TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4

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Author: search.filters.author.Kazdagli, HasanCOAR Access Rights: search.filters.coarAccessRights.open access

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  • Article
    Citation - WoS: 9
    Citation - Scopus: 9
    Classical Heart Rate Variability and Non-Linear Heart Rate Analysis in Mice Under Na-Pentobarbital and Ketamine/Xylazine Anesthesia
    (Tubitak Scientific & Technical Research Council Turkey, 2022-01-01) Kazdagli, Hasan; Ozel, Hasan Fehmi; Ozbek, Mustafa; Alpay, Suheda; Alenbey, Muruvvet
    Background/aim: Anesthetics are often used in animal experiments to achieve immobilization and relieve pain. However, many anesthetics can alter the dynamics of cardiovascular systems. We aimed to compare the effects of two frequently used anesthetics agents on heart rate variability (HRV) parameters in mice. Materials and methods: This observational study was performed between May and June 2014 in 21 male BALB/c mice aged 16-20 weeks. The animals were divided into three groups: pentobarbital (P), (n = 7); pentobarbital+fentanyl (P+ F), (n = 7); and ketamine+xylazine (K+X), (n = 7). Surface electrocardiography (ECG) electrodes were placed in lead II configuration. 'the tachogram of RR intervals was obtained after R waves were detected using the Pan-Tompkins real-time QRS recognition algorithm. Frequency-domain, time-domain, and nonlinear HRV analyses were performed. Results: The bradycardia effect was higher in the K+X group (p < 0.01). Time-domain indices were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). Very low frequency (VLF) power was significantly lower in group K+X compared to group P and group P+F (p < 0.01). Low frequency (LF) power, low frequency/high frequency (LF/HF) ratio, and total power (TP) were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). The detrended fluctuation analysis short-term parameter (DFA alpha(1)) was significantly higher in group K+X compared to group P+F (p < 0.05) and the long-term parameter (DFA alpha(2)) was lower in group K+X compared to group P (p < 0.05). Standard deviations SD1 and SD2 were higher in group K+X compared to group P (p < 0.001) and group P+F (p < 0.001), SD2/SD1 ratio was lower in group K+X compared to group P (p < 0.05) and group P+F (p < 0.05). Entropy measures did not differ between groups. Conclusion: HRV analyses, including nonlinear methods, indicated that a K+X combination reduces imbalance and disorder in the regulation of the autonomic nervous system (ANS) in comparison to both P and the P+F combination.
  • Article
    Citation - Scopus: 2
    Behavioral Immune System and Trypophobia
    (Klinik Psikiyatri Dergisi, 2022) Ozturk, Suleyman; Ceylan, Deniz; Demir, Ayse Banu; Kazdagli, Hasan; Erdeniz, Burak
    Pathogens, which are the source of infectious diseases, have imposed a strong selection pressure on human evo-lution as one of the most important causes of human death during the natural selection process. As a result of this, it is assumed that a variety of adaptations have evolved against infection threats and one of these adap-tations is the physiological immune system. However, activation of the physiological immune system can be quite costly for organisms in some cases, and therefore it has been recently proposed in evolutionary psychology that an adaptive system called behavioral immune sys-tem may have evolved in association with the proactive functional processes against pathogen threats. Furthermore, it was hypothesized that a number of psy-chopathologies might develop as a result of maladaptive processes affecting the functionality of this system, and one of these psychopathologies might be trypophobia. Trypophobia refers to a psychological disorder in which individuals experience aversion and disgust at excessive levels toward clusters of small objects such as holes and bumps. Following this, the current review was estab-lished within the framework of three distinct goals. Firstly, this review aimed to discuss the evolutionary basis and mechanisms of the behavioral immune system. Secondly, the review aimed to discuss the characteristic features and the etiological explanations of trypophobia. Finally, the review aimed to discuss how potential changes in the behavioral immune system might lead to the development of trypophobia.