TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article New Oral AntiCoagulants Use in Renal Disease and AF (NOACURE-AF) Where do We Stand?: An Expert Consensus View Using the Delphi Method(2021-07-02) Turk, Ugur Onsel; Alioglu, Emin; Ecder, Tevfik; Erdinler, Izzet Celal; Ok, Ercan; Ozluk, Ozlem Arican; Arıcı, Mustafa-Article Citation - WoS: 3Citation - Scopus: 5Current Status of Kidney Replacement Therapy in Türkiye: a Summary of 2022 Turkish Society of Nephrology Registry Report(Aves, 2024-04-09) Seyahi, Nurhan; Kocyigit, Ismail; Eren, Necmi; Tonbul, Halil Zeki; Tatar, Erhan; Yilmaz, Zulfukar; Ates, Kenan; Oguz, Ebru GokBackground: Turkish Society of Nephrology registry collects data on hemodialysis, peritoneal dialysis, and transplantation annually. Registry reports are printed every year as a booklet, and this is the 33rd year of registry reports. The registry is in close collaboration with international registries. Methods: In this paper, we summarized data from the 2022 registry report; additionally, we also provided yearly trends of managing end-stage kidney disease. Results: The number of patients on kidney replacement therapy increases; at the end of 2022, 86 665 patients were on kidney replacement therapy. The prevalence and incidence of end-stage kidney disease were 1016.2 and 160.9 per million population, respectively. Diabetes was the most common cause of end-stage kidney disease. Hemodialysis (71.22%) was the most common type of treatment modality, followed by transplantation (24.68%) and peritoneal dialysis (4.1%). Conclusion: End-stage kidney disease is a critical and growing health problem for our country. The renal registry of the Turkish Ssociety of Nephrology is one of the leading tools for providing current and sound data on this public health problem.Article Investigation of Neuraminidase 1 Gene Association in Henoch-Schönlein Purpura (hsp) With Renal Involvement(Pamukkale University, 2022-07-01) Yılmaz, N.B.; Ertan, P.; Yüksel, S.; Neşe, N.; Dinç Horasan, Gönül; Berdeli, A.H.; Horasan, Gönül Dinç; Bahçeci, Nezihe BilgePurpose: HSP is a common small vessel vasculitis. It is the most common cause of non-thrombocytopenic purpura in childhood. The role of genes in etiopathogenesis of the disease, which has not yet been clearly elucidated, is being emphasized. Many genes called sialidases are being studied and is thought that the NEU1 gene may be particularly important in the etiopathogenesis of HSP. The aim of this study is to investigate the role of the NEU1 gene in the etiopathogenesis of HSP and its relation to renal involvement. Materials and methods: Fifty patients followed in the Celal Bayar University Hafsa Sultan Hospital Pediatric Nephrology Department, with the diagnosis of HSP renal involvement were included into the study. For the control group, age and gender matched 50 cases were accepted among the outpatients admitted to Pediatric Department without any chronic diseases. NEU1 gene mutation analysis was performed in blood samples of both patient and control groups by using the Sanger DNA sequencing method. Results: NEU1 genetic mutation was not detected in any HSP patient with renal involvement and control group. Conclusion: In our study, the NEU 1 gene was not found to be associated with HSP nephritis. No changes were detected in the investigated regions of the NEU1 gene. © 2022, Pamukkale University. All rights reserved.Article Knowledge, Attitudes, and Opinions of Hepatitis B Virus Carrier Male Patients About the Disease(Doc Design Informatics Co Ltd, 2022-09-28) Digrak, Ebru; Tezel, AyferObjectives: The study was conducted to evaluate the knowledge, attitudes, and opinions of male patients infected with the hepatitis B virus about their disease. Methods: This descriptive study was conducted in a military hospital in Ankara between July 2016 - July 2017. The study population consisted of 244 male patients admitted to the Infectious Diseases Clinic of the hospital within one year. No sample selection was made, and 208 patients accepted to participate were included in the study. The research data were collected by a questionnaire form consisting of 28 questions prepared by the researchers in line with the literature. For statistical analysis, IBM SPSS Statistics for Windows. Version 22.0 program was used. Results: Of the patients, 86.5% were single, 50% were primary school graduates, 65.4% were self-employed, and their mean age was 22.67 +/- 2.9. According to the data, 53.4% of the patients were HBeAg-negative, and 46.6% were HBeAg-positive chronic hepatitis B patients. Healthcare personnel was the information source for 51.9% of the patients, and 80.8% felt the need to get more information about their disease. 