TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Long-Stem Prosthesis for Intertrochanteric and Femoral Neck Fractures in the Elderly: Retrospective Comparison of Short-Term Clinical Outcomes(Galenos, 2021-04-09) Çekok, Kübra; Biçen, Çağdaş; Akdemir, Mehmet; Türken, Mehmet Aykut; Çekok, Fatma Kubra; Bıcen, Ahmet CagdasObjective: Hip fracture treatment in elderly patients remains challenging. This study aimed to evaluate short-term clinical results of long-stem cementless arthroplasty in elderly patients with femoral neck and intertrochanteric fractures. Materials and Methods: We collected data of patients we treated with long-stem cementless arthroplasty between January 2011 and December 2019 due to hip fractures. This study included 48 patients (>= 65 years of age) with femoral neck and intertrochanteric fractures. The patients underwent either bipolar or total hip arthroplasty. A 2-year follow-up was conducted in all the patients. Outcomes were evaluated with the Harris hip score (HHS), Koval categories, complications and hip and mid-thigh pain. We compared clinical results of patients with femoral neck fractures and those with intertrochanteric fractures. Results: The mean follow-up period was 57 (34-92) months. Sixteen patients had femoral neck fractures and 32 had intertrochanteric fractures. No difference in demographic characteristics and comorbidities was noted between groups. The mean preoperative Barthel index of activities of daily living score was 79. At the last follow-up, the mean HHS of the control group was 77 and the mean Koval categories score was 3. Revision surgeries were conducted in two patients due to dislocation. Infection was observed in one patient and was treated by debridement and anti-biotherapy. Implant loosening and periprosthetic fractures were not noted. Conclusion: With fair outcomes, long-stem cementless arthroplasty is a potential treatment for hip fractures in elderly patients. A longer follow-up to evaluate the efficacy of these prostheses is warranted.Article A Preliminary Study of Possible Fibrotic Role of Meprin Metalloproteases in Scleroderma Patients(Turkish League Against Rheumatism (TLAR), 2021-12-31) Avşar, Aydan Köken; Merih Birlik, A.; Koçak, Ayşe; Harmancı, Duygu; Akdoğan, Gül; Birlik, Merih; Birlik, A. Merih; Güner, Gül AkdoganObjectives: This study aims to investigate the possible fibrotic role of meprin metalloproteases and possible fibrotic effects of activator protein-1 (AP-1) in scleroderma patients. Patients and methods: Between April 2018 and April 2019, a total of 85 scleroderma patients (9 males, 76 females; mean age: 54.9 +/- 12.1 years; range, 22 to 80 years) who met the 2013 American College of Rheumatology/European League Against Rheumatism criteria and 80 healthy control individuals (10 males, 70 females; mean age 42.9 +/- 10.2 years; range, 19 to 65 years) were included. Patients' data and blood samples were collected. Messenger ribonucleic acid expressions of interleukin (IL)-6, AP-1 subunits, and tumor necrosis factor-alpha (TNF-alpha) were analyzed by quantitative real-time polymerase chain reaction. Serum meprin alpha and beta protein levels were analyzed using the enzyme-linked immunosorbent assay. Results: Meprin alpha and meprin beta protein levels increased in scleroderma patients. The AP-1 subunits (c-Fos, c-Jun), IL-6, and TNF-alpha increased in scleroderma patients, compared to controls. Conclusion: Our results provide evidence showing that increased meprins levels may be related to AP-1 levels and increased meprins levels may responsible for increased inflammatory TNF-alpha and IL-6 levels. All these data suggest meprins as promising therapeutic targets to restore the balance between inflammation and extracellular matrix deposition in scleroderma.Article The Clinical Features of Arthritis in Behçet’s Disease(2025-03-21) Kehribar, Demet Yalcin; Ozgen, Metin; Kırcı, Cem Kıvanç; Kırcı, ÖzlemAim: This study aims to explore the clinical, laboratory, and systemic differences between Behçet’s disease (BD) patients with arthritis and those without, focusing on how arthritis influences disease progression and treatment strategies. Material and Methods: A retrospective, observational study was conducted on 881 patients diagnosed with BD according to the International Study Group criteria. Patients were categorized into two groups: those with arthritis (n=233) and those without (n=648). Clinical findings, laboratory markers [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR)], and systemic manifestations, including neurological and vascular complications, were compared between the