Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5357
Title: Exploring free amino acid profiles in CCHF patients: Implications for disease progression
Authors: Büyüktuna, S.A.
Yerlitaş, S.İ.
Zararsız, G.E.
Doğan, K.
Kablan, D.
Bağcı, G.
Özer, S.
Keywords: amino acid
Crimean-Congo hemorrhagic fever
LC-MS/MS
severity
alanine aminotransferase
alkaline phosphatase
amino acid
amylase
arginine
aspartate aminotransferase
creatine kinase
creatinine
ethanolamine
ferritin
gamma glutamyltransferase
glutamic acid
glutamine
histidine
immunoglobulin M
interleukin 6
lactate dehydrogenase
methionine
ornithine
phenylalanine
ribavirin
steroid
taurine
tyrosine
amino acid
biological marker
activated partial thromboplastin time
adult
amino acid metabolism
area under the curve
Article
biochemical analysis
blood clotting
controlled study
Crimean Congo hemorrhagic fever
diagnostic test accuracy study
disease exacerbation
disease severity
electrochemiluminescence
electrospray
enzyme linked immunosorbent assay
fasting blood glucose level
female
hematocrit
hemoglobin blood level
hepatomegaly
human
intensive care unit
leukocyte count
liquid chromatography-mass spectrometry
liver dysfunction
liver function test
lymphocyte count
major clinical study
male
metabolic reprogramming
multiple reaction monitoring
neutrophil count
platelet count
real time polymerase chain reaction
receiver operating characteristic
scoring system
severity grading score
virus infection
aged
liquid chromatography
metabolism
middle aged
tandem mass spectrometry
Adult
Aged
Amino Acids
Biomarkers
Chromatography, Liquid
Disease Progression
Female
Humans
Male
Middle Aged
Tandem Mass Spectrometry
Publisher: John Wiley and Sons Inc
Abstract: This study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus (CCHFV) infection and alterations in amino acid metabolism. Our primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease. © 2024 Wiley Periodicals LLC.
URI: https://doi.org/10.1002/jmv.29672
https://hdl.handle.net/20.500.14365/5357
ISSN: 0146-6615
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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