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https://hdl.handle.net/20.500.14365/3723| Title: | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamot-E rigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications | Authors: | Kaplan Y.C. Demir O. |
Keywords: | Antiepileptics Breastfeeding Carbamazepine Lamotrigine Levetiracetam Major malformations Phenobarbital Phenytoin Pregnancy Valproate carbamazepine cytochrome P450 2B6 cytochrome P450 2C9 lamotrigine levetiracetam phenobarbital phenytoin valproic acid anticonvulsive agent carbamazepine lamotrigine levetiracetam phenobarbital phenytoin valproic acid body weight loss breast feeding cardiovascular malformation cholestatic hepatitis cleft lip congenital malformation drug safety female gestational age human hypospadias leg inequality liver injury monotherapy muscle hypotonia neural tube pregnancy prevalence Review seizure spinal dysraphism breast feeding epilepsy pregnancy pregnancy complication Anticonvulsants Breast Feeding Carbamazepine Epilepsy Female Humans Lamotrigine Levetiracetam Phenobarbital Phenytoin Pregnancy Pregnancy Complications Valproic Acid |
Publisher: | Bentham Science Publishers | Abstract: | It is challenging to balance the fetal risks associated with the use of antiepileptic drugs (AEDs) against maternal and fetal risks of seizure worsening, and therefore it is very important to define and distinguish the possible risks entailed by different AEDs. This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin’ carbamazepine’ phenobarbital’ and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy. The review focuses on major and organ-specific malformations’ dose-dependent risks’ mono vs polytherapy’ and clinical pharmacokinetics. A discussion regarding the safety of AED use during breastfeeding is also provided. © 2021 Bentham Science Publishers | URI: | https://doi.org/10.2174/1570159X19666210211150856 https://hdl.handle.net/20.500.14365/3723 |
ISSN: | 1570-159X |
| Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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