TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4

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  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    A New Scoring System for the Evaluation of Ibrutinib-Associated Arrhythmias in Chronic Lymphocytic Leukemia: the ACEF Score
    (Turkish Society of Hematology, 2024-05-30) Ugur, Mehmet Can; Bilgir, Oktay; Dogdus, Mustafa; Koyuncu, İlhan; Senoz, Oktay; Koyun, Emin; Koyuncu, Betul
    Amaç: Kardiyak dokuda Bruton tirozin kinaz inhibisyonu, stres sırasında dokunun korunmasından sorumlu olan PI3K-AKT sinyal yolunun inhibisyonuna neden olur. Bu nedenle aritmi riskinde bir artış vardır. Bu çalışma, yaş, kreatinin ve ejeksiyon fraksiyonu komponentlerini temel alan ve basit bir puanlama sistemi olan Yaş-Kreatinin-Ejeksiyon Fraksiyonu (ACEF) skoru ile bu riskin tahmin edilebilmesini araştırmaktadır. Gereç ve Yöntemler: Kronik lenfositik lösemi (KLL) tanısı alan ve en az 1 yıldır ibrutinib tedavisi alan hastalar ekokardiyografi ve Holter elektrokardiyografi ile değerlendirildi ve sonuçlar tedavi almayan KLL hastalarından oluşan kontrol grubuyla karşılaştırıldı. ACEF skoru, yaş/sol ventriküler ejeksiyon fraksiyonu+1 (kreatinin >2,0 mg/dL ise) formülüyle hesaplandı. Bulgular: Hastaların aritmi gelişimi değerlendirildiğinde paroksismal atriyal fibrilasyon (PAF) dışındaki aritmi türleri açısından kontrol ve ibrutinib grupları arasında istatistiksel olarak anlamlı bir fark bulunmadı. PAF, ibrutinib kullanmayanlar ile kullananlar arasında %8’e karşı %22 (p=0,042) oranında meydana gelmekteydi. İbrutinib kullanan hastalarda ACEF skorunun >1,21 olması, PAF gelişimini %77 duyarlılık ve %75 özgüllükle öngörmekteydi (eğri altındaki alan: 0,830, %95 güven aralığı: 0,698-0,962, p<0,001). Sonuç: ACEF skoru, KLL tanısı alan ve ibrutinib başlanması planlanan hastalarda PAF gelişimini öngören bir risk skoru olarak kullanılabilir.
  • Article
    Citation - WoS: 1
    Detection of Alzheimer's Dementia by Using Deep Time-Frequency Feature Extraction
    (AVES, 2024-01-30) Karabiber Cura, Özlem; Türe, H. Sabiha; Akan, Aydin; Cura, Ozlem Karabiber
    Alzheimer's disease (AD), a neurological condition connected with aging, causes cognitive deterioration and has a substantial influence on a patient's daily activities. One of the most widely used clinical methods for examining how AD affects the brain is the electroencephalogram (EEG). Handcraft calculating descriptive features for machine learning algorithms requires time and frequently increases computational complexity. Deep networks provide a practical solution to feature extraction compared to handcraft feature extraction. The proposed work employs a time-frequency (TF) representation and a deep feature extraction-based approach to detect EEG segments in control subjects (CS) and AD patients. To create EEG segments'TF representations, high-resolution synchrosqueezing transform (SST) and traditional short-time Fourier transform (STFT) approaches are utilized. For deep feature extraction, SST and STFT magnitudes are used. The collected features are classified using a variety of classifiers to determine the EEG segments of CS and AD patients. In comparison to the SST method, the STFT-based deep feature extraction strategy produced improved classification accuracy between 79.56% and 92.96%.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 8
    Solid Pseudopapillary Neoplasms of the Pancreas: Case Series With a Review of the Literature
    (Aves, 2020-12-15) Uguz, Alper; Unalp, Omer Vedat; Akpinar, Goksever; Karaca, Can Avni; Oruc, Nevin; Nart, Deniz; Yilmaz, Funda; Aydın, Ahmet; Coker, Ahmet
    Background/Aims: The solid pseudopapillary neoplasms are quite rare tumors of the pancreas, comprising roughly 1-2% of all pancreatic neoplasms. It has a low malignant potential and usually affects young females. Despite increasing number of articles in the last decade, there is still debate on the pathogenesis, malignant potential and optimal surgical strategy for the solid pseudopapillary neoplasms. Materials and Methods: Medical recordings of 326 patients who were operated due to pancreatic mass were retrospectively analyzed. Patient demographics, presenting symptoms, surgical and pathologic characteristics of the tumor, postsurgical course, long-term survival, and other relevant data were extracted from patients' charts. Results: Majority of the patients were female in consistency with the classic data in the literature. All the patients underwent curative intent resections. Tumors were commonly localized in the tail of the pancreas making distal pancreatectomy the most commonly performed surgical procedure. Mean tumor diameter was 5.8 centimeters with tumor sizes ranging from 1 to 19 cm. Conclusion: The solid pseudopapillary neoplasms of the pancreas is a rare tumor with low malignant potential, which is more common in females of reproductive age, with abdominal pain being their most common presentation. The short-term outcomes in patients following surgical R0 resection are excellent. However, proximal placement of the tumor and female gender may have slightly worse prognosis. We hope that our findings from a series of patients represent a contribution to the existing literature on SPN, and authors declare their willingness to provide further details for future meta-analyses.