires integration of additional information from location and ADT (admit, discharge, transfer) systems into what have traditionally been nurse call applications. This system information is required not only at the nursing station, pagers, and phones, but also at PC's placed on each patient care floor in hallways, nurse stations, and offices, and at areas away from the patients, including administrator and clinical engineering offices. It is crucial that nurses have the latest patient information in their hand wherever they go in the hospital. In this paper, MatchMaker.NET has been developed to integrate all these technologies into the hospital's LAN to improve nurse-patient communication.
Citation - WoS: 10
Citation - Scopus: 9
Advancements in Platinum Chemotherapy for Metastatic Castration-Resistant Prostate Cancer: Insights and Perspectives
(ELSEVIER SCI LTD, 2024) Akkuş, Erman; Arslan, Çağatay; Ürün, Yüksel
Despite improvements in survival, metastatic castration-resistant prostate cancer (mCRPC) remains a significant clinical challenge. While taxanes, new hormonal agents, radiopharmaceuticals, and PARP inhibitors offer valuable treatment options, this review explores the potential of platinum chemotherapies (carboplatin, cisplatin, and oxaliplatin) as alternative choices. Existing research demonstrates promising preliminary results for platinum-based therapies in mCRPC showing PSA response rates (7.7-95 %) and improved overall survival (8-26.6 months). However, chemotherapy-related cytopenias are a frequent side effect. Further research is underway to evaluate the efficacy of platinum regimens against specific mCRPC histopathological variants, particularly aggressive subtypes where the carboplatin and cabazitaxel combination is already recommended. The unique DNA-targeting action of platinum therapy holds promise for patients with deficient DNA repair (dDDR), especially those with BRCA mutations. This potential is supported by both preclinical and ongoing clinical research. Given the limited success of immunotherapy in mCRPC, researchers are exploring the potential for platinum therapies to enhance its efficacy. Additionally, trials are investigating the synergy of combining platinum therapy with both immunotherapy and PARP inhibitors. Further exploration into the effectiveness of platinum therapies in specific mCRPC subpopulations, particularly those with dDDR, is crucial for optimizing their future use. In conclusion, this review highlights the promising potential of platinum-based chemotherapy as a valuable treatment option for mCRPC. While current evidence is encouraging, ongoing research is essential to further optimize its efficacy, identify optimal combinations with other therapies, and better understand its impact on specific mCRPC subpopulations.
Citation - WoS: 94
Citation - Scopus: 103
Affective Interpersonal Touch in Close Relationships: a Cross-Cultural Perspective
(Sage Publications Inc, 2021) Sorokowska, Agnieszka; Saluja, Supreet; Sorokowski, Piotr; Frackowiak, Tomasz; Karwowski, Maciej; Aavik, Toivo; Akello, Grace; Can, Seda
Interpersonal touch behavior differs across cultures, yet no study to date has systematically tested for cultural variation in affective touch, nor examined the factors that might account for this variability. Here, over 14,000 individuals from 45 countries were asked whether they embraced, stroked, kissed, or hugged their partner, friends, and youngest child during the week preceding the study. We then examined a range of hypothesized individual-level factors (sex, age, parasitic history, conservatism, religiosity, and preferred interpersonal distance) and cultural-level factors (regional temperature, parasite stress, regional conservatism, collectivism, and religiosity) in predicting these affective-touching behaviors. Our results indicate that affective touch was most prevalent in relationships with partners and children, and its diversity was relatively higher in warmer, less conservative, and religious countries, and among younger, female, and liberal people. This research allows for a broad and integrated view of the bases of cross-cultural variability in affective touch.
