TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Effect of Coronary Artery Diseases on Ocular Perfusion(2025-02-26) Fatihoglu, Sefik Gorkem; Fatihoğlu, Özlem Ural; Topaloglu, Caner; Okan, TahaObjectives: This study aimed to evaluate the ocular perfusion of patients with ischemic coronary artery disease (CAD) using optical coherence tomography angiography. Patients and methods: A total of 62 patients (49 male, 13 female; mean age: 62.9±9.1 years; range, 35 to 78 years) with a diagnosis of CAD were enrolled in this study. The data were compared with 61 healthy controls (35 male, 26 female; mean age: 68.1±3.9 years; range, 46 to 76 years). Coronary artery disease diagnosis was defined as patients who underwent percutaneous coronary intervention after coronary angiography. Optical coherence tomography angiography was used to assess the choroid thickness, superficial capillary plexus, and deep capillary plexus vascular density parameters of each patient. Results: Choroid thickness was lower in the CAD group compared to the control group, but this decrease was not statistically significant. The results showed a significant decrease in superficial capillary plexus and deep capillary plexus parameters in CAD patients compared to healthy controls. Conclusion: Patients with CAD showed decreased flow density compared to healthy controls. The study concludes that CAD patients exhibit reduced ocular perfusion, which can be detected using optical coherence tomography angiography. This noninvasive technique could be an effective tool for monitoring ocular perfusion and detecting vascular abnormalities in patients with CAD.Article New Oral AntiCoagulants Use in Renal Disease and AF (NOACURE-AF) Where do We Stand?: An Expert Consensus View Using the Delphi Method(2021-07-02) Turk, Ugur Onsel; Alioglu, Emin; Ecder, Tevfik; Erdinler, Izzet Celal; Ok, Ercan; Ozluk, Ozlem Arican; Arıcı, Mustafa-Article Safety of Venography-Guided Extrathoracic Vein Puncture To Prevent Pneumothorax in Pacemaker Implantation(2023) Topaloğlu, CanerIntroduction: Pacemaker implantation is routinely and widely used around the world for a variety of heart conditions. The use of venography guidance is very important for the operator at the puncture site and prevent complications such as pneumothorax. The aim of this study is to determine the effect of venography in preventing complications and to compare the rate of pneumothorax between patients operated with and without venography guidance. Methods: A total of 539 consecutive patients who had a pacemaker implanted in our clinic between 2012 and 2022 were included in this study. Pacemaker type according to the number of leads used, diagnosis for pacemaker implantation, patient age, gender, concomitant chronic obstructive pulmonary disease (COPD), presence of defibrillator battery and lead, venography guidance were evaluated and their contribution to the complication of pneumothorax was analyzed. Results: The incidence of pneumothorax development was found to be 1.3% in our study. Venography guidance was found to be significantly protective against pneumothorax, as the patient group that developed pneumothorax consisted of patients who did not undergo venography at a high rate. It was determined that in the patient group that developed pneumothorax, there was a high percentage of patients between the ages of 18-65, of female gender, without concomitant COPD, with 2 leads inserted and with implantable cardioverter defibrillator (ICD) implantation (single/double leads). Our study revealed that routine venography in pacemaker implantation is an effective method to protect patients from pneumothorax as well as lead fracture. Discussion and Conclusion: Our study revealed that routine venography during pacemaker implantation is an effective method to protect patients from pneumothorax. Since blind puncture of venous structures increases the risk of complications, venography guidance can be used routinely in pacemaker implantation.Article Relationship Between Cryptogenic Ischemic Stroke and P Wave Peak Time(2024-07-01) Koyun, Emin; Koyuncu, İlhan; Dindaş, Ferhat; Doğduş, Mustafa; Öcek, LeventObjectives: This study aimed to examine whether P wave peak time (PWPT), a predictor of atrial fibrillation (AF), is significantly higher at the time of diagnosis in cryptogenic ischemic stroke patients. Patients