TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Carotis Intima-Media Thickness, Coronary Calcium Score at Different Stages of Coronary Artery Disease(Dokuz Eylul Univ Inst Health Sciences, 2024-09-30) Okan, Taha; Doruk, Mehmet; Ozturk, Ali; Topaloglu, Caner; Yilmaz, Mehmet BirhanPurpose: Coronary Artery Calcium Score (CACS) and Carotid Artery Intima-Media Thickness (CIMT) are surrogate markers for atherosclerosis. CACS is a recognized indicator of coronary artery disease (CAD), but CIMT's role in CAD diagnosis is debated. This study aimed to assess how well CIMT and CACS predict CAD presence and severity as detected by coronary computed tomography angiography (CCTA). Materials and Methods: In the study, 88 participants (57 CAD and 31 controls) underwent coronary angiography and CACS calculation using computerized tomography and CIMT measured according to the guidelines. Patients with CAD were classified by CACT results and further subdivided by CACS into three groups: Group I (<100), Group II (100-300), and Group III (>= 300). The relationship between CIMT and CAD groups with zero Agatston scores, as well as the control group, was also examined. Results: The CACS had 82% sensitivity and 100% specificity for predicting CAD, excluding CAD with 75.6% specificity. A CIMT max cut-off of >= 0.78 mm showed 76% sensitivity and 54% specificity for CAD. A CIMT max cut-off of >= 1.03 mm had 93% specificity but only 35% sensitivity, while <= 0.59 mm excluded CAD with 96% specificity but just 10% sensitivity. Patients with CIMT levels between 0.59 mm and 1.03 mm may need further testing to assess CAD risk accurately. Conclusion: The CACS is more sensitive than CIMT in predicting CAD, and CIMT is not helpful when the CACS is zero. Determining an optimal CIMT cutoff for CAD prediction is challenging, and patients with CIMT between 0.59 mm and 1.03 mm may require additional testing.Article Aconitine Impedes Cell Motility in Mda-Mb Breast Cancer Cells(Dokuz Eylul Univ Inst Health Sciences, 2024-09-30) Keles, Didem; Sipahi, Murat; Surer, Seniz Inanc; Oktay, GulgunPurpose: Aconitine, a potent alkaloid from Aconitum plants, has shown promising anticancer properties. The aim of the study is to investigate the effects of aconitine on lateral migration, and matrix metalloproteinase (MMP) activity in MDA-MB-231 triple-negative breast cancer cells. Material and Methods: A WST-1 viability assay was conducted to determine the effect of aconitine on the viability of MDA-MB-231 cells. Following treatment with non-cytotoxic doses of aconitine, lateral migration was evaluated through wound healing assays. Additionally, gelatin zymography was conducted to analyze MMP-2 and MMP-9 activity and secretion levels. Results: Aconitine concentrations up to 200 mu M did not significantly affect cell viability for up to 72 hours, whereas higher doses (400-600 mu M) reduced viability in a time-dependent manner. Aconitine at 200 mu M showed a trend towards decreased lateral motility, with a significant reduction at 9 hours post-treatment. Gelatin zymography revealed no alterations in MMP-2 and MMP-9 activity or secretion levels following aconitine treatment. Conclusion: Aconitine demonstrates limited efficacy in modulating the migratory capacity of MDA-MB231 cells and does not affect gelatinase activity. Further investigation into underlying mechanisms is necessary, potentially leading to novel therapeutic strategies for triple-negative breast cancer.Article Changes in Respiratory Muscle Pressure of Healthy Individuals With Different Levels of Immersion in Water: Observational Study(Dokuz Eylul Univ Inst Health Sciences, 2023-09-30) Gurpinar, Baris; Özyürek, Seher; Elvan, Ata; Tükel, ŞerminPurpose: Understanding the physiological effects of immersion, particularly on pulmonary dynamics in healthy individuals is important to predict and interpret the physiological responds in unhealthy group. The aim of our study is to evaluate the inspiratory and expiratory muscle strength and cough strength in healthy individuals during water immersion at different water depths. Methods: A cross-sectional study was conducted in 24 healthy individuals with the mean age 20.0 years. Respiratory muscle strength test and cough force were tested on dry land and in pool at iliac crests, xiphoid appendix of the sternum and clavicles levels. Measurements were randomized at