Synthesis and Characterization of Folic Acid-Chitosan Nanoparticles Loaded With Thymoquinone To Target Ovarian Cancer Cells
| dc.contributor.author | Ince, Iskender | |
| dc.contributor.author | Yildirim, Yeliz | |
| dc.contributor.author | Guler, Gunnur | |
| dc.contributor.author | Medine, Emin Ilker | |
| dc.contributor.author | Ballica, Gulsah | |
| dc.contributor.author | Kusdemir, Bekir Cem | |
| dc.contributor.author | Goker, Erdem | |
| dc.date.accessioned | 2023-06-16T12:48:02Z | |
| dc.date.available | 2023-06-16T12:48:02Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | The aim of the present research was to formulate and characterize radioiodinated folic acid-chitosan conjugated thymoquinone nanoparticles (FATQCSNPs) and to increase targeting ability on ovarian cancer cell. The dose of drug-loading into the FATQCSNPs and the amount of folic acid on the FATQCSNPs surface were determined as a 20.0 +/- 1% and 46.0 +/- 0.5%, respectively. Cell viabilities (%) determined on SKOV-3 and Caco-2 cells for 48 h. TQ, TQCS and FATQCS were very cytotoxic with lower IC50 values on both cell lines. At specific-activity-dependent incorporation study, the incorporation efficiencies of I-131-FATQCSNPs was higher than that of I-131-TQ on SKOV3 cell lines. | en_US |
| dc.identifier.doi | 10.1007/s10967-020-07058-z | |
| dc.identifier.issn | 0236-5731 | |
| dc.identifier.issn | 1588-2780 | |
| dc.identifier.scopus | 2-s2.0-85080987560 | |
| dc.identifier.uri | https://doi.org/10.1007/s10967-020-07058-z | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14365/940 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.relation.ispartof | Journal of Radıoanalytıcal And Nuclear Chemıstry | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Thymoquinone (TQ) | en_US |
| dc.subject | Chitosan nanoparticles | en_US |
| dc.subject | Folate-receptor-targeted | en_US |
| dc.subject | Ovarian cancer | en_US |
| dc.subject | Infrared-Spectroscopy | en_US |
| dc.subject | Ftir Spectroscopy | en_US |
| dc.subject | Folate Receptors | en_US |
| dc.subject | Drug-Delivery | en_US |
| dc.subject | Apoptosis | en_US |
| dc.subject | Inhibition | en_US |
| dc.subject | Protein | en_US |
| dc.subject | Agent | en_US |
| dc.title | Synthesis and Characterization of Folic Acid-Chitosan Nanoparticles Loaded With Thymoquinone To Target Ovarian Cancer Cells | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | YILDIRIM, Yeliz/0000-0002-3014-4510 | |
| gdc.author.id | Kusdemir, Bekir Cem/0000-0001-8905-5769 | |
| gdc.author.id | medine, emin ilker/0000-0003-0139-7110 | |
| gdc.author.scopusid | 6507731451 | |
| gdc.author.scopusid | 7003747438 | |
| gdc.author.scopusid | 37010966300 | |
| gdc.author.scopusid | 10739428000 | |
| gdc.author.scopusid | 57215504786 | |
| gdc.author.scopusid | 57215493815 | |
| gdc.author.scopusid | 26662691100 | |
| gdc.author.wosid | YILDIRIM, Yeliz/AAG-5559-2019 | |
| gdc.author.wosid | Medine, Emin İlker/GLS-0483-2022 | |
| gdc.author.wosid | Güler, Günnur/GLQ-7527-2022 | |
| gdc.author.wosid | yildirim, yeliz/AAT-9491-2021 | |
| gdc.author.wosid | Güler, Günnur/AAH-6852-2021 | |
| gdc.author.wosid | Kusdemir, Bekir Cem/ABG-6109-2021 | |
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| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
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| gdc.description.department | İzmir Ekonomi Üniversitesi | en_US |
| gdc.description.departmenttemp | [Ince, Iskender; Yildirim, Yeliz] Ege Univ, Ctr Drug R&D & Pharmacokinet Applicat ARGEFAR, Izmir, Turkey; [Ince, Iskender; Medine, Emin Ilker] Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey; [Yildirim, Yeliz; Ballica, Gulsah] Ege Univ, Fac Sci, Dept Chem, Izmir, Turkey; [Guler, Gunnur] Izmir Univ Econ, Fac Engn, Dept Biomed Engn, Izmir, Turkey; [Kusdemir, Bekir Cem] Ege Univ, Grad Sch Nat & Appl Sci, Dept Biotechnol, TR-35100 Izmir, Turkey; [Goker, Erdem] Ege Univ, Fac Med, Div Med Oncol, Izmir, Turkey | en_US |
| gdc.description.endpage | 85 | en_US |
| gdc.description.issue | 1 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q3 | |
| gdc.description.startpage | 71 | en_US |
| gdc.description.volume | 324 | en_US |
| gdc.description.wosquality | Q3 | |
| gdc.identifier.openalex | W3010165552 | |
| gdc.identifier.wos | WOS:000521842900007 | |
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| gdc.oaire.influence | 3.3561032E-9 | |
| gdc.oaire.isgreen | false | |
| gdc.oaire.keywords | Ovarian cancer | |
| gdc.oaire.keywords | Chitosan nanopArticles | |
| gdc.oaire.keywords | Chitosan nanoparticles | |
| gdc.oaire.keywords | Folate-receptor-targeted | |
| gdc.oaire.keywords | Thymoquinone (TQ) | |
| gdc.oaire.popularity | 3.331905E-8 | |
| gdc.oaire.publicfunded | false | |
| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 0303 health sciences | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
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| gdc.scopus.citedcount | 48 | |
| gdc.virtual.author | Güler, Günnur | |
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