and methods: The retrospective was conducted with 118 individuals (72 males, 46 females; mean age: 66.4±13.8 years) with cryptogenic ischemic stroke in the patient group and 118 individuals (77 males, 41 females; mean age: 63.2±16.1 years) without cerebrovascular disease in the control group between January 2021 and December 2023. The groups were compared regarding PWPT. Results: As a result of multivariate regression analysis, PWPT-D2 and PWPT-V1 were found to be independent predictors of cryptogenic ischemic stroke. In the ROC analysis, when PWPT-D2 was >51.5 msec, the sensitivity for the diagnosis of cryptogenic ischemic stroke was found to be 80%, and the specificity was 76%. When PWPT-V1 was >46 msec, the sensitivity for the diagnosis of cryptogenic ischemic stroke was found to be 75%, and the specificity was 73%. Conclusion: P wave peak time is an important predictor of cryptogenic ischemic stroke. The reason for the high PWPT level in these patients may be undetected AF. Therefore, longer-term rhythm Holter may be recommended in these patients.Conference Object Clinical Management Strategies of Cardiologists in Heart Failure With Reduced Ejection Fraction(Wiley, 2024) Kocabas, U. Umut; Ozcalik, E.; Kivrak, T.; Altin, C.; Turk, U. O.[No abstract available]Article Carotis Intima-Media Thickness, Coronary Calcium Score at Different Stages of Coronary Artery Disease(Dokuz Eylul Univ Inst Health Sciences, 2024-09-30) Okan, Taha; Doruk, Mehmet; Ozturk, Ali; Topaloglu, Caner; Yilmaz, Mehmet BirhanPurpose: Coronary Artery Calcium Score (CACS) and Carotid Artery Intima-Media Thickness (CIMT) are surrogate markers for atherosclerosis. CACS is a recognized indicator of coronary artery disease (CAD), but CIMT's role in CAD diagnosis is debated. This study aimed to assess how well CIMT and CACS predict CAD presence and severity as detected by coronary computed tomography angiography (CCTA). Materials and Methods: In the study, 88 participants (57 CAD and 31 controls) underwent coronary angiography and CACS calculation using computerized tomography and CIMT measured according to the guidelines. Patients with CAD were classified by CACT results and further subdivided by CACS into three groups: Group I (<100), Group II (100-300), and Group III (>= 300). The relationship between CIMT and CAD groups with zero Agatston scores, as well as the control group, was also examined. Results: The CACS had 82% sensitivity and 100% specificity for predicting CAD, excluding CAD with 75.6% specificity. A CIMT max cut-off of >= 0.78 mm showed 76% sensitivity and 54% specificity for CAD. A CIMT max cut-off of >= 1.03 mm had 93% specificity but only 35% sensitivity, while <= 0.59 mm excluded CAD with 96% specificity but just 10% sensitivity. Patients with CIMT levels between 0.59 mm and 1.03 mm may need further testing to assess CAD risk accurately. Conclusion: The CACS is more sensitive than CIMT in predicting CAD, and CIMT is not helpful when the CACS is zero. Determining an optimal CIMT cutoff for CAD prediction is challenging, and patients with CIMT between 0.59 mm and 1.03 mm may require additional testing.Article Citation - WoS: 2Citation - Scopus: 2A New Scoring System for the Evaluation of Ibrutinib-Associated Arrhythmias in Chronic Lymphocytic Leukemia: the ACEF Score(Turkish Society of Hematology, 2024-05-30) Ugur, Mehmet Can; Bilgir, Oktay; Dogdus, Mustafa; Koyuncu, İlhan; Senoz, Oktay; Koyun, Emin; Koyuncu, BetulAmaç: Kardiyak dokuda Bruton tirozin kinaz inhibisyonu, stres sırasında dokunun korunmasından sorumlu olan PI3K-AKT sinyal yolunun inhibisyonuna neden olur. Bu nedenle aritmi riskinde bir artış vardır. Bu çalışma, yaş, kreatinin ve ejeksiyon fraksiyonu komponentlerini temel alan ve basit bir puanlama sistemi olan Yaş-Kreatinin-Ejeksiyon Fraksiyonu (ACEF) skoru ile bu riskin tahmin edilebilmesini araştırmaktadır. Gereç ve Yöntemler: Kronik lenfositik lösemi (KLL) tanısı alan ve en az 1 yıldır ibrutinib tedavisi alan hastalar ekokardiyografi ve Holter elektrokardiyografi ile değerlendirildi ve sonuçlar tedavi almayan KLL hastalarından oluşan kontrol grubuyla karşılaştırıldı. ACEF skoru, yaş/sol ventriküler ejeksiyon fraksiyonu+1 (kreatinin >2,0 mg/dL ise) formülüyle hesaplandı. Bulgular: Hastaların aritmi gelişimi değerlendirildiğinde paroksismal atriyal fibrilasyon (PAF) dışındaki aritmi türleri açısından kontrol