Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/4658
Title: Is the Clinical Course of Non-Arteritic Ischemic Optic Neuropathy Associated With Oxidative Damage and the Dynamics of the Antioxidant Response?
Authors: Engin, Kaya Nusret
Karagulle, Duygu Harmanci
Durmaz Engin, Ceren
Kant, Melis
Yaman, Aylin
Akış, Merve
Özel Yıldız, Sevda
Akdoğan, Gül
Keywords: 8-hydroxy-2'-deoxyguanosine
Non-arteritic anterior ischemic optic neuropathy
Stress
Oxidative
Vitamin B-12
Vitamin E
Alpha-Tocopherol
Vitamin-B12 Deficiency
Intestinal-Absorption
Acid Levels
Dna-Damage
Serum
Biomarkers
Glaucoma
Stress
(5's)-8,5'-Cyclo-2'-Deoxyadenosines
Publisher: Springer
Abstract: PurposeOxidative stress is known to be a decisive factor in the wide etiopathogenesis of optic neuropathy. This study aimed to comprehensively evaluate the interaction of optic neuropathy's clinical course with systemic oxidative damage and antioxidant response dynamics in a large series.MethodsThis case-controlled clinical study included 33 non-arteritic anterior ischemic optic neuropathy (NAION) patients and 32 healthy individuals. Extensive systemic oxidation profiles were statistically compared between the two groups, and correlations between the clinical and biochemical data in the study group were analyzed.ResultsVitamin E and malondialdehyde (MDA) levels were significantly higher in the study group. Significant correlations were observed in the analyses between clinical findings and oxidative stress parameters. Correlations between vitamin E and intraocular pressure (IOP), between B-12 and cup-to-disk ratio (c/d), between antioxidant glutathione and superoxide dismutase (SOD) enzyme systems, and between uric acid (UA) and age were found to be very significant. As significant correlations were found in either clinical and biochemical data or in oxidative stress parameters, correlations between vitamin E and cholesterol, MDA were found to be very significant.ConclusionsThis study not only supplies significant information regarding oxidative damage and antioxidant response in NAION, but also points out the specific interactions of neuromodulators, like vitamin E, in intracellular signaling pathways and regulation mechanisms. A better reading of these connections may help improve diagnosis, follow-ups and treatment criteria and strategies.
URI: https://doi.org/10.1007/s10792-023-02699-x
https://hdl.handle.net/20.500.14365/4658
ISSN: 0165-5701
1573-2630
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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