Terbium-161 PSMA Therapy in mCRPC Patient Based on an Optimized Radiolabeling Protocol
| dc.contributor.author | Sezgin, Ceren | |
| dc.contributor.author | Uygur, Emre | |
| dc.contributor.author | Parlak, Yasemin | |
| dc.contributor.author | Karatay, Busra | |
| dc.contributor.author | Barutca, Sabri | |
| dc.contributor.author | Dirican, Ahmet | |
| dc.contributor.author | Gumuser, Gul | |
| dc.date.accessioned | 2025-09-25T19:00:32Z | |
| dc.date.available | 2025-09-25T19:00:32Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | This study presents a novel radiolabeling technique for [161Tb]-PSMA-617 in metastatic castration-resistant prostate cancer (mCRPC). The research focused on assessing the radiochemical yield, in vivo stability, and pharmacokinetics of [116 Tb]-PSMA-617 in a clinical setting. Using a sodium acetate buffer and ascorbic acid, a high radiochemical yield (97.98% +/- 2.01) was achieved, ensuring stability and purity. The therapy was evaluated to a 77-year-old mCRPC patient resistant to [177Lu]-PSMA-617, showing favorable biodistribution and urinary excretion. Despite initial stability, disease progression occurred, with a TP53 mutation identified via liquid biopsy. While the method holds promise for targeted radionuclide therapy, resistance mechanisms remain a challenge, necessitating further research for optimized patient selection and treatment strategies. | en_US |
| dc.identifier.doi | 10.1007/s10967-025-10352-3 | |
| dc.identifier.issn | 0236-5731 | |
| dc.identifier.issn | 1588-2780 | |
| dc.identifier.scopus | 2-s2.0-105014827723 | |
| dc.identifier.uri | https://doi.org/10.1007/s10967-025-10352-3 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14365/6430 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.relation.ispartof | Journal of Radioanalytical and Nuclear Chemistry | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Targeted Radionuclide Therapy | en_US |
| dc.subject | Prostate-Specific Membrane Antigen | en_US |
| dc.subject | Terbium-161 | en_US |
| dc.title | Terbium-161 PSMA Therapy in mCRPC Patient Based on an Optimized Radiolabeling Protocol | en_US |
| dc.type | Article | en_US |
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| gdc.description.department | İzmir Ekonomi Üniversitesi | en_US |
| gdc.description.departmenttemp | [Sezgin, Ceren] Manisa City Hosp, Dept Nucl Med, TR-45040 Manisa, Turkiye; [Uygur, Emre; Gumuser, Gul] Manisa Celal Bayar Univ, Biomed Device Technol, TR-45140 Manisa, Turkiye; [Parlak, Yasemin] Manisa Celal Bayar Univ, Sch Med, Dept Nucl Med, TR-45030 Manisa, Turkiye; [Karatay, Busra; Muftuler, Zumrut Biber] Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkiye; [Barutca, Sabri] Aydin Adnan Menderes Univ, Sch Med, Dept Med Oncol, TR-09100 Aydin, Turkiye; [Dirican, Ahmet] Izmir Univ Econ, Sch Med, Dept Med Oncol, TR-35330 Izmir, Turkiye; [Sozen, Tevfik Sinan] Gazi Univ, Sch Med, Dept Urol, TR-06500 Ankara, Turkiye; [Arslan, Guven] Dokuz Eylul Univ, Sch Med, Dept Urol, TR-35340 Izmir, Turkiye; [Harmansah, Coskun] Ege Univ, Ege Higher Vocat Sch, TR-35100 Izmir, Turkiye; [Toklu, Turkay] Yeditepe Univ, Inst Hlth Sci, TR-34755 Istanbul, Turkiye; [Avcibasi, Ugur] Manisa Celal Bayar Univ, Fac Arts & Sci, Dept Chem, TR-45140 Manisa, Turkiye; [Aras, Omer] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY USA; [Sezgin, Ceren] Manisa City Hosp, Dept Nucl Med, TR-45030 Manisa, Turkiye | en_US |
| gdc.description.endpage | 5988 | |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.startpage | 5979 | |
| gdc.description.volume | 334 | |
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