01. Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed

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Citation - WoS: 1893
Citation - Scopus: 2230
1d Convolutional Neural Networks and Applications: a Survey
(Academic Press Ltd- Elsevier Science Ltd, 2021) Kiranyaz, Serkan; Avcı, Onur; Abdeljaber, Osama; İnce, Türker; Gabbouj, Moncef; Inman, Daniel J.
During the last decade, Convolutional Neural Networks (CNNs) have become the de facto standard for various Computer Vision and Machine Learning operations. CNNs are feed-forward Artificial Neural Networks (ANNs) with alternating convolutional and subsampling layers. Deep 2D CNNs with many hidden layers and millions of parameters have the ability to learn complex objects and patterns providing that they can be trained on a massive size visual database with ground-truth labels. With a proper training, this unique ability makes them the primary tool for various engineering applications for 2D signals such as images and video frames. Yet, this may not be a viable option in numerous applications over 1D signals especially when the training data is scarce or application specific. To address this issue, 1D CNNs have recently been proposed and immediately achieved the state-of-the-art performance levels in several applications such as personalized biomedical data classification and early diagnosis, structural health monitoring, anomaly detection and identification in power electronics and electrical motor fault detection. Another major advantage is that a real-time and low-cost hardware implementation is feasible due to the simple and compact configuration of 1D CNNs that perform only 1D convolutions (scalar multiplications and additions). This paper presents a comprehensive review of the general architecture and principals of 1D CNNs along with their major engineering applications, especially focused on the recent progress in this field. Their state-of-the-art performance is highlighted concluding with their unique properties. The benchmark datasets and the principal 1D CNN software used in those applications are also publicly shared in a dedicated website. While there has not been a paper on the review of 1D CNNs and its applications in the literature, this paper fulfills this gap. (C) 2020 The Author(s). Published by Elsevier Ltd.
Citation - WoS: 6
Citation - Scopus: 7
2db: a Proteomics Database for Storage, Analysis, Presentation, and Retrieval of Information From Mass Spectrometric Experiments
(Biomed Central Ltd, 2008) Allmer, Jens; Kuhlgert, Sebastian; Hippler, Michael
Background: The amount of information stemming from proteomics experiments involving (multi dimensional) separation techniques, mass spectrometric analysis, and computational analysis is ever-increasing. Data from such an experimental workflow needs to be captured, related and analyzed. Biological experiments within this scope produce heterogenic data ranging from pictures of one or two-dimensional protein maps and spectra recorded by tandem mass spectrometry to text-based identifications made by algorithms which analyze these spectra. Additionally, peptide and corresponding protein information needs to be displayed. Results: In order to handle the large amount of data from computational processing of mass spectrometric experiments, automatic import scripts are available and the necessity for manual input to the database has been minimized. Information is in a generic format which abstracts from specific software tools typically used in such an experimental workflow. The software is therefore capable of storing and cross analysing results from many algorithms. A novel feature and a focus of this database is to facilitate protein identification by using peptides identified from mass spectrometry and link this information directly to respective protein maps. Additionally, our application employs spectral counting for quantitative presentation of the data. All information can be linked to hot spots on images to place the results into an experimental context. A summary of identified proteins, containing all relevant information per hot spot, is automatically generated, usually upon either a change in the underlying protein models or due to newly imported identifications. The supporting information for this report can be accessed in multiple ways using the user interface provided by the application. Conclusion: We present a proteomics database which aims to greatly reduce evaluation time of results from mass spectrometric experiments and enhance result quality by allowing consistent data handling. Import functionality, automatic protein detection, and summary creation act together to facilitate data analysis. In addition, supporting information for these findings is readily accessible via the graphical user interface provided. The database schema and the implementation, which can easily be installed on virtually any server, can be downloaded in the form of a compressed file from our project webpage.
The 6-Minute Threshold: Tracking Three-Year Disability and Cognition in Multiple Sclerosis
(Sage Publications Ltd, 2025) Unal, Gozde Deniz; Caliskan, Can; Zengin, Ela; Ozakbas, Serkan
Abernethy Syndrome Presenting With Hepatopulmonary Syndrome, Hematuria and Multiple Fnhs
(Lippincott Williams & Wilkins, 2018) Farajov, R.; Iakobadze, Z.; Yilmaz, C.; Karaca, C.; Kilic, K.; Kul, G.; Tosun, A.
