TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Impact of Inspiratory Muscle Strength and Lung Function on Functional Exercise Capacity in Post-Myocardial Infarction Patients: A Cross-Sectional Study(Galenos Publishing House, 2025-09-18) Aktan, Rıdvan; Ozalevli, Sevgi; Dursun, Huseyin; Aktan, Özge Ocaker; Ocaker Aktan, OzgeOBJECTIVE: This study aims to investigate the contribution of lung function and respiratory muscle strength in predicting functional exercise capacity in post-myocardial infarction (MI) subjects. MATERIAL AND METHODS: This cross-sectional study included 56 stable post-MI subjects. Lung function was assessed using a digital spirometer, and respiratory muscle strength was measured using an intraoral pressure meter. The 6-minute walk distance (6MWD) was conducted to assess functional exercise capacity. Correlations and multiple regression analyses were performed to evaluate predictors of 6MWD, considering demographic factors, lung function, and respiratory muscle strength. The Bland-Altman plot was used to investigate the agreement between observed and predicted 6MWDs. RESULTS: Significant positive correlations were found between 6MWD and forced vital capacity (FVC)%predicted (r = 0.528, P = 0.022) and maximum inspiratory pressure (MIP)%predicted (r = 0.640, P = 0.022). Age (r = -0.350, P = 0.008) and body mass index (BMI) (r= -0.561, P < 0.001) were negatively correlated with 6MWD. The best regression model included MIP%predicted (β = 0.332, P = 0.002), BMI (β = -0.264, P = 0.012), being male (β = 0.262, P = 0.003), age (β = -0.210, P = 0.020), and FVC%predicted (β = 0.219, P = 0.026) as significant unique contributors. The final multiple linear regression model was significant [F (5, 50) = 19.08, P < 0.001] and explained 65.6% of the variance (R2 = 0.656) in the 6MWD. CONCLUSION: Lung function and respiratory muscle strength significantly contribute to functional exercise capacity in post-MI. This study emphasizes the importance of comprehensive respiratory function assessments in rehabilitation strategies to improve exercise capacity in patients with post-MI.Article Citation - WoS: 2Citation - Scopus: 2A New Scoring System for the Evaluation of Ibrutinib-Associated Arrhythmias in Chronic Lymphocytic Leukemia: the ACEF Score(Turkish Society of Hematology, 2024-05-30) Ugur, Mehmet Can; Bilgir, Oktay; Dogdus, Mustafa; Koyuncu, İlhan; Senoz, Oktay; Koyun, Emin; Koyuncu, BetulAmaç: Kardiyak dokuda Bruton tirozin kinaz inhibisyonu, stres sırasında dokunun korunmasından sorumlu olan PI3K-AKT sinyal yolunun inhibisyonuna neden olur. Bu nedenle aritmi riskinde bir artış vardır. Bu çalışma, yaş, kreatinin ve ejeksiyon fraksiyonu komponentlerini temel alan ve basit bir puanlama sistemi olan Yaş-Kreatinin-Ejeksiyon Fraksiyonu (ACEF) skoru ile bu riskin tahmin edilebilmesini araştırmaktadır. Gereç ve Yöntemler: Kronik lenfositik lösemi (KLL) tanısı alan ve en az 1 yıldır ibrutinib tedavisi alan hastalar ekokardiyografi ve Holter elektrokardiyografi ile değerlendirildi ve sonuçlar tedavi almayan KLL hastalarından oluşan kontrol grubuyla karşılaştırıldı. ACEF skoru, yaş/sol ventriküler ejeksiyon fraksiyonu+1 (kreatinin >2,0 mg/dL ise) formülüyle hesaplandı. Bulgular: Hastaların aritmi gelişimi değerlendirildiğinde paroksismal atriyal fibrilasyon (PAF) dışındaki aritmi türleri açısından kontrol ve ibrutinib grupları arasında istatistiksel olarak anlamlı bir fark bulunmadı. PAF, ibrutinib kullanmayanlar ile kullananlar arasında %8’e karşı %22 (p=0,042) oranında meydana gelmekteydi. İbrutinib kullanan hastalarda ACEF skorunun >1,21 olması, PAF gelişimini %77 duyarlılık ve %75 özgüllükle öngörmekteydi (eğri altındaki alan: 0,830, %95 güven aralığı: 0,698-0,962, p<0,001). Sonuç: ACEF skoru, KLL tanısı alan ve ibrutinib başlanması planlanan hastalarda PAF gelişimini öngören bir risk skoru olarak kullanılabilir.Conference Object Real-World Evaluation of Anticoagulant Treatment Patterns in Patients With Atrial Fibrillation: Data From Multicenter Rota Study [2022](Kare Publ, 2023) Kocabas, Umut; Ergin, Isil; Yavuz, Veysel; Murat, Selda; Ozdemir, Ibrahim; Genc, Omer; Altin, Cihan; Özçalık, Emre; Şengör, Büşra Güvendi; Sen, Taner; Kaplan, Mehmet; Dal, Ahmet; Dogdus, Mustafa; Şahin, Şeyda[Abstract Not Available]Article Citation - WoS: 18Citation - Scopus: 23Urban and Rural Differences in Hypertension Risk Factors in Turkey(Aves, 2017) Dastan, Ilker; Erem, Ayşegül; Cetinkaya, VolkanObjective: Existing literature shows considerable regional differences in terms of hypertension (HT) prevalence in Turkey. The purpose of this study was to analyze some of the known HT risk factors contributing to the variations between urban and rural areas of Turkey in HT development. Methods: We used data from the 2011 Chronic Diseases and Risk Factors Survey that was conducted by the Turkish Ministry of Health on a representative sample of the Turkish adult population aged 20 years or more (n=16.227). HT was defined as having at least one of the following: a mean systolic/diastolic blood pressure of at least 140/90 mm Hg, a previously diagnosed disease, or use of antihypertensive medication. Stepwise multiple logistic regression analysis was used to estimate HT risk factors in urban and rural settings. Results: Although the HT prevalence was higher in rural areas (28.4%) than in urban areas (23.9%), in this study, urbanization was found to be a contributing factor in multivariate regression analysis. Furthermore, separate regressions for urban and rural settings revealed that age, obesity, diabetes, hyperlipidemia, and smoking were independently and positively associated (p<0.05) with HT in both settings, while marital status, employment type, mental health, and lifestyle patterns; nutritional habits; and amount of physical activity and sedentary time (p<0.05) were risk indicators in urban areas only. Conclusion: The findings of our study demonstrate that contributory factors show some variations between urban and rural settings, and on gender within each setting. Taking into account the variations between urban and rural areas in HT development may provide greater insight into the design of prevention strategies.