Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/2587
Title: Role of the Microrna-29 Family in Fibrotic Skin Diseases
Authors: Harmancı, Duygu
Erkan, Erdogan Pekcan
Kocak, Ayse
Akdoğan, Gül
Keywords: microRNA-29 family
skin
fibrotic skin diseases
function
pathogenesis
Systemic-Sclerosis
Pulmonary-Fibrosis
Liver Fibrosis
Extracellular-Matrix
Hypertrophic Scars
Mir-29
Expression
Apoptosis
Pathway
Suppression
Publisher: Spandidos Publ Ltd
Abstract: Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor- signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non-coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR-29 family is associated with fibrotic diseases. The aim of the present review is to provide an up-to-date summary of current knowledge on the latest developments associated with the miR-29 family and fibrotic skin diseases.
URI: https://doi.org/10.3892/br.2017.900
https://hdl.handle.net/20.500.14365/2587
ISSN: 2049-9434
2049-9442
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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