[Abstract Not Available]
Citation - WoS: 23
Citation - Scopus: 31
Activity-Based Costing Approach in the Measurement of Cost of Quality in Smes: a Case Study
(Routledge Journals, Taylor & Francis Ltd, 2013) Ozkan, Serdar; Karaibrahimoglu, Yasemin Zengin
Since the 1950s, a considerable amount of attention has been given on the cost of quality (CoQ) in theory and in practice. Overall, it is argued that a precise measurement of the CoQ requires a well-established accounting system that provides accurate cost information. However, in the literature, it is generally considered that traditional cost accounting methods do not provide accurate cost data for the measurement of quality costs. Therefore, the aim of this study is to explore the role of activity-based costing (ABC) in supporting the measurement of CoQ in small and medium-sized enterprises in order to discuss the results of implementation, its benefits and drawbacks. Overall, it was found that the use of ABC in the CoQ measurement provides the organisation with the means to determine both value-added and non-value-added quality-related activites and to detect improvement opportunities in the production process.
Citation - WoS: 14
Citation - Scopus: 13
Adaptation of Local Businesses To the New Era During the Covid-19 and the Russia-Ukraine War: Case of Cesme
(Routledge Journals, Taylor & Francis Ltd, 2023) Nazli, Murat
Turkey's economic impact has been severe due to the lack of international tourists and the Covid-19 pandemic. Specifically, the tourist destination cesme has suffered economic fluctuations due to decreased international visitors, the Russia-Ukraine war, and insufficient domestic tourists to fill the gap. The study aims to identify deficiencies that help stakeholders manage tourism development amid Covid-19 and the Russia-Ukraine war. The data were collected through semi-structured interviews (n = 34) with local business owners operating for at least 25 years. The study provides insights into the recent tourism development during the pandemic and presents a high level of resilience among local businesses. The business owners perceive the current pandemic and the Russia-Ukraine war situation differently psychologically. Most resilient business owners look for business opportunities by adapting their business models for long-term survival despite the pandemic and the Russia-Ukraine war affecting international tourism.
Citation - WoS: 5
Citation - Scopus: 6
Adaptation of Quality of Life Measure for Limb Lymphedema-Arm in Turkish Women With Breast Cancer-Related Lymphedema
(Lippincott Williams & Wilkins, 2021) Karayurt, Ozgul; Deveci, Zeynep; Eyigor, Sibel; Inbat, Menekse Ozgur
Background Quality-of-life measures are needed for clinicians and researchers to identify quality of women's life with breast cancer-related lymphedema (BCRL). Objective To adapt Quality of Life Measure for Limb Lymphedema-Arm into Turkish (TR) and to test its validity and reliability. Methods This is a methodological and cross-sectional study and was conducted in the lymphedema outpatient clinic of a university hospital. The study included 109 women with BCRL. After linguistic validity of the scale was achieved, confirmatory factor analyses and known group validity were used to test its construct validity. Reliability of the scale was tested with Cronbach's alpha, item-total correlations, and Spearman-Brown coefficient. Results After linguistic validity was achieved, opinions requested from 5 experts specializing in lymphedema showed that item and content validity indexes of the scale were 1. Fit indexes of confirmatory factor analysis were as follows: chi(2)/df = 1.86, root mean square error of approximation = 0.089, standardized root mean square residual = 0.09, and comparative fit index = 0.81. Known group validity analysis showed a significant difference in the mean scores for the subscales of Quality of Life Measure for Limb Lymphedema-Arm-TR, symptom, function, and body image/appearance in terms of lymphedema stages (P < .05). The internal reliability coefficients for the subscales ranged from 0.78 and 0.86. The item-total correlation coefficients ranged between 0.36 and 0.73. Conclusion Quality of Life Measure for Limb Lymphedema-Arm-TR was found to be valid and reliable in the TR population. It could be used in research to evaluate the quality of life in patients with BCRL. Implications for Practice The scale can be used to evaluate effectiveness of nursing interventions directed toward patients developing breast cancer-related lymphedema in clinical settings and studies.