each level. The Friedman test was used for repeated measures with Wilcoxon signed ranks test with Bonferroni correction was applies to compare the variables. Results: A significant difference between dry land and immersion in water of different levels for MEP (p=0.001) and PEF (p= 0.015). Multiple comparisons showed no difference between levels in PEF (p<0.001), whereas MEP values measured in clavicles level was significantly higher than both dry land and iliac crest level (p<0.0125). Conclusion: Clavicle level immersion alters respiratory muscle strength when compared with the values measured out of the water and immersed at the iliac crest level in healthy individuals.Article Citation - WoS: 3The Effects of Respiratory Muscle Functions on Trunk Muscle Endurance in Healthy Young Adults(Dokuz Eylul Univ Inst Health Sciences, 2023-05-31) Aktan, Özge Ocaker; Aktan, Rıdvan; Yakut, Hazal; Yakut, Hazal; Ozalevli, Sevgi; Kara, Bilge; Ocaker Aktan, OzgePurpose: Respiratory muscles play a dual role in breathing and trunk stability during activities. The relationship between respiratory muscle functions and trunk stability has not yet been clarified. The aim of the study was to examine the effects of respiratory muscle functions on trunk muscle endurance in healthy young adults. Methods: McGill's trunk muscle endurance tests, which consist of trunk flexion endurance test (FE), Sorensen test (ST) and Side Bridge test (SB), were used to evaluate the participants' trunk muscle endurance. Respiratory muscle strength was evaluated by measuring intraoral maximal inspiratory and expiratory pressures using an intraoral pressure meter device. The respiratory muscle endurance test was performed with the incremental threshold load protocol using a threshold IMT device. Results: A total of 51 healthy young adults, with a mean age of 21.8 ± 3.2 years, were evaluated. The results of the linear regression models were significantly explained 46% of the variance in the SB and 38% in the FE, (for SB Adj R2=0.46, F=21.40, p< 0.001 and for FE Adj R2=0.38, F=15.65, p< 0.001). Respiratory muscle endurance contributed 30% to the endurance of the trunk flexor muscles, while respiratory muscle strength contributed only 8%. Similarly, respiratory muscle endurance contributed 38% to the endurance of the trunk lateral flexor muscles, while respiratory muscle strength contributed only 8%. Conclusion: Although respiratory muscle strength and respiratory muscle endurance were independent contributors to trunk muscle endurance, respiratory muscle endurance more affected trunk muscle endurance than respiratory muscle strength in healthy young adults.Article The Responses of Radiology Professionals To the Covid-19 Pandemic(Dokuz Eylul Univ Inst Health Sciences, 2022-09-29) Alkan, Turkan; Çilengiroğlu, Özgül VupaPurpose: This study aimed to investigate radiology professionals’ response to the impact of COVID-19 on professional practice. In addition, the fear and anxiety levels experienced by this workforce during the pandemic process were investigated. Methods: A quantitative cross-sectional study was conducted. The questionnaire covered information on demographic characteristics, the Coronavirus Overviews and Impacts, the Coronavirus Anxiety Scale (CAS), and the Fear of COVID-19 Scale. Logistic regression was used to model the relationship between \"CAS\" and \"Fear\" scores and variables. Data collected was analysed using the Statistical Package for Social Sciences (v.24). Results: A total of 290 responses were received, comprising 21.7% radiologists and 78.3% technicians. The key contributor factors to work-related stress were found to be the fear of COVID-19 infection, with 63.8%, the increase in workload, with 17.6% and inadequate personal protective equipment (PPE), with 11%. The percentages of anxiety were 75.6% for technician and 24.4% for radiologist. It was found that there was a significant association between \"CAS\" score and the gender variable (p=0.030<0.05), and similarly, between \"Fear\" score and gender (p-value=0.003) and age (p-value=0.080) variables. The women are 2.205 times more likely to be anxious than men (p=0.033) and 2.106 times more likely to be fear (p=0.003). Conclusion: Almost half of the participants reported adequate PPE availability during the study period. Despite this, most feared being infected with COVID-19. Therefore, it