groups. Statistical analyses were performed to identify significant differences. Results: Patients with arthritis exhibited higher systemic inflammation, as evidenced by elevated ESR (37.6±23.9 vs. 31.1±23.9, p=0.000) and CRP (25.9±32.2 vs. 18.6±34.6, p=0.006) at baseline. Family history of BD was more prevalent in the arthritis group (15% vs. 10%, p=0.041). Neurological involvement was significantly higher in the non-arthritis group (11% vs. 4%, p=0.002), as were vascular complications, including: pulmonary artery aneurysms (2%, p=0.043) in the non-arthritis group and arterial thrombosis (5% vs. 1%, p=0.025). Patients with arthritis were more likely to receive corticosteroid therapy (36% vs. 21%, p=0.019), while pulse corticosteroid use was higher in the non-arthritis group (9% vs. 4%, p=0.008). Conclusion: BD patients with arthritis demonstrate heightened systemic inflammation, a stronger genetic predisposition, and greater reliance on corticosteroids. In contrast, those without arthritis have higher rates of severe systemic complications, including neurological and vascular involvement. These findings emphasize the importance of individualized management strategies tailored to the presence or absence of arthritis, addressing the diverse clinical spectrum of BD.Article The Evaluation of Health Status of Familial Mediterranean Fever Patients with Homozygous M694V Mutation(2025-09-02) Kehribar, Demet Yalcin; Ozgen, Metin; Baraz, Lale Saka; Çakar, AyşegülAim: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder characterized by recurrent episodes of fever, serositis, and systemic inflammation. The M694V mutation in the MEFV gene is associated with a more severe disease phenotype, including early onset, frequent attacks, and an increased risk of amyloidosis. This study aimed to evaluate the clinical features, comorbidities, and treatment outcomes of FMF patients homozygous for the M694V mutation. Material and Methods: A retrospective analysis was conducted on 183 FMF patients homozygous for the M694V mutation, diagnosed and followed at our hospital between 2014 and 2022. Data on demographics, clinical characteristics, laboratory findings, and treatment modalities were collected. Results: The most common symptoms were abdominal pain (88%), joint pain (78%), and arthritis (46%). Proteinuria and amyloidosis were detected in 22.4% and 7.1% of patients, respectively. The average age of symptom onset was 14.1 years, with a mean annual attack frequency of 2.75. Comorbidities were present in 24% of patients, including spondyloarthritis and inflammatory bowel disease. Colchicine was the mainstay treatment (94.5%), while 21.8% required IL-1 inhibitors. Eight patients (4.4%) died during follow-up, five due to amyloidosis-related complications. Conclusion: M694V homozygous FMF patients exhibit a severe disease presentation associated with this variant with frequent attacks, high amyloidosis risk, and significant comorbidities. While colchicine remains essential, biologics are increasingly used for colchicine-resistant cases. Early diagnosis, individualized treatment, and regular monitoring are crucial to improving patient outcomes.Article Ankilozan Spondilitli Bireylerde Hangi Solunum Eğitimi Daha Etkilidir: 360-Derece Ekspanse Diyafram Egzersizleri Mi, Standart Diyafram Egzersizleri Mi? Randomize Kontrollü Çalışma(2025-09-30) Urak, Özkan; Sari, Ismail; Gurpinar, Baris; Yeşilyurt, Seda YakıtAmaç: Solunum komplikasyonları genellikle asemptomatik olsa da Ankilozan Spondilit (AS) hastalarında önemli bir morbidite ve mortalite nedenidir. Egzersizin AS yönetimindeki kanıtlanmış faydalarına rağmen, geleneksel diyafram nefesi ile göğüs kafesinin tamamını hedefleyen çok boyutlu, yenilikçi yaklaşımların karşılaştırıldığı sınırlı sayıda çalışma bulunmaktadır. Bu çalışma, standart diyafram nefesi ile sensör destekli 360 derece ekspanse diyafram nefesi egzersizlerinin solunum fonksiyonu, hastalık aktivitesi ve fiziksel kapasite üzerindeki etkilerini değerlendirerek bu boşluğu doldurmayı amaçlamıştır. Gereç ve Yöntem: AS tanısı almış 50 birey, standart diyafram nefesi grubu (DG) veya 360 derece ekspanse diyafram nefesi grubu (360DG) olmak üzere rastgele iki gruba ayrılmıştır. Her iki gruba da altı hafta boyunca haftada iki kez denetimli egzersiz uygulanmıştır. Değerlendirilen sonuçlar arasında solunum fonksiyon testleri, maksimal inspiratuvar ve ekspiratuvar basınçlar (MIP/MEP) ve AS’ye özgü indeksler yer almıştır. Bulgular: Her iki grupta da işlevsel indeksler ve solunum parametrelerinde anlamlı iyileşmeler gözlemlenmiş, ancak gruplar arası farklar istatistiksel olarak anlamlı