Citation - WoS: 17
Citation - Scopus: 20
Adaptive Neural Network-Based Saturated Control of Robotic Exoskeletons
(Springer, 2018) Asl, Hamed Jabbari; Narikiyo, Tatsuo; Kawanishi, Michihiro
In this paper, novel adaptive neural network (NN) controllers with input saturation are presented for n-link robotic exoskeletons. The controllers consist of a state feedback controller and an output feedback controller. Through utilizing auxiliary dynamics, the controllers provide a new framework for input saturated control of these robotic systems which can feature the global stability for state feedback control. To compensate for the unknown dynamics of the system, adaptive schemes based on NNs are exploited. Furthermore, adaptive robust terms are utilized to deal with unknown external disturbances. Stability studies show that the closed-loop system is globally uniformly ultimately bounded (UUB) with the state feedback controller, where the global property of the NN-based controller is achieved exploiting a smooth switching function and a robust control term. Also, the system is semi-globally UUB with the output feedback controller. Effectiveness of the controllers is validated by simulations and experimental tests.
Citation - WoS: 45
Citation - Scopus: 56
An Adaptive Tabu Search Approach for Buffer Allocation Problem in Unreliable Non-Homogenous Production Lines
(Pergamon-Elsevier Science Ltd, 2012) Demir, Leyla; Tunali, Semra; Eliiyi Türsel, Deniz
The buffer allocation problem, i.e. how much buffer storage to allow and where to place it within the line, is an important research issue in designing production lines. In this study, a novel adaptive tabu search approach is proposed for solving buffer allocation problem in unreliable and non-homogeneous production lines. The objective is to maximize the throughput of the line, which is constrained by the capacity of each buffer space and also the total buffer capacity to allocate to these spaces. Besides proposing a new strategy to tune the parameters of tabu search adaptively during the search, an experimental study is carried out to select an intelligent initial solution scheme among three alternatives so as to decrease the search effort to obtain the best solutions. The performance of the proposed approach is evaluated by computational tests and very promising results are obtained. (C) 2011 Elsevier Ltd. All rights reserved.
Citation - WoS: 2
Citation - Scopus: 2
Adjuvant Action of Needle-Shaped Bc Microfibrils
(Springer, 2023) Sür, Özge; Gül, Aytul; Hames, Elif Esin
Bacterial cellulose (BC) is an unbranched biopolymer produced by microorganisms and composed of glucopyranose units linked by beta-1,4 bonds. This study investigates the adjuvant action of needle-shaped BC microfibrils (BCmFs) in vitro using bovine serum albumin (BSA) as a model antigen. BC produced by the static culture of Komagataibacter xylinus was then microparticled (1-5 mu m) by acid hydrolysis and characterized using Dynamic Light Scattering and Scanning Electron Microscopy. Subsequently, Attenuated Total Reflectance-Fourier-Transform Infrared Spectroscopy, cytotoxicity, TNF-alpha (tumour necrosis factor-alpha) and IL-6 (interleukin-6) cytokine secretion, and cellular uptake of the BCmFs-BSA conjugate on the human monocyte cell line (U937) differentiated into macrophages were performed. The microfibrils were determined to be 1-5 mu m in size, needle-shaped, with a zeta potential of - 32 mV. Their conjugation with the model antigen, BSA, was demonstrated by FTIR analysis. In the cytotoxicity assay, BCmFs-BSA in macrophage cells showed high viability (over 70%). Although the highest TNF-alpha cytokine level (113 pg/ml) was obtained with BCmFs-BSA (Bovine serum albumin) conjugate (500 mu g/ml) and was statistically significant (p = 0.0001) compared to the positive control group (BSA-aluminium hydroxide), IL-6 cytokine levels were not statistically different from those in the control group as desired. It has been shown in macrophage-differentiated U937 cells that microbially synthesized BC in the form of needle-shaped microfibrils (BCmFs) has a high cellular uptake capacity and increases the immunogenicity of the antigen. These results demonstrate for the first time that BCmFs have the potential to serve as a vaccine adjuvant.
Citation - WoS: 4
Citation - Scopus: 5
Advanced Nurse-Patient Communication System
(Springer, 2012) Unluturk, Mehmet S.
Effective communication is the most important part of any healthcare organization. For many years, hospital nurse call solutions had been stand-alone systems with occasional integration to pocket paging for outputting patient call alerts to mobile staff. In the late 1990's, technology enabled in-building wireless phones to supplement or replace paging systems as a means of not only sending alerts, but also enabling voice communication between mobile staff and patients. Today's nurse call market requires integration of additional information from location and ADT (admit, discharge, transfer) systems into what have traditionally been nurse call applications. This system information is required not only at the nursing station, pagers, and phones, but also at PC's placed on each patient care floor in hallways, nurse stations, and offices, and at areas away from the patients, including administrator and clinical engineering offices. It is crucial that nurses have the latest patient information in their hand wherever they go in the hospital. In this paper, MatchMaker.NET has been developed to integrate all these technologies into the hospital's LAN to improve nurse-patient communication.
