TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Long-Stem Prosthesis for Intertrochanteric and Femoral Neck Fractures in the Elderly: Retrospective Comparison of Short-Term Clinical Outcomes(Galenos, 2021-04-09) Çekok, Kübra; Biçen, Çağdaş; Akdemir, Mehmet; Türken, Mehmet Aykut; Çekok, Fatma Kubra; Bıcen, Ahmet CagdasObjective: Hip fracture treatment in elderly patients remains challenging. This study aimed to evaluate short-term clinical results of long-stem cementless arthroplasty in elderly patients with femoral neck and intertrochanteric fractures. Materials and Methods: We collected data of patients we treated with long-stem cementless arthroplasty between January 2011 and December 2019 due to hip fractures. This study included 48 patients (>= 65 years of age) with femoral neck and intertrochanteric fractures. The patients underwent either bipolar or total hip arthroplasty. A 2-year follow-up was conducted in all the patients. Outcomes were evaluated with the Harris hip score (HHS), Koval categories, complications and hip and mid-thigh pain. We compared clinical results of patients with femoral neck fractures and those with intertrochanteric fractures. Results: The mean follow-up period was 57 (34-92) months. Sixteen patients had femoral neck fractures and 32 had intertrochanteric fractures. No difference in demographic characteristics and comorbidities was noted between groups. The mean preoperative Barthel index of activities of daily living score was 79. At the last follow-up, the mean HHS of the control group was 77 and the mean Koval categories score was 3. Revision surgeries were conducted in two patients due to dislocation. Infection was observed in one patient and was treated by debridement and anti-biotherapy. Implant loosening and periprosthetic fractures were not noted. Conclusion: With fair outcomes, long-stem cementless arthroplasty is a potential treatment for hip fractures in elderly patients. A longer follow-up to evaluate the efficacy of these prostheses is warranted.Article Ankilozan Spondilitli Bireylerde Hangi Solunum Eğitimi Daha Etkilidir: 360-Derece Ekspanse Diyafram Egzersizleri Mi, Standart Diyafram Egzersizleri Mi? Randomize Kontrollü Çalışma(2025-09-30) Urak, Özkan; Sari, Ismail; Gurpinar, Baris; Yeşilyurt, Seda YakıtAmaç: Solunum komplikasyonları genellikle asemptomatik olsa da Ankilozan Spondilit (AS) hastalarında önemli bir morbidite ve mortalite nedenidir. Egzersizin AS yönetimindeki kanıtlanmış faydalarına rağmen, geleneksel diyafram nefesi ile göğüs kafesinin tamamını hedefleyen çok boyutlu, yenilikçi yaklaşımların karşılaştırıldığı sınırlı sayıda çalışma bulunmaktadır. Bu çalışma, standart diyafram nefesi ile sensör destekli 360 derece ekspanse diyafram nefesi egzersizlerinin solunum fonksiyonu, hastalık aktivitesi ve fiziksel kapasite üzerindeki etkilerini değerlendirerek bu boşluğu doldurmayı amaçlamıştır. Gereç ve Yöntem: AS tanısı almış 50 birey, standart diyafram nefesi grubu (DG) veya 360 derece ekspanse diyafram nefesi grubu (360DG) olmak üzere rastgele iki gruba ayrılmıştır. Her iki gruba da altı hafta boyunca haftada iki kez denetimli egzersiz uygulanmıştır. Değerlendirilen sonuçlar arasında solunum fonksiyon testleri, maksimal inspiratuvar ve ekspiratuvar basınçlar (MIP/MEP) ve AS’ye özgü indeksler yer almıştır. Bulgular: Her iki grupta da işlevsel indeksler ve solunum parametrelerinde anlamlı iyileşmeler gözlemlenmiş, ancak gruplar arası farklar istatistiksel olarak anlamlı bulunmamıştır (p>0,05). Özellikle, DG grubunda FEV1/FVC oranında anlamlı bir artış (p = 0,017), 360DG grubunda ise FVC değerinde anlamlı bir artış (p = 0,007) saptanmıştır. Solunum kas gücü (MIP ve MEP) her iki grupta da anlamlı şekilde artmıştır (p<0,05). Sonuç: Bu randomize kontrollü çalışma, AS’de 360 derece ekspanse diyafram nefesi egzersizlerini değerlendiren ilk çalışmalardan biridir. Bulgular hem standart hem de sensör destekli nefes egzersizlerinin solunum ve fonksiyonel sonuçları iyileştirmede güvenli ve etkili olduğunu göstermektedir. Bu sonuçlar, fizyoterapistler ve klinisyenler için kişiye özel solunum eğitiminin AS rehabilitasyon programlarına entegre edilmesinin klinik önemini vurgulamakta ve hasta bakımını geliştirmek için esnek, kanıta dayalı stratejiler sunmaktadır.Article Citation - WoS: 1Citation - Scopus: 125-Hydroxyvitamin Levels in Sjögren’s Syndrome: Is It the Right Time to Dismiss the Case or Not(Walter de Gruyter GmbH, 2024-09-23) Sımsır, Ilgın Yıldırım; Tanigor, Goksel; Karabulut, Gonca; Barutcuoglu, Burcu; Yılmaz, ZevcetObjectives: This study aimed to investigate whether patients with primary Sjögren syndrome (SjS) have different levels of 25 OH-D3 (vitamin D) when compared to healthy populations and whether differences in 25 OH-D3 correlated with disease activity or markers. Methods: Eighty-eight female patients with SjS and 3,338 age-matched healthy female controls were included in this study. 