TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Primer Nöroendokrin Meme Karsinomu ve Nöroendokrin Difeeransiyasyonlu Meme Karsinomunun Radyolojik Özellikleri(2025) Koc, Ali Murat; Altın, Levent; Adibelli, Zehra Hilal; Özdemir, Özlem; Tunçez, Hülya Çetin; Çavdar, Demet Kocatepe; Zengel, BahaGiriş: Primer nöroendokrin meme karsinomu (NMK) ve nöroendokrin diferansiye meme kanseri (NDBC) meme kanserinin nadir görülen alt tipleridir. Amacımız bu heterojen tümör grubunun görüntüleme özelliklerini incelemek ve histopatolojik bulgularını tartışmaktır. Gereç ve Yöntemler: Bu çalışmada hastanemiz veri kayıt arşivi taranarak 5 yıl içerisinde NMK ve NDBC tanısı alan hastalar incelendi. Ultrasonografi, mamografi ve dinamik manyetik rezonans görüntüleme (MRG) özellikleri Meme Görüntüleme Raporlama ve Veri Sistemi (BI- RADS) 5. sözlüğüne göre retrospektif olarak değerlendirildi. Östrojen reseptörü, progesteron reseptörü, Her2 ekspresyonu, ki67 oranı ve histolojik derece kaydedildi. Ki67 oranına göre radyolojik özellikler karşılaştırıldı. Bulgular: Çalışmaya 47 hastaya ait 51 lezyon (5/51 primer NMK, 46/51 NDBC) dahil edildi. NDBC grubunda en sık görülen histolojik tip %81 (37/46) oranında invaziv duktal karsinomdu. Ultrasonografide lezyonların %85,7'si düzensiz şekilli, %52,4'ü mikrolobüle ve %92,9'u cilde dik uzun eksenli idi. Hastaların %77,3'ünde (34/44) asimetri ve doku distorsiyonu görüldü. 79,5'inde mikrokalsifikasyon vardı. Mikrokalsifikasyon ile ki67 değeri arasında istatistiksel olarak anlamlı bir korelasyon vardı. Mikrokalsifikasyonlu lezyonların çoğunda ki67 değeri %20'nin altındaydı (p=0,002). MRG'de lezyonların %83,3'ü hızlı kontrast tutulumu gösterirken, %56,3'ü yıkanma gösterdi. Difüzyon kısıtlaması %93,8 oranında gözlendi. Lezyonların %96'sında östrojen veya progesteron reseptörü pozitifti. Tartışma: NMK ve NDBC, radyolojik olarak düzensiz sınırlara sahip, uzun aksı cilde dik, heterojen kontrast tutulumu ve difüzyon kısıtlılığı gösteren kitleler olarak görülür. Histopatolojik olarak sıklıkla hormon pozitif ve Her2 negatiftirler. Bu konuda geniş hasta serileri ile prospektif çalışmalara ihtiyaç vardır.Article Şant Disfonksiyonu Tanısında Optik Sinir Kılıfı Çapı Ölçüm Yönteminin Tanısal Etkinliğinin Değerlendirilmesi(2025-12-12) Ozgiray, Erkin; Akay, Ali; Akarca, Funda Karbek; Yalçınlı, Sercan; Can, ÖzgeGiriş: Ventriküloperitoneal (VP) şant uygulaması, hidrosefali yönetiminde yaygın olarak kullanılan bir nöroşirürjik girişimdir. Bu yönteme bağlı komplikasyonlar arasında yer alan şant disfonksiyonu, hem sıklığı hem de ciddi klinik sonuçlara yol açma potansiyeli nedeniyle önemli bir morbidite nedenidir. Şant disfonksiyonu, intrakraniyal basınç artışına ve buna bağlı nörolojik bozulmaya neden olabilmektedir. Günümüzde tanıda yaygın olarak kullanılan kranial bilgisayarlı tomografi ve şant grafisi gibi görüntüleme yöntemleri, çoğu durumda tek başına yeterli tanısal doğruluk sağlayamamaktadır. Bu çalışma, yatak başı ultrasonografi ile elde edilen optik sinir kılıf çapı (OSKÇ) ölçümlerinin VP şant disfonksiyonu tanısındaki tanısal performansını ve klinik uygulanabilirliğini değerlendirmeyi amaçlamaktadır. Yöntemler: Bu prospektif gözlemsel çalışmaya, 2016-2018 yılları arasında bir üniversite hastanesi acil servisine ventriküloperitoneal (VP) şantı bulunan ve şant disfonksiyonu şüphesiyle başvuran, 18-65 yaş arası hastalar dahil edildi. Ateş, baş ağrısı, kusma, bilinç değişikliği ve nöbet gibi semptomları olan hastalar çalışmaya alındı. Optik sinir kılıf çapı (OSKÇ) ölçümleri, eğitim almış acil tıp hekimleri tarafından gerçekleştirildi. Şant disfonksiyonu protokollerine uygun olarak tüm hastalara kraniyal bilgisayarlı tomografi (BT), şant serisi ve batın ultrasonografisi uygulandı. Şant disfonksiyonu tanısı, tüm klinik ve radyolojik bulguların birlikte değerlendirilmesi sonucunda bir beyin cerrahisi uzmanı tarafından konuldu ve nöroşirurjik değerlendirme altın standart olarak kabul edildi. Bulgular: Çalışmaya 43 hasta dahil edildi. Yaş ortalaması 43±19,5 idi Hastaların OSKÇ ortalaması 4,70±0,98 idi. BT bulguları eski BT ile kıyaslandığında %60 hastada stabildi. OSKÇ şant disfonksiyonu tanısında istatistiksel olarak anlamlı saptanmadı. Şant disfonksiyonu tanısı koymada OSKÇ duyarlılık %62.5 ve özgüllük %62.9 olarak bulundu Altı hastanın acil servise 2 hafta içinde tekrar başvurduğu görüldü. İkinci başvuruda OSKÇ ortalaması 4,93±1,02 idi disfonksiyon olarak değerlendirilidi. Sonuç: Çalışmamızda şant disfonksiyonunu göstermede OSKÇ ölçümümün istatistiksel olarak anlamlı olmadığını saptadık. Ancak gelecekteki tanı