TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Citation - WoS: 2Citation - Scopus: 2A New Scoring System for the Evaluation of Ibrutinib-Associated Arrhythmias in Chronic Lymphocytic Leukemia: the ACEF Score(Turkish Society of Hematology, 2024-05-30) Ugur, Mehmet Can; Bilgir, Oktay; Dogdus, Mustafa; Koyuncu, İlhan; Senoz, Oktay; Koyun, Emin; Koyuncu, BetulAmaç: Kardiyak dokuda Bruton tirozin kinaz inhibisyonu, stres sırasında dokunun korunmasından sorumlu olan PI3K-AKT sinyal yolunun inhibisyonuna neden olur. Bu nedenle aritmi riskinde bir artış vardır. Bu çalışma, yaş, kreatinin ve ejeksiyon fraksiyonu komponentlerini temel alan ve basit bir puanlama sistemi olan Yaş-Kreatinin-Ejeksiyon Fraksiyonu (ACEF) skoru ile bu riskin tahmin edilebilmesini araştırmaktadır. Gereç ve Yöntemler: Kronik lenfositik lösemi (KLL) tanısı alan ve en az 1 yıldır ibrutinib tedavisi alan hastalar ekokardiyografi ve Holter elektrokardiyografi ile değerlendirildi ve sonuçlar tedavi almayan KLL hastalarından oluşan kontrol grubuyla karşılaştırıldı. ACEF skoru, yaş/sol ventriküler ejeksiyon fraksiyonu+1 (kreatinin >2,0 mg/dL ise) formülüyle hesaplandı. Bulgular: Hastaların aritmi gelişimi değerlendirildiğinde paroksismal atriyal fibrilasyon (PAF) dışındaki aritmi türleri açısından kontrol ve ibrutinib grupları arasında istatistiksel olarak anlamlı bir fark bulunmadı. PAF, ibrutinib kullanmayanlar ile kullananlar arasında %8’e karşı %22 (p=0,042) oranında meydana gelmekteydi. İbrutinib kullanan hastalarda ACEF skorunun >1,21 olması, PAF gelişimini %77 duyarlılık ve %75 özgüllükle öngörmekteydi (eğri altındaki alan: 0,830, %95 güven aralığı: 0,698-0,962, p<0,001). Sonuç: ACEF skoru, KLL tanısı alan ve ibrutinib başlanması planlanan hastalarda PAF gelişimini öngören bir risk skoru olarak kullanılabilir.Conference Object Real-World Evaluation of Anticoagulant Treatment Patterns in Patients With Atrial Fibrillation: Data From Multicenter Rota Study [2022](Kare Publ, 2023) Kocabas, Umut; Ergin, Isil; Yavuz, Veysel; Murat, Selda; Ozdemir, Ibrahim; Genc, Omer; Altin, Cihan; Özçalık, Emre; Şengör, Büşra Güvendi; Sen, Taner; Kaplan, Mehmet; Dal, Ahmet; Dogdus, Mustafa; Şahin, Şeyda[Abstract Not Available]Article Citation - WoS: 9Citation - Scopus: 9Classical Heart Rate Variability and Non-Linear Heart Rate Analysis in Mice Under Na-Pentobarbital and Ketamine/Xylazine Anesthesia(Tubitak Scientific & Technical Research Council Turkey, 2022-01-01) Kazdagli, Hasan; Ozel, Hasan Fehmi; Ozbek, Mustafa; Alpay, Suheda; Alenbey, MuruvvetBackground/aim: Anesthetics are often used in animal experiments to achieve immobilization and relieve pain. However, many anesthetics can alter the dynamics of cardiovascular systems. We aimed to compare the effects of two frequently used anesthetics agents on heart rate variability (HRV) parameters in mice. Materials and methods: This observational study was performed between May and June 2014 in 21 male BALB/c mice aged 16-20 weeks. The animals were divided into three groups: pentobarbital (P), (n = 7); pentobarbital+fentanyl (P+ F), (n = 7); and ketamine+xylazine (K+X), (n = 7). Surface electrocardiography (ECG) electrodes were placed in lead II configuration. 'the tachogram of RR intervals was obtained after R waves were detected using the Pan-Tompkins real-time QRS recognition algorithm. Frequency-domain, time-domain, and nonlinear HRV analyses were performed. Results: The bradycardia effect was higher in the K+X group (p < 0.01). Time-domain indices were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). Very low frequency (VLF) power was significantly lower in group K+X compared to group P and group P+F (p < 0.01). Low frequency (LF) power, low frequency/high frequency (LF/HF) ratio, and total power (TP) were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). The detrended fluctuation analysis short-term parameter (DFA alpha(1)) was significantly higher in group K+X compared to group P+F (p < 0.05) and the long-term parameter (DFA alpha(2)) was lower in group K+X compared to group P (p < 0.05). Standard