is important to provide timely and adequate personnel training, adequate availability of PPE and regular psychosocial support for radiology professinals, during future pandemics.Article Citation - WoS: 3A Comparative Study on Indoor Radon Levels Between the Lung Cancer and Cancer Free Groups in Izmir Province, Turkey(Dokuz Eylul Univ Inst Health Sciences, 2021-09-20) Ozbay, Turkan; Karadeniz, Ozlem; Cilengiroglu, Ozgul Vupa; Durak, Hatice; Eser, SultanPurpose: Izmir is the province of Turkey with the highest lung cancer incidences for males, therefore a comparative study was performed in particular districts of Izmir in 2013. In the study, it was aimed to assess the association between lung cancer risk and indoor radon. Methods: Patients diagnosed with lung cancer between 2010 and 2011 were selected from the database of the Izmir Cancer Registry (ICR). Measurements of indoor radon concentrations were performed in a total of 117 locations using the SSNTD (Solid State Nuclear Track Detectors) method with LR-115 detectors. Indoor radon concentration measured in homes of patients with lung cancer and cancer free group were compared statistically. Results: The indoor Radon (222Rn) activity concentration detected ranged from 165 to 487 Bq/m3, for the lung cancer group, from 28 to 367 Bq/m(3) for the cancer free group, with geometric means of 269 Bq/m3 and 123 Bq/m(3), respectively. Conclusion: According to the logistic regression model, as radon concentration and package/year increased, the rate of cancer increased multiple folds. These results suggest that indoor radon levels may contribute to higher rates of lung cancer for Izmir compared to the rest of the country, and indoor radon levels may be a contributory factor in this phenomenon.Article Possible Therapeutic Role of Cholinergic Agonists on Covid-19 Related Inflammatory Response(Dokuz Eylul Univ Inst Health Sciences, 2021-02-26) Baris, Elif; Arici, M. AylinSevere acute respiratory syndrome-corona virus-2 (SARS-CoV-2) or coronavirus infectious disease (COVID-19) outbreak is continued to spread all over the world recently with the high mortality and morbidity rates. It is also known well COVID-19 is leading causes of acute lung injury and acute respiratory distress syndrome (ARDS), sepsis and multiorgan failure. Current treatment of COVID-19, includes different strategies targeting preventing viral replication or treating secondary infections and decreasing exaggerated immune response. Although antiviral, antimicrobial, immunomodulatory agents including anti-cytokines and glucocorticoids have been currently applied, there is lack of a specific treatment for COVID-19. In this review, possible therapeutic roles of cholinomimetic drugs in the control of COVID-19 related inflammation is discussed.Article Thyroid Hormone Replacement in Total Thyroidectomized Patients : Symptomatic and Metabolic Effects of Levothyroxine Monotherapy(Dokuz Eylul Univ Inst Health Sciences, 2021-05-27) Akdeniz, Didem Dereli; Oztop, Mehmet BurakPurpose: In this study, we planned to investigate the effects of L-thyroxine monotherapy on total thyroidectomized patients. The main goal of our study is to evaluate if FT4 therapy is good enough not only to maintain euthyroidism but also to provide a good quality of life and a balance in their metabolism Methods: In this study, we retrospectively evaluated 30 total thyroidectomized patients without malignancy. We compared their thyroid hormone levels, glucose metabolism, lipid metabolism, their body mass indexes, and their symptoms of thyroid problems before surgery and after one year of treatment of L-thyroxine monotherapy. Results: the pre-op and post-op thyroid hormone levels were both in the normal range but the FT4 levels were significantly higher in the 1st year results than pre-op results (1,42 +/- 0,18 vs 1,29 +/- 0,49 respectively P=0,005*) The FT3 levels also were in the normal range in pre and 1st year post-op but post-op FT3 levels were significantly lower than pre-op levels (2,25 +/- 0,27 vs 2,92 +/- 0,49 retrospectively P<0,001*). The pre-op and postop TSH levels were euthyroid and not statistically significant. The patients tended to gain weight and it seems to be because of a tendency of being insulin resistant. (HOMA-IR pre-op and post-op were 2,2 +/- 1,1 vs 2,6 +/- 1,1 P<0,01 retrospectively; pre-op and post-op weights were 