Citation - WoS: 6
Citation - Scopus: 6
Agreement Between Tele-Assessment and Face-To Assessment of 30-S Sit-To Test in Patients With Type 2 Diabetes Mellitus
(Springer London Ltd, 2023) Aktan, Ridvan; Yilmaz, Hayriye; Demir, Ismail; Ozalevli, Sevgi
Background The globalization of healthcare systems, and the aim to lower healthcare costs have all contributed to the growth of telehealth technology in recent years. However, before these systems are put into use, their efficacy should be verified. To the best of our knowledge, this is the first study focusing on the evaluation of functional exercise capacity using the 30-s sit-to-stand (30-s STS) test as a tele-assessment method in patients with type 2 diabetes mellitus (T2DM). Aims The purpose of the study is to investigate the level of agreement between tele-assessment and face-to-face assessment of 30-s STS test in patients with T2DM. Methods Fifty participants performed two times 30-s STS tests separated by 1 h: a face-to-face and an Internet-connected video call examination (tele-assessment). Two physiotherapists conduct these evaluations; each was blinded to the other. The order of the evaluations was designated at random for each participant and physiotherapist. Results There was a good level of agreement between tele-assessment and face-to-face assessment of the 30-s STS test (mean differences = 0.20 +/- 0.88, limits of agreement =1.93 to - 1.53). Excellent interrater reliability was found for scores of the 30-s STS test [ICC = 0.93 (95% CI: 0.88; 0.96)]. In addition, all before and after test parameters show that there was a very good interrater reliability (rho >= 0.75). Conclusions This study shows a good level of agreement between tele-assessment and face-to-face assessment of the 30-s STS test. Our study's findings indicate that tele-assessment is a potential application to determine the level of physical capacity remotely in patients with T2DM.
Citation - WoS: 10
Citation - Scopus: 11
Alzheimer's Disease Research Progress in the Mediterranean Region: the Alzheimer's Association International Conference Satellite Symposium
(Wiley, 2022) Sexton, Claire; Solis, Michele; Aharon-Peretz, Judith; Alexopoulos, Panagiotis; Yener, Görsev; Bayen, Eleonore; Birkenhager, Betty
As research and services in the Mediterranean region continue to increase, so do opportunities for global collaboration. To support such collaborations, the Alzheimer's Association was due to hold its seventh Alzheimer's Association International Conference Satellite Symposium in Athens, Greece in 2021. Due to the COVID-19 pandemic, the meeting was held virtually, which enabled attendees from around the world to hear about research efforts in Greece and the surrounding Mediterranean countries. Research updates spanned understanding the biology of, treatments for, and care of people with Alzheimer's disease (AD_ and other dementias. Researchers in the Mediterranean region have outlined the local epidemiology of AD and dementia, and have identified regional populations that may expedite genetic studies. Development of biomarkers is expected to aid early and accurate diagnosis. Numerous efforts have been made to develop culturally specific interventions to both reduce risk of dementia, and to improve quality of life for people living with dementia.
Alzheimer's Imaging Consortium
(2025) Gonzalez-Gomez, R.; Hernandez, H.; Migeot, J.; Cruzat, J.; Legaz, A.; Fittipaldi, S.; Ibáñez, A.
BACKGROUND: While education is crucial for brain health, evidence mainly relies on individual measures of years of education (YoE), neglecting educational quality (EQ). Whether YoE and EQ have complementary impacts on aging and dementia is unknown. METHODS: We assessed the impact of EQ and YoE on brain health in 7,533 subjects from 20 countries, including healthy controls (HCs), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). EQ was based on country-level quality indicators. After applying neuroimage harmonization, we examined their effect on gray matter volume and functional connectivity. Regression models were adjusted for age, sex, and cognition, controlling for multiple comparisons. The impact of image quality was controlled through sensitivity analysis. RESULTS: Less EQ and YoE were associated with greater brain burden across groups. However, EQ had a stronger impact, mainly targeting the vulnerable areas of each condition. At the whole-brain level, EQ influenced atrophy (HCs: ∆mean = 2.0 [1.9-2.0] CL95 × 10⁻², p < 10⁻⁵; AD: ∆mean = 0.1 [-0.0-0.3] CL95 × 10⁻², p = 0.18; FTLD: ∆mean = 3.5 [3.0-4.0] CL95 × 10⁻², p < 10⁻⁵) and networks (HCs: ∆mean = 13.5 [13.2-13.7] CL95 × 10⁻², p < 10⁻⁵; AD: ∆mean = 5.9 [5.2-6.7] CL95 × 10⁻², p < 10⁻⁵; FTLD: ∆mean = 13.2 [11.2-13.7] CL95 × 10⁻², p < 10⁻⁵), 1.3 to 7.0 times more than YoE. CONCLUSION: Results support the need to incorporate education quality to study and improve brain health, underscoring the importance of country-level measures. © 2025 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Citation - WoS: 112
Citation - Scopus: 130
Analysis of High-Dimensional Phase Space Via Poincare Section for Patient-Specific Seizure Detection
(IEEE-Inst Electrical Electronics Engineers Inc, 2016) Zabihi, Morteza; Kiranyaz, Serkan; Rad, Ali Bahrami; Katsaggelos, Aggelos K.; Gabbouj, Moncef; İnce, Türker