88.4% of the patients stated that hepatitis B disease could be transmitted through the bloodstream, and 80.7% of them stated that being vaccinated prevented them from being sick. 86.5% of the patients stated that the purpose of the treatment of hepatitis B disease was to prevent the progression of the disease. Conclusions: According to the study's results, we determined that the patients' knowledge and attitudes about their diseases were insufficient.Article The Radiological Analysis of The Effects Ofraloxifene, Nitric-Oxide and Estrogen on Scoliosis: Abipedal C57bl6 Mice Model(2020-10-01) Demirkıran, H. Gökhan; Baş, Can Emre; Acaroğlu, Emre; Akel, İbrahim; Demirkiran, GokhanObjective: Raloxifene (RLX), estrogen and nitric oxide (NO) medications were showed to be related to scoliosis, but the complex mechanism has not yet been elucidated. The prevention and non-surgical treatment of scoliosis may be achieved with these drugs since they are safe for use in humans. We aimed to investigate the effects of oestrogen, RLX and NO on scoliosis progression, bone mineral density and sagittal plan deformities.Materials and Methods: One hundred and fifty-two C57BL6 mice were grouped into bipedal Estrogen, bipedal RLX, bipedal NO, bipedal control and quadrupedal control groups. All of the animals’ forelimbs and tails were amputated, except for the quadrupedal group (n=28), and followedup for five weeks. Estrogen, NO and RLX groups received orally administered Estrogen, NO and RLX after the $5^th$ week for 35 weeks. Anteroposterior and lateral X-ray imaging were done at the$5^th$, $20^th$ and $40^th$ weeks and bone mineral density measurements were done at the $20^th$ and $40^th$ weeks.Results: There was no significant difference in mean Cobb angles between the groups at the fifth, $20^th$ and $40^th$ weeks (p=0.917, p=0.066, p=0.562, respectively). In contrast, a significant increase in mean Cobb angles was found in the quadrupedal group between the $20^th$ and $40^th$ weeks. In addition, no significant difference was found between the groups in terms of scoliosis incidence at the fifth and $20^th$ weeks (p=1.000, p=0.132, respectively). However, when the scoliosis progression was investigated, a decreasing tendency was found in the RLX group compared to the other groups. Although there was a decreasing tendency in terms of the thoracic kyphosis angles and pelvic incidence between the $20^th$ and $40^th$ weeks in all groups, no statistical difference was found. Spinosacral angles increased significantly between the $20^th$ and $40^th$ weeks in all groups, except the quadrupedal group. There was a significant increase of the bone mineral density in the RLX group (p=0.041). Conclusion: RLX may decrease scoliosis progression in a C57BL/6 mice model and increase the bone mineral density. Unlike previous studies, the quadrupedal mice group had a tendency to increase scoliosis progression between the $20^th$ and $40^th$weeksReview Citation - Scopus: 1New Oral Anticoagulants Use in Renal Disease and Af (noacure-Af) - Where Do We Stand?: an Expert Consensus View Using the Delphi Method(Turkish Society of Cardiology, 2021-07-02) Arici M.; Ecder T.; Erdinler I.; Ok E.; Özlük Ö.A.; Türk U.Ö.; Alio?lu E.; Arici, Mustafa; Erdinler, Izzet; Özlük, Özlem Arican; Ecder, Tevfik; Türk, Uǧur Önsel; Ok, Ercan; Alioǧlu, Emin[No abstract available]Article Citation - Scopus: 3Clinical Impact of Hepatitis C Virus Genomic Variations(Ankara Microbiology Society, 2015-10-08) Ergünay K.; Abacioglu H.; Ergünay, Koray; Abacioglu, HakanHepatitis C virus (HCV) is a globally-dispersed agent of chronic hepatitis with a significant public health threat, affecting over 110 million individuals throughout the world. The increased risk for chronicity after exposure and the lack of a protective vaccine make HCV is a leading infectious cause of cirrhosis, liver failure requiring transplantation and hepatocellular carcinoma. The replicative process and infection dynamics in the host enable HCV to generate an array of closely-related but non-identical genetic variants known as quasispecies in the infected individuals. Pathogenesis and outcome in HCV infections are directly affected by the virus genetic heterogeneity, reflected as the emergence of quasispecies in infected individuals. The evolution of these highly-diverse viral populations in the host directly influences the disease course, via providing a pool of variants capable of resuming viral replication under extrinsic and/or intrinsic selective pressures. Viral quasispecies go through several alterations during the course of the infection, and provide a background for the selection of escape mutants from the host humoral and cell-mediated immune responses and antiviral treatment. Supported by the robust next generation sequencing techniques, recent studies have provided significant insights on the genomic diversity and progression as well as on the origin and the epidemiology of HCV. This review provides an overview of the mechanisms of HCV genetic variability, and the interactions with the host, that affects clinical disease, covering viral and host determinants of humoral and cell-mediated immune responses, alterations during the early and late stages of the infection and disease progression leading to chronicity. In addition, current findings in virus evolution and epidemiology were briefly interpreted from the inter-species and population perspectives. The impact of viral genomic heterogeneity on antiviral treatment in the era of direct-acting agents is also discussed, along with an overview of current methods employed for the characterization of viral diversity.Article Citation - WoS: 8Citation - Scopus: 7Evaluation of Demographic and Clinical Characteristics of Female Patients Presenting With Minoca and Differences Between Male Patients: a Subgroup Analysis of Minoca-Tr Registry(Kare Publ, 2022-01-06) Gok, Gulay; Coner, Ali; Cinar, Tufan; Kilic, Salih; Yenercag, Mustafa; Oz, Ahmet; Ekmekci, Cenk; Türk, Uğur Önsel; Zoghi, Mehdi; Ergene, Asim OktayObjective: Although the prevalence and rate of myocardial infarction with non-obstructive coronary arteries (MINOCA) are higher in women than in men in previous cohorts, potential demographic and clinical differences between women who are diagnosed with