TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Investigation of Neuraminidase 1 Gene Association in Henoch-Schönlein Purpura (hsp) With Renal Involvement(Pamukkale University, 2022-07-01) Yılmaz, N.B.; Ertan, P.; Yüksel, S.; Neşe, N.; Dinç Horasan, Gönül; Berdeli, A.H.; Horasan, Gönül Dinç; Bahçeci, Nezihe BilgePurpose: HSP is a common small vessel vasculitis. It is the most common cause of non-thrombocytopenic purpura in childhood. The role of genes in etiopathogenesis of the disease, which has not yet been clearly elucidated, is being emphasized. Many genes called sialidases are being studied and is thought that the NEU1 gene may be particularly important in the etiopathogenesis of HSP. The aim of this study is to investigate the role of the NEU1 gene in the etiopathogenesis of HSP and its relation to renal involvement. Materials and methods: Fifty patients followed in the Celal Bayar University Hafsa Sultan Hospital Pediatric Nephrology Department, with the diagnosis of HSP renal involvement were included into the study. For the control group, age and gender matched 50 cases were accepted among the outpatients admitted to Pediatric Department without any chronic diseases. NEU1 gene mutation analysis was performed in blood samples of both patient and control groups by using the Sanger DNA sequencing method. Results: NEU1 genetic mutation was not detected in any HSP patient with renal involvement and control group. Conclusion: In our study, the NEU 1 gene was not found to be associated with HSP nephritis. No changes were detected in the investigated regions of the NEU1 gene. © 2022, Pamukkale University. All rights reserved.Article Citation - WoS: 5Citation - Scopus: 5The Validity and Reliability of the Turkish Version of the Physical Activity Scale for Individuals With Physical Disabilities (pasipd)(Tubitak Scientific & Technical Research Council Turkey, 2019) Ulas, Kardem; Topuz, Semra; Dinc Horasan, Gonul; Horasan, Gönül DinçBackground/aim: The aim of this study is to assess the validity and reliability of Turkish translation of the Physical Activity Scale for Individuals with Physical Disabilities (PASIPD) in a disabled Turkish population. Materials and methods: Following the translation protocol of the PASIPD, the Turkish version of the PASIPD, Short Form-36, and International Physical Activity Questionnaire were administered to 198 developmentally and physically disabled individuals. Results: The Turkish version of the PASIPD was found to be reliable. The domains of the Turkish version of the PASIPD were also found to be valid. Pour factors were obtained from the questionnaire. The ICC was 1.0 since all the respondents reported the same answers in the test and retest. The Cronbach alpha for the PASIPD was 0.60. Conclusion: The Turkish version of the PASIPD survey is valid and reliable for developmentally and physically disabled Turkish individuals and professionals can use it to assess physical activity level.