bulunmamıştır (p>0,05). Özellikle, DG grubunda FEV1/FVC oranında anlamlı bir artış (p = 0,017), 360DG grubunda ise FVC değerinde anlamlı bir artış (p = 0,007) saptanmıştır. Solunum kas gücü (MIP ve MEP) her iki grupta da anlamlı şekilde artmıştır (p<0,05). Sonuç: Bu randomize kontrollü çalışma, AS’de 360 derece ekspanse diyafram nefesi egzersizlerini değerlendiren ilk çalışmalardan biridir. Bulgular hem standart hem de sensör destekli nefes egzersizlerinin solunum ve fonksiyonel sonuçları iyileştirmede güvenli ve etkili olduğunu göstermektedir. Bu sonuçlar, fizyoterapistler ve klinisyenler için kişiye özel solunum eğitiminin AS rehabilitasyon programlarına entegre edilmesinin klinik önemini vurgulamakta ve hasta bakımını geliştirmek için esnek, kanıta dayalı stratejiler sunmaktadır.Article Virtual Drug Screening Study to Discover Novel ERAP1 Allosteric Site Inhibitors for the Treatment of Ankylosing Spondylitis (AS)(Marmara Univ, Fac Pharmacy, 2025-04-08) Portakal, Hüseyin Saygın; Alp, Beste; Akyol, MertcanEndoplasmic reticulum aminopeptidase 1 (ERAP1) is one of the key molecules in the antigen presentation process. To date, associations of ERAP1 with Ankylosing Spondylitis (AS) have been revealed with strong data. As such, to target the allosteric site of ERAP1 exhibits a therapeutic potential in the treatment of AS. In this paper, 9,800 ligands from “FDA-Approved Drugs'', “World-not-FDA Approved Drugs'', and “Drugs in Clinical Trials'' datasets of ZINC15 database were screened to the allosteric site of ERAP1. The best scored drugs are filtered with ADME analysis, the toxicity and bioactivity profiles of the discovered drugs and the known inhibitors were investigated. Results revealed that ZINC000100052688 (Ventavis), ZINC000004217466, and ZINC000024760115 (Dactolicib) follow the Lipinski’s rule of five and have -10.0 kcal/mole, -9.8 kcal/mole, and -9.7 kcal/mole binding affinities to allosteric site of ERAP1, respectively. Furthermore, ZINC000004217466 is the most promising since it has high protease and enzyme inhibitory activity with no toxicity. Due to that to date, only few chemical ligands recognizing ERAP1 regulatory site have been synthesized, to reveal possible repurposable drugs is quite promising, and ZINC000004217466 is the best candidate among 9,800 drugs since it has rather binding affinity, proper chemical properties, no toxicity, and high bioactivity in the inhibition of ERAP1 regulatory site.Article Citation - WoS: 1Citation - Scopus: 125-Hydroxyvitamin Levels in Sjögren’s Syndrome: Is It the Right Time to Dismiss the Case or Not(Walter de Gruyter GmbH, 2024-09-23) Sımsır, Ilgın Yıldırım; Tanigor, Goksel; Karabulut, Gonca; Barutcuoglu, Burcu; Yılmaz, ZevcetObjectives: This study aimed to investigate whether patients with primary Sjögren syndrome (SjS) have different levels of 25 OH-D3 (vitamin D) when compared to healthy populations and whether differences in 25 OH-D3 correlated with disease activity or markers. Methods: Eighty-eight female patients with SjS and 3,338 age-matched healthy female controls were included in this study. 25 OH-D3 levels were compared with healthy controls. Then the patients were stratified according to their 25 OH-D3 levels, either insufficient/deficient or normal (<50 nmol/L or ≥50 nmol/L). The disease activity was evaluated using The EULAR SjS disease activity index (ESSDAI) and its components. Correlation analyses were also performed for a possible correlation with disease characteristics and markers of activity. Results: No differences in 25 OH-D3 levels were found between SjS and healthy populations (p>0.05). No correla- tions were found between patient characteristics or labo- ratory values (p>0.05). Conclusions: This study did not find a link between disease characteristics and disease activity and 25 OH-D3 levels. Prospective studies with more patients should be conducted to reach a conclusion.Article Citation - WoS: 1Citation - Scopus: 1YouTube as a Source of Information on Inflammatory Muscle Diseases: Can It Provide Valid and Reliable Information for Patients as Well as Healthcare Professionals?