algoritmalarındaki şant disfonksiyonu tanısında OSKÇ ölçümünün potansiyel rollerinin daha fazla araştırılması gereklidir.Article Investigation of Glass Ceiling Syndrome Among Radiation Professionals: a Comparative Analysis(Dokuz Eylul Univ inst Health Sciences, 2025-05-31) Şişman, Gizem; Çilengiroğlu, Özgül Vupa; Alkan, TurkanBackground and Purpose: This study investigates the perception of the glass ceiling syndrome among radiology, nuclear medicine, and radiation oncology technicians in healthcare institutions in Turkey. Methods: A comparative approach was used to examine the prevalence and impact of the glass ceiling on female workers. Data was collected via questionnaires from 311 participants in Turkey, and analyzed using descriptive statistics, chi-square analysis, and independent sample tests. Results: The results indicate that 78.1% of the participants were women, 64% were medical imaging technicians and 65.3% were employed in private institutions. A significant difference was found in the total and subscale scores of the glass ceiling scale (excluding mentoring) based on gender (p<0.05). Conclusion: This study enhances understanding of gender dynamics among radiation workers and highlights the need for targeted interventions to address the glass ceiling syndrome. The findings provide key insights for promoting workforce equity and organizational development in healthcare institutions.Article Carotis Intima-Media Thickness, Coronary Calcium Score at Different Stages of Coronary Artery Disease(Dokuz Eylul Univ Inst Health Sciences, 2024-09-30) Okan, Taha; Doruk, Mehmet; Ozturk, Ali; Topaloglu, Caner; Yilmaz, Mehmet BirhanPurpose: Coronary Artery Calcium Score (CACS) and Carotid Artery Intima-Media Thickness (CIMT) are surrogate markers for atherosclerosis. CACS is a recognized indicator of coronary artery disease (CAD), but CIMT's role in CAD diagnosis is debated. This study aimed to assess how well CIMT and CACS predict CAD presence and severity as detected by coronary computed tomography angiography (CCTA). Materials and Methods: In the study, 88 participants (57 CAD and 31 controls) underwent coronary angiography and CACS calculation using computerized tomography and CIMT measured according to the guidelines. Patients with CAD were classified by CACT results and further subdivided by CACS into three groups: Group I (<100), Group II (100-300), and Group III (>= 300). The relationship between CIMT and CAD groups with zero Agatston scores, as well as the control group, was also examined. Results: The CACS had 82% sensitivity and 100% specificity for predicting CAD, excluding CAD with 75.6% specificity. A CIMT max cut-off of >= 0.78 mm showed 76% sensitivity and 54% specificity for CAD. A CIMT max cut-off of >= 1.03 mm had 93% specificity but only 35% sensitivity, while <= 0.59 mm excluded CAD with 96% specificity but just 10% sensitivity. Patients with CIMT levels between 0.59 mm and 1.03 mm may need further testing to assess CAD risk accurately. Conclusion: The CACS is more sensitive than CIMT in predicting CAD, and CIMT is not helpful when the CACS is zero. Determining an optimal CIMT cutoff for CAD prediction is challenging, and patients with CIMT between 0.59 mm and 1.03 mm may require additional testing.Article Can Volumetric Magnetic Resonance Imaging Evaluations Be Helpful in the Follow-Up of Cognitive Functions in Cognitively Normal Parkinson's Disease Patients?(Tubitak Scientific & Technological Research Council Turkey, 2024-08-23) Uysal, Hasan Armağan; Hunerli, Duygu; Çakmur, Raif; Dönmez Çolakoğlu, Beril; Ada, Emel; Yener, Görsev; Çolakoğlu, Beril DönmezBackground/aim: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson's disease (PDCN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients. Materials and methods: Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA). Attention and executive functions were evaluated using the Wechsler memory scale-revised (WMS-R) digit span test and trail making test (TMT) part A and part B, the Stroop test, semantic and phonemic fluency tests, and clock drawing test. Magnetic resonance imaging (MRI) was acquired according to the Alzheimer's disease neuroimaging initiative (ADNI) protocol. Results: There were no significant differences among groups regarding age, sex, handedness, and years of education. In the comparison of the PD-CN group and the HC group, there was a statistical decrease in the total animal scores, lexical fluency, TMT part A and TMT part B scores in the PD-CN group. Subcortical gray matter volumes (GMV) were significantly lower in PD-CN