Advanced Turkish
(Equinox Publishing Ltd, 2011) Sahin, Mehmet
[Abstract Not Available]
Citation - WoS: 10
Citation - Scopus: 9
Advancements in Platinum Chemotherapy for Metastatic Castration-Resistant Prostate Cancer: Insights and Perspectives
(ELSEVIER SCI LTD, 2024) Akkuş, Erman; Arslan, Çağatay; Ürün, Yüksel
Despite improvements in survival, metastatic castration-resistant prostate cancer (mCRPC) remains a significant clinical challenge. While taxanes, new hormonal agents, radiopharmaceuticals, and PARP inhibitors offer valuable treatment options, this review explores the potential of platinum chemotherapies (carboplatin, cisplatin, and oxaliplatin) as alternative choices. Existing research demonstrates promising preliminary results for platinum-based therapies in mCRPC showing PSA response rates (7.7-95 %) and improved overall survival (8-26.6 months). However, chemotherapy-related cytopenias are a frequent side effect. Further research is underway to evaluate the efficacy of platinum regimens against specific mCRPC histopathological variants, particularly aggressive subtypes where the carboplatin and cabazitaxel combination is already recommended. The unique DNA-targeting action of platinum therapy holds promise for patients with deficient DNA repair (dDDR), especially those with BRCA mutations. This potential is supported by both preclinical and ongoing clinical research. Given the limited success of immunotherapy in mCRPC, researchers are exploring the potential for platinum therapies to enhance its efficacy. Additionally, trials are investigating the synergy of combining platinum therapy with both immunotherapy and PARP inhibitors. Further exploration into the effectiveness of platinum therapies in specific mCRPC subpopulations, particularly those with dDDR, is crucial for optimizing their future use. In conclusion, this review highlights the promising potential of platinum-based chemotherapy as a valuable treatment option for mCRPC. While current evidence is encouraging, ongoing research is essential to further optimize its efficacy, identify optimal combinations with other therapies, and better understand its impact on specific mCRPC subpopulations.
Citation - WoS: 16
Citation - Scopus: 23
Advancing a Participatory Approach for Youth Risk Behavior: Foundations, Distinctions, and Research Directions
(Elsevier Science Inc, 2013) Mason, Marlys J.; Tanner, John F.; Piacentini, Maria; Freeman, Dan; Anastasia, Trena; Batat, Wided; Boland, Wendy
Researchers of youth risk behavior frequently assume that behavior is volitional; the choice is to either engage in a risky behavior or a safe alternative. Yet, many factors may constrain life choices, not the least of which is how individuals view risk. The study here examines youth risk research to identify general knowledge gaps and shortcomings that may be limiting the positive impact of research-based efforts to promote youth well-being. The study proposes alternative approaches that address these gaps and shortcomings in particular with recognition of the social contexts of both risks and the programs designed to address those risks. A distinctive foundation for a participatory approach to understanding youth risk behavior is then developed. Published by Elsevier Inc.
Citation - WoS: 24
Citation - Scopus: 25
Affective Reactions To One's Whole Life: Preliminary Development and Validation of the Ontological Well-Being Scale
(Springer, 2013) Simsek, Omer Faruk; Kocayoruk, Ercan
In line with the perspective provided by the intentional paradigm which claims that the measures of subjective well-being (SWB), whether cognitive or affective, should refer to life itself, the Ontological Well-Being Scale (OWBS) has been operationalized. The research reported herein was aimed at developing and validating this psychometric tool in the assessment of individuals' affective evaluations of their life within a three-time perspective. Five studies were conducted to confirm the factor structure of the OWBS and to assess its construct validity. Four factors were derived and validated, which were shown to relate to mental health indicators and personality in expected ways. It was found that this new construct, in contrast with the current measures, did not tap into the personality factors of extraversion and neuroticism. Incremental validity results showed that the OWBS explained additional variance in mental health indicators already captured by the current measures of SWB.