In this paper, the performance of the phase space representation in interpreting the underlying dynamics of epileptic seizures is investigated and a novel patient-specific seizure detection approach is proposed based on the dynamics of EEG signals. To accomplish this, the trajectories of seizure and nonseizure segments are reconstructed in a high dimensional space using time-delay embedding method. Afterwards, Principal Component Analysis (PCA) was used in order to reduce the dimension of the reconstructed phase spaces. The geometry of the trajectories in the lower dimensions is then characterized using Poincare section and seven features were extracted from the obtained intersection sequence. Once the features are formed, they are fed into a two-layer classification scheme, comprising the Linear Discriminant Analysis (LDA) and Naive Bayesian classifiers. The performance of the proposed method is then evaluated over the CHB-MIT benchmark database and the proposed approach achieved 88.27% sensitivity and 93.21% specificity on average with 25% training data. Finally, we perform comparative performance evaluations against the state-of-the-art methods in this domain which demonstrate the superiority of the proposed method.
An Analysis of Sample Size Calculations in Randomized Control Trials in Emergency Medicine
(W B Saunders Co-Elsevier Inc, 2025) Limon, Onder; Dogan, Nurettin Ozgur; Limon, Gulsum; Aksay, Ersin
Introduction: Sample size calculation enhances the quality of randomized clinical trials (RCTs) and, according to the CONSORT statement, should be reported and justified in published articles. This study aimed to evaluate the current quality of sample size calculation reporting in RCTs published in emergency medicine journals. Methods: The Web of Science (WoS) database was used for article retrieval. Journals indexed in WoS, published in English, categorized under "emergency medicine," and ranked in Q1 were included in the search. The sample size calculation method, power value, alpha value, effect size, and consideration of missing data were evaluated. Results: A total of 252 RCTs from 12 emergency medicine journals were included in the study. Only 30% of the articles explicitly stated compliance with CONSORT guidelines. Sample size calculations were reported in 84% of the articles. Alpha values were omitted in 12 % and beta (power) values in 8% of the articles. Effect sizes were not reported in 90 % of the studies. Notably, 11 % of the articles claiming CONSORT compliance did not include a sample size analysis. In the logistic regression analysis, none of the variables showed a statistically significant association with the presence of sample size analysis. Conclusion: Although emergency medicine journals show relatively better adherence to sample size calculation reporting compared to some other disciplines, their overall performance remains suboptimal. The findings highlight ongoing and significant deficiencies in the quality of RCT reporting, indicating that even leading journals in the field fall short of fully meeting recommended standards. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
The Anatomy of a Decision: Exploring the Push, Pull, and Personal Factors of Emigration Intent Among Turkish Medical Students
(BMC, 2025) Aydin, Mevlut Okan; Caliskan, S. Ayhan; Ozkaya, Guven; Kumtepe, A. Sila; Aydin, Birnur; Alper, Zuleyha
BackgroundThe migration intentions of medical students, often referred to as "brain drain," pose a significant challenge to healthcare systems worldwide. This study aims to investigate the motivations for emigration, career preferences, and preparatory actions among medical students in T & uuml;rkiye, a country experiencing significant physician outflow. Methods A cross-sectional online survey was distributed to medical students across T & uuml;rkiye. The final sample included 1134 participants from 20 different medical faculties. Data were collected on demographics, motivations for studying medicine, specialty preferences, language proficiency, international experience, and intentions and preparations for working abroad or domestically. Results Motivations for studying medicine and specialty preferences differed significantly by gender. Female students were more driven by altruism and preferred nonsurgical specialties, whereas male students prioritized financial prospects, prestige, and surgical fields. The key predictors for intending to work abroad included higher parental education, advanced foreign language proficiency (especially English), and prior international experience. A third of the students (33%) expressed a desire to work abroad after graduation, with Germany, the UK, and the US being the top destinations. The primary push factors for emigration were demanding working conditions (70.8%), violence against healthcare professionals (64.1%), and systemic problems within the healthcare system (55.8%). A striking finding was 74.2% of the students who planned to stay in T & uuml;rkiye were also making preparations to leave, indicating a deep-seated lack of confidence in the domestic healthcare environment. Conclusion A significant proportion of Turkish medical students intend to practice abroad, driven primarily by push factors related to working conditions and safety. The widespread preparatory activities, even among those stating an intention to stay, suggest that brain drain is a tangible risk. Retaining this future physician workforce requires urgent, systemic interventions addressing working conditions, safety from violence, and career opportunities, particularly in research and academic medicine.