patients. The PD-CN group had a significantly reduced total volume of right putamen and left angular gyrus compared to that in the HC group. We observed that putamen and angular gyrus volumes were lower in PD-CN patients. On the other hand, TMT part B may be a useful pretest in detecting the conversion of mild cognitive impairment in PD. Conclusion: Significant MRI volumetric measurements and neuropsychological test batteries can be helpful in the clinical follow-up in PD-CN patients.Article Citation - WoS: 7Citation - Scopus: 10Investigation of the Role of Convolutional Neural Network Architectures in the Diagnosis of Glaucoma Using Color Fundus Photography(Turkish Ophthalmological Soc, 2022-06-29) Atalay, Eray; Ozalp, Onur; Devecioglu, Ozer Can; Erdogan, Hakika; İnce, Türker; Yildirim, NilgunObjectives: To evaluate the performance of convolutional neural network (CNN) architectures to distinguish eyes with glaucoma from normal eyes. Materials and Methods: A total of 9,950 fundus photographs of 5,388 patients from the database of Eskisehir Osmangazi University Faculty of Medicine Ophthalmology Clinic were labelled as glaucoma, glaucoma suspect, or normal by three different experienced ophthalmologists. The categorized fundus photographs were evaluated using a state-of-the-art two-dimensional CNN and compared with deep residual networks (ResNet) and very deep neural networks (VGG). The accuracy, sensitivity, and specificity of glaucoma detection with the different algorithms were evaluated using a dataset of 238 normal and 320 glaucomatous fundus photographs. For the detection of suspected glaucoma, ResNet-101 architectures were tested with a data set of 170 normal, 170 glaucoma, and 167 glaucoma-suspect fundus photographs. Results: Accuracy, sensitivity, and specificity in detecting glaucoma were 96.2%, 99.5%, and 93.7% with ResNet-50; 97.4 degrees A, 97.8%, and 97.1% with ResNet-101; 98.9%, 100%, and 98.1% with VGG-19, and 99.4%, 100%, and 99% with the 2D CNN, respectively. Accuracy, sensitivity, and specificity values in distinguishing glaucoma suspects from normal eyes were 62%, 68%, and 56% and those for differentiating glaucoma from suspected glaucoma were 92%, 81%, and 97%, respectively. While 55 photographs could be evaluated in 2 seconds with CNN, a clinician spent an average of 24.2 seconds to evaluate a single photograph. Conclusion: An appropriately designed and trained CNN was able to distinguish glaucoma with high accuracy even with a small number of fundus photographs. Conclusion: An appropriately designed and trained CNN was able to distinguish glaucoma with high accuracy even with a small number of fundus photographs.Article The Responses of Radiology Professionals To the Covid-19 Pandemic(Dokuz Eylul Univ Inst Health Sciences, 2022-09-29) Alkan, Turkan; Çilengiroğlu, Özgül VupaPurpose: This study aimed to investigate radiology professionals’ response to the impact of COVID-19 on professional practice. In addition, the fear and anxiety levels experienced by this workforce during the pandemic process were investigated. Methods: A quantitative cross-sectional study was conducted. The questionnaire covered information on demographic characteristics, the Coronavirus Overviews and Impacts, the Coronavirus Anxiety Scale (CAS), and the Fear of COVID-19 Scale. Logistic regression was used to model the relationship between \"CAS\" and \"Fear\" scores and variables. Data collected was analysed using the Statistical Package for Social Sciences (v.24). Results: A total of 290 responses were received, comprising 21.7% radiologists and 78.3% technicians. The key contributor factors to work-related stress were found to be the fear of COVID-19 infection, with 63.8%, the increase in workload, with 17.6% and inadequate personal protective equipment (PPE), with 11%. The percentages of anxiety were 75.6% for technician and 24.4% for radiologist. It was found that there was a significant association between \"CAS\" score and the gender variable (p=0.030<0.05), and similarly, between \"Fear\" score and gender (p-value=0.003) and age (p-value=0.080) variables. The women are 2.205 times more likely to be anxious than men (p=0.033) and 2.106 times more likely to be fear (p=0.003). Conclusion: Almost half of the participants reported adequate PPE availability during the study period. Despite this, most feared being infected with COVID-19. Therefore, it is important to provide timely and adequate personnel training, adequate availability of PPE and regular psychosocial support for radiology professinals, during future pandemics.