MINOCA versus myocardial infarction with obstructive coronary arteries (MIOCA) have not been studied till date. In this study, we aimed to document these characteristics and to compare them between female patients with MINOCA and MIOCA. Methods: The study was a subgroup analysis of the MINO-CA-TR study. The study was a multi-center, observational cohort study that was conducted in Turkey between March 2018 and October 2018. In this study, 477 (29.3%) female patients who had been diagnosed with acute myocardial infarction were evaluated. Results: Of these women, 49 (10.3%) were diagnosed with MINOCA (mean age 58.9 +/- 12.9 years) and 428 (89.7%) had a final diagnosis of MIOCA (mean age 67.4 +/- 11.8 years). The prevalence of hypertension, hyperlipidemia, and diabetes mellitus was significantly lower in the MINOCA group than in the MIOCA group. In addition, the MINOCA group had higher rates of recent flu history and non-ST elevation myocardial infarction (NSTEMI) presentation than the MIOCA group. There were significant clinical differences in patients with MINOCA in terms of sex. The female patients were older, had higher systolic blood pressures, and lower hemoglobin levels than male patients. Conclusion: The study revealed that the prevalence of traditional coronary artery disease risk factors was lower in female patients with MINOCA than in those who had final diagnosis of MIOCA.Article Citation - WoS: 3Citation - Scopus: 3A Minimally Invasive Transfer Method of Mesenchymal Stem Cells To the Intact Periodontal Ligament of Rat Teeth: a Preliminary Study(Tubitak Scientific & Technical Research Council Turkey, 2018-10-25) Gul Amuk, Nisa; Kurt, Gokmen; Kartal Yandim, Melis; Adan, Aysun; Baran, Yusuf; Amuk, Nisa Gul; Yandım, Melis KartalThe aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were used for this preliminary study. MSCs were obtained from bones of two animals and were labeled with green fluorescent protein (GFP). Four animals were randomly selected for MSC injection, while 4 animals served as a control group. Samples were prepared for histological analysis, Cox-2 mRNA expression polymerase chain reaction analysis, and fluorescent microscopy evaluation. The number of total cells, number of osteoclastic cells, and Cox-2 mRNA expression levels of the periodontal tissue of teeth were calculated. The number of total cells was increased with MSC injections in PDL significantly (P < 0.001). The number of osteoclastic cells and Cox-2 mRNA expression were found to be similar for the two groups. GFP-labeled MSCs were observed with an expected luminescence on the smear samples of the PDL with transferred MSCs. The results of this preliminary study demonstrate successful evidence of transferring MSCs to intact FIX in a nonsurgical way and offer a minimally invasive procedure for transfer of MSCs to periodontal tissues.Review Article Citation - WoS: 2Citation - Scopus: 2Senior Moments Are Never-Ending Times When You Are Old (are They?): First Step of Turquoise Project(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2022) Oz, Didem; Yildirim, Zerrin; Kiyi, Ilayda; Ozbek, Yagmur; Kulac, Ibrahim; Erkol, Gokhan; Tihan, Tarik; Yener, Görsev; Erkol, Gökhan; Gürvit, HakanIntroduction: The number of dementia patients is increasing in Turkey,, as well as all over the world. However, we do not know how much the society knows about dementia. The aim of this study is to evaluate people's concept of dementia, their awareness of dementia research and treatment, whether dementia and forgetfulness are considered normal in old age, and whether having dementia is associated with a lack of mental abilities. Methods: A Dementia Awareness Questionnaire was created in the form of a self-report questionnaire, consisting of 20 questions and using a five-point Likert-type answering method in order to question participants' information about dementia. In addition, we asked for demographic information such as age, gender, occupation, education level of the participants, as well as whether they have had relatives diagnosed with a neurodegenerative disease. The surveys were administered online. Results: A total of 1551 participants from 53 cities were included in the study. Approximately half of the participants did not know the definition of dementia, 20.9% thought that dementia and Alzheimer's disease were the same; 50.4% considered forgetfulness, and 55.2% considered dementia as a natural consequence of aging. While 34.5% of the participants thought that dementia patients could be dangerous, 10.3% thought they could not continue living as a part of society. While 38.5% of healthcare professionals do not know the definition of dementia, 18.5% of them say that dementia and Alzheimer's disease are the same, 58.5% think that dementia patients are not fit to make their own decisions, 40.6% believe that dementia patients have criminal liability. 15.8% of healthcare professionals thought that dementia is only seen in elderly people; 21.4% thought that dementia, and 49.2% thought that forgetfulness was a result of normal aging. Conclusion: Our study confirms that dementia is still an unknown concept in society and among healthcare professionals. It is widely believed that forgetfulness and dementia are part of normal aging, and there is no cure for dementia. This study, which we have done in order to understand the level of dementia awareness in Turkish society, reveals the necessity for research on dementia and studies on how to increase dementia awareness.