ve ibrutinib grupları arasında istatistiksel olarak anlamlı bir fark bulunmadı. PAF, ibrutinib kullanmayanlar ile kullananlar arasında %8’e karşı %22 (p=0,042) oranında meydana gelmekteydi. İbrutinib kullanan hastalarda ACEF skorunun >1,21 olması, PAF gelişimini %77 duyarlılık ve %75 özgüllükle öngörmekteydi (eğri altındaki alan: 0,830, %95 güven aralığı: 0,698-0,962, p<0,001). Sonuç: ACEF skoru, KLL tanısı alan ve ibrutinib başlanması planlanan hastalarda PAF gelişimini öngören bir risk skoru olarak kullanılabilir.Article Citation - WoS: 1Citation - Scopus: 1Myocardial Infarction in Young Adults: Diagnosis Begins Through Inspection(Kare Publ, 2024) Özpelit, Mehmet Emre; Kumral, Zeynep; Özpelit, Ebru; Çolak, AyseSpontan koroner arter diseksiyonu (SKAD), genellikle orta yaşlı kadınları etkileyen nadir bir akut koroner sendrom formudur. Genetik vaskülopatiler de dahil olmak üzere bağ dokusu hastalıkları SCAD’ye yol açan önemli predispozan durumlardan biridir. Bu yazıda, anterior miyokard enfarktüsü geçiren ve vasküler tip Ehler-Danlos sendromu tanısı alan 36 yaşında bir erkek hasta sunulmuş ve literatür gözden geçirilmiştir.Article Evaluation of the Relationship Between Diabetic Retinopathy and the Development of Left Atrial Stiffness in Patients With Diabetes Mellitus(AVES, 2023-10-25) Birdal, Oğuzhan; Saygı, Mehmet; Doğan, Remziye; Pay, Levent; Aksakal, Emrah; Topaloglu, Caner; Yıldırım, Mustafa; Aksu, UğurObjective: Based on several studies, atrial remodeling results in an increase in left atrial (LA) stiffness, which is indicative of a worsened reservoir function. A typical microvascular consequence of diabetes mellitus (DM) is diabetic retinopathy. Therefore, the objective of this study was to assess the factors that might be related to LA stiffness in DM patients. Materials and Methods: There were 200 DM patients in the study population. The LA stiffness value of 0.33 led to the division of the patients into 2 groups. According to these groups, the parameters to predict the development of the LA stiffness were investigated. Results: The patient population’s median age was 54.7 ± 9.4 years, and of them, 105 (52.5% of the popula- tion) were men. Retinopathy was substantially linked with LA stiffness. Interventricular septum thickness (B coefficient: 0.261, 95% CI 0.128; 0.394; P < .001), mitral annular plane systolic excursion (B coefficient: −0.350, 95% CI −0.489; −0.2212; P < 0.001), and retinopathy (B coefficient: 0.644, 95% CI 0.307; 0.983; P < .001) were identified as independent predictors of the progression of LA stiffness by the linear regression model. Conclusion: The results of the current investigation demonstrated a correlation between higher LA stiffness values and the presence of diabetic retinopathy in diabetic patients.Article The Relationship Between Hypothyroidism-Induced Autoantibodies, Tsh Levels, and Rdw, as an Inflammation Marker(2023-04-30) Aygün, Kemal; Demir, Tevfik; Gökdemir, Özden; Şişman, Ali RızaAim: Serum RDW grades were detected in patients with Hashimoto's thyroiditis. We aimed to use RDW to detect increased cardiovascular events in patients, increased oxidative stress, and inflammation without the need for an additional cost. Methods: We collected 904 persons results, 462 patients which have Hashimoto's thyroiditis, and 442 age and sex-matched control cases were comprised in our study. From laboratory measurements of the patients’ records were utilized such as hemogram, hs-CRP, fasting blood glucose, insulin, C-peptide, kidney function tests, liver function tests (ALT, AST), serum lipids (total cholesterol, triglyceride, HDL, LDL), anti-Tg, and anti-TPO, FT3, FT4, TSH levels. Results: RDW was considerably scaled up in case group compared to control group (Hashimoto's thyroiditis =10.08 ± 4.48%, control = 8.95 ± 6.68%, p <0.05). Also, MPV was increased in the study group(p<0.05). hs-CRP showed a statistically significant positive correlation between the level of RDW. Conclusion: Although the exact mechanism is still not fully understood, increased RDW levels in individuals with Hashimoto’s thyroiditis, possibly related to ongoing subclinical inflammation, neurohumoral activation, and changes resulting from oxidative stress in such patients. RDW is potentially a valuable tool for assessing cardiovascular diseases among patients diagnosed with Hashimoto's thyroiditis.