25 OH-D3 levels were compared with healthy controls. Then the patients were stratified according to their 25 OH-D3 levels, either insufficient/deficient or normal (<50 nmol/L or ≥50 nmol/L). The disease activity was evaluated using The EULAR SjS disease activity index (ESSDAI) and its components. Correlation analyses were also performed for a possible correlation with disease characteristics and markers of activity. Results: No differences in 25 OH-D3 levels were found between SjS and healthy populations (p>0.05). No correla- tions were found between patient characteristics or labo- ratory values (p>0.05). Conclusions: This study did not find a link between disease characteristics and disease activity and 25 OH-D3 levels. Prospective studies with more patients should be conducted to reach a conclusion.Article Citation - WoS: 2Matrix Metalloproteinase-2 and -3 Levels in Patients With Behçet's Disease and Implication for the Presence of Vascular Aneurysm or Neurologic Involvement(AVES, 2023-08-24) Erten, Pınar Talu; Keser, Gökhan; Durusoy, Raika; Kocaer, Sinem Burcu; Aksu, KenanBackground: Behçet's disease is a systemic vasculitis affecting both arteries and veins, as well as causing recurrent inflammatory multiorgan disease. Vascular involvement is associated with increased mortality and morbidity. Matrix metalloproteinases are released at sites of inflammation and degrade various components of the extracellular matrix. Increased levels of metalloproteinase-9 and metalloproteinase- 2 have been previously reported in Behçet's disease. Methods: In this cross-sectional study, metalloproteinase-2 and metalloproteinase-3 serum levels were investigated in 103 patients with Behçet's disease and 69 healthy controls, using Invitrogen immunoassay human metalloproteinase-2 and metalloproteinase-3 ELISA kits. Results: Serum metalloproteinase-2 and metalloproteinase-3 levels were significantly higher in the Behçet's disease group compared to healthy controls. Besides, serum metalloproteinase-3 levels were significantly higher in subgroups of Behçet's disease with aneurysmal vascular involvement and with neurological involvement. However, metalloproteinase-2 and metalloproteinase-3 serum levels did not show a positive correlation with disease activity. Conclusion: Metalloproteinase-2 and -3 may contribute to the complex pathogenesis of Behçet's disease. More importantly, the detection of very high serum levels of metalloproteinase-3 may predict the formation of an aneurysm, or possibly the presence of neurological involvement in Behçet's disease and may lead the clinician to make an earlier diagnosis of these complications in young male patients with high risk.Article Citation - WoS: 2Citation - Scopus: 3Effects of Vertebral Fusion on Levels of Pro-Inflammatory and Catabolic Mediators in a Rabbit Model of Intervertebral Disc Degeneration(Turkish Assoc Orthopaedics Traumatology, 2021-05-27) Dumanlidag, Davut; Keles, Didem; Oktay, Gulgun; Kosay, CanObjective: The aim of this study was to explore the alterations in levels of pro-inflammatory and catabolic mediators following vertebral fusion in a rabbit model of intervertebral disc degeneration. Methods: In this study, 24 female New Zealand albino rabbits (aged 4 to 5 months and weighing 3 to 3.5 kg) were used. All the animals were randomly categorized into four groups, and dorsal spinal exposure of all lumbar vertebrae was routinely performed in each group. While disc degeneration was created in groups B, C, and D, spinal fusion was added to disc degeneration in groups C and D. Disc degeneration was typically created by puncturing the discs with an 18-gauge needle under the guidance of C-arm imaging. Fusion was achieved with posterior/posterolateral decortication and iliac bone grafts. The rabbits in groups A, B, and C were euthanized, and the discs were removed in the first week after the surgery. The rabbits in Group D were sacrificed, and the discs were harvested at 5 weeks after the surgery. The levels of Interleukin (IL)-1 beta, IL-6, Nitric Oxide (NO), Matrix Metalloproteinase (MMP)-3, MMP-13, and Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) in the discs were analyzed using enzyme-linked immunosorbent assay kits. Results: Significant increase was observed in the protein levels of both pro-inflammatory and catabolic mediators in disc degeneration groups (Group B, C, and D) compared to Group A. In the fusion groups (Group C and D), these increased mediators decreased, compared to non-fusion group (Group B), (IL1-beta P = 0.017, TIMP-1 P = 0.03, NO P = 0.03). However, there was no statistically significant difference in mediator levels between the short- and long-term fusion (Group C versus D). Conclusion: The results of this study have shown that a significant decrease in pro-inflammatory and catabolic mediators may be expected after vertebral fusion whereas there may be no significant difference between the first and fourth week of fusion surgery. These findings may contribute to clarifying the mechanism of action of vertebral fusion in the treatment of low back pain.