Citation - WoS: 40
Citation - Scopus: 46
Animals as Mobile Biological Sensors for Forest Fire Detection
(Mdpi, 2007) Sahin, Yasar Guneri
This paper proposes a mobile biological sensor system that can assist in early detection of forest fires one of the most dreaded natural disasters on the earth. The main idea presented in this paper is to utilize animals with sensors as Mobile Biological Sensors (MBS). The devices used in this system are animals which are native animals living in forests, sensors (thermo and radiation sensors with GPS features) that measure the temperature and transmit the location of the MBS, access points for wireless communication and a central computer system which classifies of animal actions. The system offers two different methods, firstly: access points continuously receive data about animals' location using GPS at certain time intervals and the gathered data is then classified and checked to see if there is a sudden movement (panic) of the animal groups: this method is called animal behavior classification (ABC). The second method can be defined as thermal detection (TD): the access points get the temperature values from the MBS devices and send the data to a central computer to check for instant changes in the temperatures. This system may be used for many purposes other than fire detection, namely animal tracking, poaching prevention and detecting instantaneous animal death.
Citation - WoS: 27
Citation - Scopus: 35
Artificial Intelligence and Radiomics in Nuclear Medicine: Potentials and Challenges
(Springer, 2019) Aktolun, Cumali
Artificial intelligence involves a wide range of smart techniques that are applicable to medical services including nuclear medicine. Recent advances in computer power, availability of accumulated digital archives containing large amount of patient images, and records bring new opportunities for the implementation of artificial techniques in nuclear medicine. As a subset of artificial intelligence, machine learning is an emerging tool that can possibly perform many clinical tasks. Nuclear medicine community needs to adapt to this fast approaching smart era, to exploit the opportunities and tackle the problems associated with artificial intelligence tools. It is aimed in this editorial to outline the opportunities and challenges of artificial intelligence applications in nuclear medicine.
Artificial Intelligence and Radiomics in Nuclear Medicine: Potentials and Challenges (vol 46, Pg 2731, 2019)
(Springer, 2020) Aktolun, Cumali
[Abstract Not Available]
Citation - WoS: 11
Citation - Scopus: 11
Assessing Safety and Efficacy of Tnfi Treatment in Late Onset Ankylosing Spondylitis: a Turkbio Registry Study
(Nature portfolio, 2024) Uslu, Sadettin; Gülle, Semih; Şen, Gercek; Cefle, Ayşe; Yılmaz, Sema; Koçer, Sinem Burcu; Yüce İnel, Tuba
Clinical data on the use of tumour necrosis factor inhibitors (TNFi) in late-onset ankylosing spondylitis (LoAS) are limited. The present study aimed to evaluate efficacy, safety, and treatment adherence associated with the initial use of TNFi therapy in biologic naive patients diagnosed with LoAS. Patients whose age of onset was >= 45 years and < 45 years were classified as having LoAS and YoAS, respectively, based on the age of symptom onset. There were 2573 patients with YoAS and 281 LoAS. Baseline disease activity measures were similar between the groups. No significant differences were seen between the two groups in response to treatment and in remaining on the first TNFi at 6, 12 and 24 months. In the LoAS group, the analysis showed that TNFi discontinuation was linked to VAS pain score (HR 1.04; 95% CI 1.01-1.06). Patient groups had similar rates of adverse events (YoAS: 8.7% vs. LoAS: 11.7%). In both biologic naive LoAS and YoAS patients, the study showed that the initial TNFi therapy was equally effective and safe.
