Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/3723
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dc.contributor.authorKaplan Y.C.-
dc.contributor.authorDemir O.-
dc.date.accessioned2023-06-16T15:03:05Z-
dc.date.available2023-06-16T15:03:05Z-
dc.date.issued2021-
dc.identifier.issn1570-159X-
dc.identifier.urihttps://doi.org/10.2174/1570159X19666210211150856-
dc.identifier.urihttps://hdl.handle.net/20.500.14365/3723-
dc.description.abstractIt is challenging to balance the fetal risks associated with the use of antiepileptic drugs (AEDs) against maternal and fetal risks of seizure worsening, and therefore it is very important to define and distinguish the possible risks entailed by different AEDs. This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin’ carbamazepine’ phenobarbital’ and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy. The review focuses on major and organ-specific malformations’ dose-dependent risks’ mono vs polytherapy’ and clinical pharmacokinetics. A discussion regarding the safety of AED use during breastfeeding is also provided. © 2021 Bentham Science Publishersen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofCurrent Neuropharmacologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiepilepticsen_US
dc.subjectBreastfeedingen_US
dc.subjectCarbamazepineen_US
dc.subjectLamotrigineen_US
dc.subjectLevetiracetamen_US
dc.subjectMajor malformationsen_US
dc.subjectPhenobarbitalen_US
dc.subjectPhenytoinen_US
dc.subjectPregnancyen_US
dc.subjectValproateen_US
dc.subjectcarbamazepineen_US
dc.subjectcytochrome P450 2B6en_US
dc.subjectcytochrome P450 2C9en_US
dc.subjectlamotrigineen_US
dc.subjectlevetiracetamen_US
dc.subjectphenobarbitalen_US
dc.subjectphenytoinen_US
dc.subjectvalproic aciden_US
dc.subjectanticonvulsive agenten_US
dc.subjectcarbamazepineen_US
dc.subjectlamotrigineen_US
dc.subjectlevetiracetamen_US
dc.subjectphenobarbitalen_US
dc.subjectphenytoinen_US
dc.subjectvalproic aciden_US
dc.subjectbody weight lossen_US
dc.subjectbreast feedingen_US
dc.subjectcardiovascular malformationen_US
dc.subjectcholestatic hepatitisen_US
dc.subjectcleft lipen_US
dc.subjectcongenital malformationen_US
dc.subjectdrug safetyen_US
dc.subjectfemaleen_US
dc.subjectgestational ageen_US
dc.subjecthumanen_US
dc.subjecthypospadiasen_US
dc.subjectleg inequalityen_US
dc.subjectliver injuryen_US
dc.subjectmonotherapyen_US
dc.subjectmuscle hypotoniaen_US
dc.subjectneural tubeen_US
dc.subjectpregnancyen_US
dc.subjectprevalenceen_US
dc.subjectReviewen_US
dc.subjectseizureen_US
dc.subjectspinal dysraphismen_US
dc.subjectbreast feedingen_US
dc.subjectepilepsyen_US
dc.subjectpregnancyen_US
dc.subjectpregnancy complicationen_US
dc.subjectAnticonvulsantsen_US
dc.subjectBreast Feedingen_US
dc.subjectCarbamazepineen_US
dc.subjectEpilepsyen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectLamotrigineen_US
dc.subjectLevetiracetamen_US
dc.subjectPhenobarbitalen_US
dc.subjectPhenytoinen_US
dc.subjectPregnancyen_US
dc.subjectPregnancy Complicationsen_US
dc.subjectValproic Aciden_US
dc.titleUse of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamot-E rigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implicationsen_US
dc.typeReviewen_US
dc.identifier.doi10.2174/1570159X19666210211150856-
dc.identifier.pmid33573557en_US
dc.identifier.scopus2-s2.0-85119579157en_US
dc.authorscopusid56541140000-
dc.identifier.volume19en_US
dc.identifier.issue11en_US
dc.identifier.startpage1805en_US
dc.identifier.endpage1824en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.scopusqualityQ1-
dc.identifier.wosqualityQ1-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeReview-
item.fulltextWith Fulltext-
item.languageiso639-1en-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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