Age Matters: Distinct Disability Patterns in Multiple Sclerosis Patients Initiating Therapy After the Age of 50
(Sage Publications Ltd, 2025) Zengin, Ela; Caliskan, Can; Simsek, Yasemin; Unal, Gozde Deniz; Ozakbas, Serkan
Age-Related Differences in E-Health Literacy in People with Multiple Sclerosis
(Sage Publications Ltd, 2025) Yavas, Ipek; Karakas, Hilal; Celik, Rabia Gokcen Gozubatik; Cansiz, Melek; Ertekin, Ozge; Kahraman, Turhan
Citation - WoS: 11
Citation - Scopus: 17
An Aggregated Fuzzy Naive Bayes Data Classifier
(Elsevier Science Bv, 2015) Tütüncü, Gözde Yazgı; Kayaalp, Necla
In this study, an Aggregated. Fuzzy Naive Bayes Classifier is proposed for decision-making problems where both linguistic and numerical information are available. In the solution process of such problems, all attributes are considered as fuzzy numbers and a procedure based on 2-tuple fuzzy linguistic representation model is generated for combining them. This procedure and subsequent Fuzzy Naive Bayes classification are performed based on arithmetic operations defined by Chen's function principle. The proposed method was demonstrated on 2 well-known examples from the literature in which both numerical and linguistic attributes were considered. The results show that the proposed Aggregated Fuzzy Naive Bayes Classifier is notably efficient in decision-making where the attributes are in more realistic forms. (C) 2015 Elsevier B.V. All rights reserved.
Citation - WoS: 17
Citation - Scopus: 16
Agility and Resource Dependency in Ramp-Up Process of Humanitarian Organizations
(Emerald Group Publishing Ltd, 2019) Qing, Lu; Wu, Jie; Goh, Mark; De Souza, Robert
Purpose The ramp-up in humanitarian logistics operations is a stage when the demand surges, often at the start of an emergency. In response, agility is a key strategy used by the humanitarian organizations (HOs). However, the HOs are constrained by their existing resources and have to respond in the ramp-up process under their resource dependency. The purpose of this paper is to develop a framework on agility-building strategies used by HOs for the ramp-up. Design/methodology/approach This study applies both the dynamic capabilities perspective and resource dependence theory to humanitarian relief operations, and develops four testable propositions to explore the agility-building strategies of the HOs for the ramp-up process. A multiple-case study is conducted on six international HOs operating in Indonesia to verify them, in addition to an extensive literature search. Findings The case study shows that the human resource management, pre-positioning, standardization and supplier management of the HOs are all related to their resources and environment in the ramp-up process. The authors highlight the practical differences between the few super large, resource rich and centralized HOs with the second-tier HOs. Research limitations/implications - Given the small sample size and single country as the site of study, some findings may not be applicable to the other HOs or in other regions. Practical implications - The propositions could be applicable to other HOs operating under similar environments, and potentially to the commercial enterprises operating in a highly volatile environment with severe resource scarcity. Originality/value This study provides new insights into ramp-up operations and into how HOs build their agility and reduce their resource dependencies. Theoretically, the paper applies two established theories in the strategic management literature to a new field.
Citation - WoS: 2
Citation - Scopus: 2
Aging Attenuated Theta Response During Multistable Perception
(Wiley, 2023) Küçük, Kurtulus Mert; Mathes, Birgit; Schmiedt-Fehr, Christina; Başar Eroğlu, Canan
Multistable stimuli are physically unchanging, but elicit spontaneous perceptual reversals between multiple internally generated perceptual alternatives. Perceptual reversal rates seem to decrease in older adults; however, there is no literature on the electrophysiological correlates of this performance decrease. Here, we aimed to identify age-related changes in theta activity that relate to decreased reversal rates of older adults. Electroencephalography (EEG) of young (n = 15) and older adults (n = 15) was recorded during presentation of stroboscopic alternative motion (SAM) and a control stimulus. Time-frequency amplitudes were extracted in 4-8 Hz via Morlet wavelet convolution. Older adults had lower SAM reversals as well as decreased accuracy, increased reaction time (RT) and increased RT variability in the control task. In older adults, reversal-related frontal theta response was diminished, yet parietal theta was intact. In the parietal area, the relationship between theta response and reversal rates was robust, but in the frontal area, was dependent on age-related variance. Result indicated that, in older adults, top-down facilitation of perceptual reversals was impaired. This appears to result in a predominantly bottom-up resolution of perceptual multistability. Age-related degradation of sensory areas in this bottom-up-driven resolution process might have slowed reversals. This study presents the first electrophysiological correlates of age-related impairment in multistable perceptual integration.

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