Citation - WoS: 8
Citation - Scopus: 13
Assistive Technologies for Visually Impaired Individuals in Turkey
(R E S N A Press, 2010) Bengisu, Murat
A phone survey was conducted with 80 visually impaired people in Turkey to understand what types of assistive products are used and to what extent. The perceived utility of selected products and reasons for nonuse were investigated. Descriptions of products that would be useful for the participants but may not be available on the market were also obtained. The three most used assistive products were found to be computer screen readers (46%), talking watches (26%), and screen readers for cellular phones (21%). Cellular phones with screen reading capability are the most desired assistive products among the visually impaired community, but their high cost is a major barrier. Most of the relevant technologies are available but some product development, such as adaptation to the Turkish language, is necessary. The three products most frequently requested are bus station/destination announcement systems, devices that warn the person about barriers, and devices that read printed documents and signs.
Citation - WoS: 8
Citation - Scopus: 9
The Association Between Mobile Phone Usage Duration, Neck Muscle Endurance, and Neck Pain Among University Students
(NATURE PORTFOLIO, 2024) Elvan, Ata; Çevik, Şeval; Vatansever, Kivanc; Erak, İlknur
The mobile phone is essential in daily life, especially during the pandemic. Prolonged use can cause postural issues, leading to common neck pain. This study aims to determine the correlation between mobile phone use duration, addiction, neck muscle endurance, and neck pain in university students. The study included 62 participants (30 female, 32 male) aged 18-35 years. Inclusion criteria required participants to have experienced neck pain at least twice in the past year and to have no other concomitant issues, as well as to volunteer for the study. Demographic information and daily mobile phone usage time were collected. Neck pain was assessed with the Visual Analogue Scale, smartphone addiction with the Smartphone Addiction Scale, and cervical muscle endurance was evaluated. Correlation analysis reveals a moderate relationship between neck pain severity (NPS) and cervical extensor muscle endurance (CEME), a strong relationship between NPS and cervical flexor muscle endurance (CFME), as well as a strong relationship among daily phone usage time (DPUT), CFME, and NPS, with a moderate relationship between DPUT and CEME. Participants were divided into two groups based on their DPUT, revealing that those who used their phone for four hours or more showed significantly higher levels of pain (p < 0.05) and reduced endurance in cervical flexor muscles. Our study found a strong correlation between neck pain, muscle endurance, and daily phone usage. Participants using their phones for more than four hours daily reported increased neck pain and decreased muscle endurance. We suggest integrating phone usage duration into neck pain assessments, promoting ergonomic practices, and offering detailed usage guidelines for users.
Citation - WoS: 76
Citation - Scopus: 87
The Associations of Dyadic Coping and Relationship Satisfaction Vary Between and Within Nations: a 35-Nation Study
(Frontiers Media Sa, 2016) Hilpert, Peter; Randall, Ashley K.; Sorokowski, Piotr; Atkins, David C.; Sorokowska, Agnieszka; Ahmadi, Khodabakhsh; Aghraibeh, Ahmad M.; Dural, Seda
Objective: Theories about how couples help each other to cope with stress, such as the systemic transactional model of dyadic coping, suggest that the cultural context in which couples live influences how their coping behavior affects their relationship satisfaction. In contrast to the theoretical assumptions, a recent meta-analysis provides evidence that neither culture, nor gender, influences the association between dyadic coping and relationship satisfaction, at least based on their samples of couples living in North America and West Europe. Thus, it is an open questions whether the theoretical assumptions of cultural influences are false or whether cultural influences on couple behavior just occur in cultures outside of the Western world. Method: In order to examine the cultural influence, using a sample of married individuals N = 7973) from 35 nations, we used multilevel modeling to test whether the positive association between dyadic coping and relationship satisfaction varies across nations and whether gender might moderate the association. Results: Results reveal that the association between dyadic coping and relationship satisfaction varies between nations. In addition, results show that in some nations the association is higher for men and in other nations it is higher for women. Conclusions: Cultural and gender differences across the globe influence how couples' coping behavior affects relationship outcomes. This crucial finding indicates that couple relationship education programs and interventions need to be culturally adapted, as skill trainings such as dyadic coping lead to differential effects on relationship satisfaction based on the culture in which couples live.