69,8 +/- 9,5 vs 71,1 +/- 10,3 P=0,006* respectively). Even all of them were euthyroid the patients tended to feel hypothyroidism symptoms. Conclusion: This study demonstrates that even though they are euthyroid with FT4 treatment total thyroidectomized patients may suffer from hypothyroidism signs and symptoms and metabolic deterioration may occur in such patients. We recommend that we should aim not only to normalize s-TSH levels but also to normalize patients' metabolic parameters and improve the quality of daily life when regulating our treatments.Article Citation - WoS: 2Validation of the Rapid Assessment of Physical Activity Questionnaire in Older Patients With Chronic Obstructive Pulmonary Disease(Dokuz Eylul Univ Inst Health Sciences, 2021-09-20) Aktan, Ridvan; Ozalevli, Sevgi; Yalcinkaya, Gamze; Alpaydin, Aylin Ozgen; Sevinc, CanPurpose: There are not many questionnaires that have proven validity and reliability in evaluating the level of physical activity in older patients with chronic obstructive pulmonary disease (COPD). In clinical and scientific studies, it is important to quickly determine the physical activity level of patients in terms of time management. The aim of the study was to examine the validity of the rapid assessment of physical activity (RAPA) questionnaire in older patients with COPD. Methods: A total of 105 older patients with COPD surveyed the short form of the International Physical Activity Questionnaire (IPAQ-SF) and after 2 weeks RAPA questionnaire as well. The IPAQ-SF was accepted as the gold standard for physical activity assessment in COPD. Furthermore, patients were assessed for a 6-min walking test (6MWT) and perceived dyspnea (with modified medical research dyspnea scale (mMRC)). Correlation coefficients (r) was used for the relationship between RAPA and IPAQ-SF. Results: There were significant positive correlations between RAPA and IPAQ-SF total score (r = 0.968, p<0.001), 6MWT (r = 0.626, p<0.001), in addition to significant negative correlation between the RAPA and mMRC scores (r = -0.454, p<0.001). The RAPA showed good sensitivity (87.5%) and a specificity (100%) value. Positive and negative predictive values of the RAPA were 100% and 96.4% respectively. Conclusion: This study showed the RAPA was an easy-to-use, valid, and reliable questionnaire to measure physical activity levels in older patients with COPD.Article 1,25-Dihydroxyvitamin D3 Induces N-Myc Downstream Regulated Gene-2 Expression in Papillary Thyroid Carcinoma Cells(Dokuz Eylul Univ Inst Health Sciences, 2020) Sipahi, Murat; Bartik, Didem Keles; Doruk, Mehmet; Bayraktar, Firat; Oktay, GulgunPurpose: In addition to its role in serum calcium homeostasis, the anti-tumor function of 1,25-dihydroxyvitamin D-3 (calcitriol) in cancer development is well established. N-myc Downstream Regulated Gene 2 which functions as a tumor suppressor gene has recently been shown to be downregulated in various cancer leading to increased tumor incidence, progression and metastasis. The goal of this study was to investigate the possible effects of calcitriol treatment on NDRG2 expression in BCPAP papillary thyroid carcinoma cells. Methods: The experiments were carried on human primary thyroid follicular epithelial cells (Nthy-ori-3-1), and human papillary thyroid carcinoma cells (BCPAP). The half maximal inhibitory concentration (IC 50) of calcitriol on BCPAP cells was determined by WST-1 assay. BCPAP cells were treated with 15 and 30 mu M calcitriol for 24, 48, and 72 hours, respectively. Basal NDGR2 expression in Nthy-ori-3-1 and BCPAP cells as well as the alterations on NDRG2 expression in calcitriol treated BCPAP cells were evaluated with western blot. Results: A significant downregulation of NDRG2 was observed in BCPAP cells when compared to Nthy-ori-3-1 cells (p<0.01). IC50 dose of calcitriol was found to be 64, 54 and 43 mu M for 24, 48 and 72 hours, respectively. NDRG2 protein expression levels were significantly increased in 30 mu M calcitriol treated BCPAP cells after 48 hours (p<0.05). Conclusions: Calcitriol induced NDRG2 protein expression in BCPAP cells. We predict that calcitriol increased NDRG2 protein levels in BCPAP cells via c-Myc repression, which is upregulated by aberrant Wnt/beta-catenin signaling. Further investigation is required to enlighten the possible effect mechanisms of calcitriol in BCPAP cells.