Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/2612
Title: Effects of Bevacizumab Administration on the Hypoxia- Induced Pulmonary Hypertension Rat Model
Authors: Demir, Canan
Karaman, Meral
Ucan, Eyup Sabri
Gokmen, Ali Necati
Gurel, Duygu
Coker, Sadiye Canan
Adali, Yasemen
Keywords: Hypertension
pulmonary
bevacizumab
hypoxia
Endothelial Growth-Factor
Arterial-Hypertension
Vegf
Angiogenesis
Expression
Circulation
Inhibition
Molecules
Diagnosis
Receptor
Publisher: Tubitak Scientific & Technical Research Council Turkey
Abstract: Background/aim: Bevacizumab is a chemotherapeutic drug, which selectively binds to vascular endothelial growth factor (VEGF) and mainly inhibits angiogenesis and neovascularization. We aimed to study the possible effects of bevacizumab on right ventricular pressure (RVP), right ventricular hypertrophy, and VEGF, in hypoxia -induced pulmonary hypertension (PH) rat model. Materials and methods: 24 adult Wistar Albino rats were randomly divided into four groups: control group -saline; Bevacizumab Group; PH Group; PH + Bevacizumab Group. In hypoxia -induced model, 10% oxygen and 90% nitrogen were applied in a plexiglas box for eight days to PH Group and PH + Bevacizumab Group. On day eight, RVPs were measured directly from the heart, and then animals were sacrificed. Heart and lung tissues were examined, and Fulton index was measured. Results: RVP, Fulton index, and tissue VEGF scores were significantly lower in PH + Bevacizumab group than PH group: median (ranges), RVP, mmHg, 37.8 (33.0-39.0) and 32.3 (28.0-35.0), p: 0.01; Fulton index: 0.30 (0.29-0.33) and 0.25 (0.24-0.26), p: 0.003; tissue VEGF scores: 5.1 (4.8-5.3) and 4.0 (3.8 4.1), p: 0.004, respectively. Conclusion: Bevacizumab, which is indeed an antineoplastic agent, might have a favorable effect on hypoxia -induced pulmonary hypertension.
URI: https://doi.org/10.3906/sag-2101-76
https://search.trdizin.gov.tr/yayin/detay/479680
https://hdl.handle.net/20.500.14365/2612
ISSN: 1300-0144
1303-6165
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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