Citation - Scopus: 4
The Associations of Dyadic Coping and Relationship Satisfaction Vary Between and Within Nations: a 35-Nation Study (Vol 7, Pg 1106, 2016)
(Frontiers Media Sa, 2016) Hilpert, Peter; Randall, Ashley K.; Sorokowski, Piotr; Atkins, David C.; Sorokowska, Agnieszka; Ahmadi, Khodabakhsh; Yoo, Gyesook; Dural, Seda
Citation - WoS: 64
Citation - Scopus: 76
Automated Patient-Specific Classification of Long-Term Electroencephalography
(Academic Press Inc Elsevier Science, 2014) Kiranyaz, Serkan; İnce, Türker; Zabihi, Morteza; Ince, Dilek
This paper presents a novel systematic approach for patient-specific classification of long-term Electroencephalography (EEG). The goal is to extract the seizure sections with a high accuracy to ease the Neurologist's burden of inspecting such long-term EEG data. We aim to achieve this using the minimum feedback from the Neurologist. To accomplish this, we use the majority of the state-of-the-art features proposed in this domain for evolving a collective network of binary classifiers (CNBC) using multi-dimensional particle swarm optimization (MD PSO). Multiple CNBCs are then used to form a CNBC ensemble (CNBC-E), which aggregates epileptic seizure frames from the classification map of each CNBC in order to maximize the sensitivity rate. Finally, a morphological filter forms the final epileptic segments while filtering out the outliers in the form of classification noise. The proposed system is fully generic, which does not require any a priori information about the patient such as the list of relevant EEG channels. The results of the classification experiments, which are performed over the benchmark CHB-MIT scalp long-term EEG database show that the proposed system can achieve all the aforementioned objectives and exhibits a significantly superior performance compared to several other state-of-the-art methods. Using a limited training dataset that is formed by less than 2 min of seizure and 24 min of non-seizure data on the average taken from the early 25% section of the EEG record of each patient, the proposed system establishes an average sensitivity rate above 89% along with an average specificity rate above 93% over the test set. (C) 2014 Elsevier Inc. All rights reserved.
Basic Science and Pathogenesis
(2024) Noce, G.; Percio, C.D.; Lizio, R.; Lopez, S.; Jakhar, D.; Güntekin, B.; Babiloni, C.
BACKGROUND: Parkinson's disease and Huntington's disease are both neurodegenerative conditions involving the basal ganglia area of the brain. Both conditions can cause symptoms that affect movement. Cognitive decline or dementia can also occur in both. Resting state EEG (rsEEG) rhythms reflect neurophysiological mechanisms and operational functions related to the fluctuation of brain arousal and quiet vigilance in humans. The hypothesis was that rsEEG sources may be more abnormal in Huntington's disease patients in symptomatic stage (S-HD) than patients with dementia due to Parkinson's disease. METHOD: Clinical and rsEEG datasets in 16 PDD, 18 S-HD, and 25 matched cognitively unimpaired (Nold) participants - matched as demography, education, and gender - were taken from an international archive. The eLORETA freeware was used to estimate cortical rsEEG sources at delta, theta, alpha1, alpha2, alpha3, beta1, beta2, and gamma frequency bands. RESULT: Results showed lower amplitude of the posterior alpha activities and higher amplitude of widespread low frequencies bands (i.e., delta and theta) in the PDD and S-HD groups than in the Healthy group. As compared to the PDD group, the S-HD showed greater reductions in the rsEEG alpha 2 rhythms in the frontal and temporal regions (see Figure 1). CONCLUSION: These results suggest that cortical sources of rsEEG rhythms might reflect different abnormalities of the core neurophysiological mechanisms underlying brain arousal in quiet wakefulness and low vigilance in PDD, and S-HD patients. The mentioned rsEEG markers might be clinically useful in the disease staging, monitoring over time, and drug discovery. © 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Browse

Browsing PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection by Scopus Q "Q1"