(Galenos Publishing House, 2024-08-07) Tanıgör, Göksel; Karabulut, GoncaObjective: The increasing use of the internet has resulted in its gaining a more active role in both patient and professional education, including the YouTube platform, a popular platform for sharing and watching videos. This study aimed to evaluate the quality, usefulness, and reliability of videos on inflammatory muscle diseases on YouTube, as well as their determinants for both patient and healthcare professional education. Materials and Methods: The keywords “Inflammatory muscle disease”, “Idiopathic inflammatory myositis”, “Inflammatory muscle disease treatment”, “Inflammatory myositis treatment”, “Dermatomyositis” and “Polymyositis” were searched on the site on April 22nd, 2022. According to the Global Quality scale, three categories (high quality, middle quality, and low quality) were created based on the educational value of YouTube videos. The reliability of the information was assessed using the DISCERN tool. The video parameters were compared between the quality groups to reveal the determinants of the quality. Results: Seventy-five videos of patients and 116 videos of healthcare professionals were included in the video after exclusion. The numbers of high, intermediate and low-quality videos were 27 (36%), 27 (36%), and 21 (28%) for videos for patients, and 20 (17.2%), 60 (51.8%), and 36 (31%), respectively. Only the number of likes was found to be a determinant of video quality for healthcare professionals (p<0.05), and none of the other determinants were found to predict the quality for both groups (p>0.05). Conclusion: YouTube is an open platform for information, and it includes various educational videos of various quality. Experts, such as physicians, should be encouraged to provide more content to help both patients and healthcare professionals obtain better quality information. © 2025 Elsevier B.V., All rights reserved.Article Unresolved Pain in a Middle-Aged Woman: an Integrated Family Medicine Approach(Cukurova Univ, FAC Medicine, 2023-09-30) Küçükerdem, Halime Seda; Aygün, Olgu; Gökdemir, Özden47 years old woman had applied to the outpatient clinic as she was suspicious because of COVID-19. The patient has non-specific symptoms such as fever, pain, and anosmia. The family physician has prescribed Enfluvir, vitamin D, etol-fort tb . After the medication, she has come to the clinic again because of the not finished pain. The family physician that the first one consulted has ordered Magnetic Resonance Imagining for the sacroiliac region as the patient told that the pain when she was sitting for at least two and half years and nowadays her pain was more although she was taking her painkillers. According to the non-contrast, MRI of the sacroiliac joint: “ joint surfaces exhibit irregularity and narrowing. In the posterior, more prominent articular surfaces on the right in the fat-suppressed axial and coronary sequences, there is focal bone marrow edema and sacroiliitis activation. The right adnexa within the sections showed an 8 cm cystic appearance. MRI and USG of the lower abdomen are advised.”. The lab and also with IV contrast, MRI of the pelvis, and ultrasonography were planned with the rheumatology and gynecology consultations.Article Citation - WoS: 2Matrix Metalloproteinase-2 and -3 Levels in Patients With Behçet's Disease and Implication for the Presence of Vascular Aneurysm or Neurologic Involvement(AVES, 2023-08-24) Erten, Pınar Talu; Keser, Gökhan; Durusoy, Raika; Kocaer, Sinem Burcu; Aksu, KenanBackground: Behçet's disease is a systemic vasculitis affecting both arteries and veins, as well as causing recurrent inflammatory multiorgan disease. Vascular involvement is associated with increased mortality and morbidity. Matrix metalloproteinases are released at sites of inflammation and degrade various components of the extracellular matrix. Increased levels of metalloproteinase-9 and metalloproteinase- 2 have been previously reported in Behçet's disease. Methods: In this cross-sectional study, metalloproteinase-2 and metalloproteinase-3 serum levels were investigated in 103 patients with Behçet's disease and 69 healthy controls, using Invitrogen immunoassay human metalloproteinase-2 and metalloproteinase-3 ELISA kits. Results: Serum metalloproteinase-2 and metalloproteinase-3 levels were significantly higher in the Behçet's disease group compared to healthy controls. Besides, serum metalloproteinase-3 levels were significantly higher in subgroups of Behçet's disease with aneurysmal vascular involvement and with neurological involvement. However, metalloproteinase-2 and metalloproteinase-3 serum levels did not show a positive correlation with disease activity. Conclusion: Metalloproteinase-2 and -3 may contribute to the complex pathogenesis of Behçet's disease. More importantly, the detection of very high serum levels of metalloproteinase-3 may predict the formation of an aneurysm, or possibly the presence of neurological involvement in Behçet's disease and may lead the clinician to make an earlier diagnosis of these complications in young male patients with high risk.