deviations SD1 and SD2 were higher in group K+X compared to group P (p < 0.001) and group P+F (p < 0.001), SD2/SD1 ratio was lower in group K+X compared to group P (p < 0.05) and group P+F (p < 0.05). Entropy measures did not differ between groups. Conclusion: HRV analyses, including nonlinear methods, indicated that a K+X combination reduces imbalance and disorder in the regulation of the autonomic nervous system (ANS) in comparison to both P and the P+F combination.Article Citation - WoS: 3Citation - Scopus: 6Effects of Bevacizumab Administration on the Hypoxia- Induced Pulmonary Hypertension Rat Model(Tubitak Scientific & Technical Research Council Turkey, 2021-10-21) Demir, Canan; Karaman, Meral; Ucan, Eyup Sabri; Gokmen, Ali Necati; Gurel, Duygu; Coker, Sadiye Canan; Adali, Yasemen; Yilmaz, Osman; Gokmen, Necati; Coker, CananBackground/aim: Bevacizumab is a chemotherapeutic drug, which selectively binds to vascular endothelial growth factor (VEGF) and mainly inhibits angiogenesis and neovascularization. We aimed to study the possible effects of bevacizumab on right ventricular pressure (RVP), right ventricular hypertrophy, and VEGF, in hypoxia -induced pulmonary hypertension (PH) rat model. Materials and methods: 24 adult Wistar Albino rats were randomly divided into four groups: control group -saline; Bevacizumab Group; PH Group; PH + Bevacizumab Group. In hypoxia -induced model, 10% oxygen and 90% nitrogen were applied in a plexiglas box for eight days to PH Group and PH + Bevacizumab Group. On day eight, RVPs were measured directly from the heart, and then animals were sacrificed. Heart and lung tissues were examined, and Fulton index was measured. Results: RVP, Fulton index, and tissue VEGF scores were significantly lower in PH + Bevacizumab group than PH group: median (ranges), RVP, mmHg, 37.8 (33.0-39.0) and 32.3 (28.0-35.0), p: 0.01; Fulton index: 0.30 (0.29-0.33) and 0.25 (0.24-0.26), p: 0.003; tissue VEGF scores: 5.1 (4.8-5.3) and 4.0 (3.8 4.1), p: 0.004, respectively. Conclusion: Bevacizumab, which is indeed an antineoplastic agent, might have a favorable effect on hypoxia -induced pulmonary hypertension.Article Citation - WoS: 18Citation - Scopus: 23Urban and Rural Differences in Hypertension Risk Factors in Turkey(Aves, 2017) Dastan, Ilker; Erem, Ayşegül; Cetinkaya, VolkanObjective: Existing literature shows considerable regional differences in terms of hypertension (HT) prevalence in Turkey. The purpose of this study was to analyze some of the known HT risk factors contributing to the variations between urban and rural areas of Turkey in HT development. Methods: We used data from the 2011 Chronic Diseases and Risk Factors Survey that was conducted by the Turkish Ministry of Health on a representative sample of the Turkish adult population aged 20 years or more (n=16.227). HT was defined as having at least one of the following: a mean systolic/diastolic blood pressure of at least 140/90 mm Hg, a previously diagnosed disease, or use of antihypertensive medication. Stepwise multiple logistic regression analysis was used to estimate HT risk factors in urban and rural settings. Results: Although the HT prevalence was higher in rural areas (28.4%) than in urban areas (23.9%), in this study, urbanization was found to be a contributing factor in multivariate regression analysis. Furthermore, separate regressions for urban and rural settings revealed that age, obesity, diabetes, hyperlipidemia, and smoking were independently and positively associated (p<0.05) with HT in both settings, while marital status, employment type, mental health, and lifestyle patterns; nutritional habits; and amount of physical activity and sedentary time (p<0.05) were risk indicators in urban areas only. Conclusion: The findings of our study demonstrate that contributory factors show some variations between urban and rural settings, and on gender within each setting. Taking into account the variations between urban and rural areas in HT development may provide greater insight into the design of prevention strategies.