Şişman, Gizem

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Profile URL
https://hdl.handle.net/20.500.14365/7534
Name Variants
Sisman, Gizem
Job Title
Email Address
gizem.sisman@ieu.edu.tr
gizem.sisman88@gmail.com
Main Affiliation
15.04. Medical Imaging Techniques
Status
Current Staff
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ORCID ID
0000-0002-6134-9623
Scopus Author ID
57297879000
Turkish CoHE Profile ID
44210951F9BC51F6
Google Scholar ID
cIKlPAUAAAAJ
WoS Researcher ID
AAE-3671-2022
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GizemSisman.jpg (9.36 KB)

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Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi1
International Journal of Radiation Biology1
Journal of Basic and Clinical Health Sciences1
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  • Thumbnail Image
    Article
    Yeni Radyasyon Zırh Malzemelerinin Geliştirilmesi: Nadir Toprak Elementlerinin Rolü
    (2025) Şişman, Gizem; Yurt, Ayşegül; Akgungor, Kadir; Epik, Hakan; Kandemir, Recep
    Bismut ve Kurşun, radyasyonun neden olduğu zarar ve kanser riskini azaltmak için yaygın olarak kullanılan koruma malzemeleridir. Ancak bu malzemeler, maliyetli ve bazı uygulamalar için pratik değildir. Bu çalışma, Monte Carlo simülasyonları kullanılarak çeşitli element ve bileşiklerin zayıflatma özelliklerini inceleyerek daha iyi radyasyon koruma malzemeleri geliştirmeyi amaçlamaktadır. GAMOS yazılımı, 0.1 ila 2.0 mm arasında değişen kalınlıklara sahip malzemeler ve 10 ila 150 keV enerji aralığındaki x-ışınları için simülasyonlar yapmak üzere kullanılmıştır. İlk simülasyonlar, bismut ve kurşunun kütle zayıflatma katsayılarını hesaplayarak bu malzemeleri doğrulamaya odaklanmış ve elde edilen değerler, NIST’in (Ulusal Standartlar ve Teknoloji Enstitüsü) verileriyle %2’lik bir fark içinde uyuşmuştur. Doğrulama sonrası, metaller ve nadir toprak elementleri içeren çeşitli koruyucu malzemeler simüle edilmiştir. Bunlar arasından, en yüksek kütle zayıflatma katsayısına sahip dört nadir toprak elementi katkılı bileşik seçilmiştir. Sonuç olarak, bu bileşiklerin 50–80 keV enerji aralığında bismut ve kurşuna kıyasla daha yüksek bir absorpsiyon sağladığı görülmüştür.
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    Article
    Investigation of Glass Ceiling Syndrome Among Radiation Professionals: a Comparative Analysis
    (Dokuz Eylul Univ inst Health Sciences, 2025) Şişman, Gizem; Çilengiroğlu, Özgül Vupa; Alkan, Turkan
    Background and Purpose: This study investigates the perception of the glass ceiling syndrome among radiology, nuclear medicine, and radiation oncology technicians in healthcare institutions in Turkey. Methods: A comparative approach was used to examine the prevalence and impact of the glass ceiling on female workers. Data was collected via questionnaires from 311 participants in Turkey, and analyzed using descriptive statistics, chi-square analysis, and independent sample tests. Results: The results indicate that 78.1% of the participants were women, 64% were medical imaging technicians and 65.3% were employed in private institutions. A significant difference was found in the total and subscale scores of the glass ceiling scale (excluding mentoring) based on gender (p<0.05). Conclusion: This study enhances understanding of gender dynamics among radiation workers and highlights the need for targeted interventions to address the glass ceiling syndrome. The findings provide key insights for promoting workforce equity and organizational development in healthcare institutions.
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    Article
    Ionizing Radiation-Induced Testicular Oxidative Stress and Apoptosis: The Role of Small GTPase RhoA
    (Taylor & Francis Ltd, 2025) Manisaligil, Yasar Aysun; Yurt, Aysegul; Ozkan, Cemre Ural; Micili, Serap Cilaker; Sisman, Gizem; Cavdar, Zahide; Gumustekin, Mukaddes
    PurposeThe effects of ionizing radiation on living organisms are mainly known as the generation of reactive oxygen species (ROS), apoptosis, and DNA damage. Small GTPases (RhoA, Rac1, Cdc42) are known to have roles in the regulation of oxidative stress and apoptosis. The aim of this study was to investigate the role of the RhoA molecule in testicular tissue damage due to oxidative stress and apoptosis induced by ionizing radiation.Material and methodIn this study, testicular tissues and blood samples obtained from our previous study were examined. In that study, rats were exposed to ionizing radiation at three different doses (0.02 Gy, 0.1 Gy, 5 Gy). Then tissue and blood samples were taken at three different times (2 hours, 24 hours, and 7 days) after irradiation. Immunohistochemical staining was performed to evaluate RhoA and cleaved caspase-3 expressions, while RhoA activity was assessed by G-LISA assay in testicular tissues. Serum malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity were analyzed to evaluate oxidative stress.ResultsThe expression and activation of RhoA demonstrated a time-dependent increase across all levels of radiation doses. Similarly, the expression of cleaved caspase-3 also exhibited a time-dependent increase, consistent with the effects of radiation-induced damage observed in all experimental groups. After exposure to radiation, serum levels of MDA increased, while the activity of SOD decreased.ConclusionOur findings suggest that RhoA may contribute to radiation-induced testicular tissue damage by increasing oxidative stress and apoptosis.