TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Citation - WoS: 1Increased Serum Levels of Nmda Receptor Antibodies in Female Patients With Bipolar Disorder(Klinik Psikiyatri Dergisi, 2018) Ceylan, Deniz; Akan, Pinar; Doyuran, Kerim; Can, Gunes; Ersen, Ayca; Misir, Emre; Ozerdem, Aysegul; Acar, Can M. Güneş; Özalp, Deniz Ceylan TufanObjective: Glutamatergic/GABAergic imbalance due to autoimmune antibodies targeting N-methyl-D-aspartate receptors (NMDA-R) is considered to be one of the shared pathways between bipolar disorder (BD) and autoimmune diseases. Evidence shows female vulnerability to autoimmune disorders, and suggests a sex-specific approach in autoimmunity research in BD. We aimed to assess serum concentrations of NMDA-R antibodies and density of NMDA and GABA receptors on platelets in euthymic patients with BD in comparison to healthy individuals; and to determine the impact of sex on serum concentrations of NMDA-R antibodies and the density of NMDA and GABA receptors on platelets. Method: NMDA antibody IgG were detected in serum samples of 27 DSM IV euthymic patients with bipolar disorder (16 females, 11 males) and 33 healthy individuals (17 females, 16 males), using ELISA method. The densities of NMDA and GABA receptors on platelets were investigated using immunocytochemical methods. Results: Patients with BD presented higher serum levels of NMDA-R antibodies in comparison to healthy individuals (p < 0.001). The densities of NMDA and GABA receptor on platelets were similar in both groups. The NMDA-R antibody levels were influenced by both diagnosis and sex (F = 5.813, df = 1, p = 0.020). Tserum lithium levels showed a significant linear association with the serum NMDA-R antibody levels even adjusting for age, sex, body mass index (F = -56.26, t = -2.52, p = 0.015, CI: -101.12/-11.40). Discussion: Our findings support a potential role of NMDA-R antibodies in the underlying pathophysiology of BD, particularly for females.Article Citation - Scopus: 2Behavioral Immune System and Trypophobia(Klinik Psikiyatri Dergisi, 2022) Ozturk, Suleyman; Ceylan, Deniz; Demir, Ayse Banu; Kazdagli, Hasan; Erdeniz, BurakPathogens, which are the source of infectious diseases, have imposed a strong selection pressure on human evo-lution as one of the most important causes of human death during the natural selection process. As a result of this, it is assumed that a variety of adaptations have evolved against infection threats and one of these adap-tations is the physiological immune system. However, activation of the physiological immune system can be quite costly for organisms in some cases, and therefore it has been recently proposed in evolutionary psychology that an adaptive system called behavioral immune sys-tem may have evolved in association with the proactive functional processes against pathogen threats. Furthermore, it was hypothesized that a number of psy-chopathologies might develop as a result of maladaptive processes affecting the functionality of this system, and one of these psychopathologies might be trypophobia. Trypophobia refers to a psychological disorder in which individuals experience aversion and disgust at excessive levels toward clusters of small objects such as holes and bumps. Following this, the current review was estab-lished within the framework of three distinct goals. Firstly, this review aimed to discuss the evolutionary basis and mechanisms of the behavioral immune system. Secondly, the review aimed to discuss the characteristic features and the etiological explanations of trypophobia. Finally, the review aimed to discuss how potential changes in the behavioral immune system might lead to the development of trypophobia.