TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Histomorphometric Analysis of the Effects of Grape Seed Extract (vitis Vinifera) and Low-Level Laser Therapy (lllt) on Fracture Healing(2020) Kara, Muhammed İsa; İnan, Sevinç; Aydemir, Işıl; Taysı, Seyithan; Aras, Mutan Hamdi; Altundağ Kahraman, Sevil; Ege, Bilal; Kahraman, Sevil Altundag; Kara, İsa; Akgül, HasanAim: In this study, we aim to investigate the effects of supplementary Grape Seed Extract (GSE) and Low-Level Laser Therapy (LLLT)on fracture healing, oxidant and anti-oxidant system in experimental mandible fractures.Materials and Methods: 48 Wistar Albino rats (adult male, n=48) were used in our study. For all the subjects, a vertical fracture linethrough molar teeth in right mandibles was created and internally fixed using a four-hole microplate and four micro screws. Firstly,these subjects were randomly divided into 4 main groups (Control, GSE, LLLT, GSE+LLLLT) of 12 animals each, and then these wereindividually separated into two sub-groups of 7th and 21st days. The number of groups (n=6) was 8 in total. GSE of 300 mg/kg/day were provided to the subjects before they were sacrificed. LLLT of 23 J/cm2 was administered to two different points alongwith the fracture line at intervals of 48 hours for 7 days in the 7th day sub-groups and for 14 days in the 21st day sub-groups. Afterthe procedure, while biochemical values such as TAS, TOS and OSI are measured; histopathologically it was examined in termsof capillary number and width, inflammatory cell, fibroblast count, collagen fibers, osteoblast count, ossification and mature boneformations.Results: For biochemical analyses, there was statistically significant difference only in TAS values on either the 7th or 21st day forthe groups. Histological analyses showed that mandibular fracture healing were significantly better in the GSE and GSE+LLLT groupscompared to the control group. The group of only LLLT had limited recovery while the combination of GSE+LLLT was the best forossification.Conclusions: It is concluded that GSE may be one of the potential methods to accelerate fracture healings in mandibular fracturescommon in oral and maxillofacial surgery clinic and thus help patients recover in shorter time, and however LLLT can have positiveeffects on the process of ossification and recovery only when combined with the extract, which may result in better outcomes inclinical use.Article Citation - WoS: 4Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement(Duzce Univ, 2019-03-25) Cesur, Mine Gecgelen; Onal, Tuna; Bilgin, Mehmet Dincer; Sirin, Fevziye Burcu; Inan, Sevinc; Koken, Ergun Cem; Alkan, Afra; Cesur, GökhanObjective: The goal of our study is to assess the effects of low intensity pulsed ultrasound on orthodontic tooth movement in rats. Methods: For this study, 40 adult male Wistar albino rats (12-weeks old age) were used from the Animal Laboratory at Adnan Menderes University. Rats were divided into four groups each of ten. Group 1 was the untreated as a control. In group 2, an orthodontic spring was used to move teeth. For groups 3 and 4, orthodontic treatment was combined with low intensity pulsed ultrasound at 16 J/cm2 or 48 J/cm2 for 14 days, respectively. Tooth movement was measured at the last day of treatment. Serum bone alkaline phosphatase (BALP) and C-telopeptide type I collagen (CTX-I) levels were analyzed biochemically. The number of osteoclasts, osteoblasts and inflammatory cells, capillary density and new bone formation was determined histologically. Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta) were assessed using immunohistochemical staining. Results: BALP and CTX-I levels in group 4 were significantly higher compared to control (p<0.05). Tooth movement and the number of osteoclasts, inflammatory cells and capillary density in group 4 were significantly greater than group 2 (p<0.05). The intensity levels of RANKL and OPG in group 4 were significantly greater than group 2 (p<0.05). Conclusions: Ultrasound is a noninvasive application and promising therapy for accelerating bone remodelling during orthodontic tooth movement.