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https://hdl.handle.net/20.500.14365/5357| Title: | Exploring free amino acid profiles in CCHF patients: Implications for disease progression | Authors: | Büyüktuna, S.A. Yerlitaş, S.İ. Zararsız, G.E. Doğan, K. Kablan, D. Bağcı, G. Özer, S. |
Keywords: | amino acid Crimean-Congo hemorrhagic fever LC-MS/MS severity alanine aminotransferase alkaline phosphatase amino acid amylase arginine aspartate aminotransferase creatine kinase creatinine ethanolamine ferritin gamma glutamyltransferase glutamic acid glutamine histidine immunoglobulin M interleukin 6 lactate dehydrogenase methionine ornithine phenylalanine ribavirin steroid taurine tyrosine amino acid biological marker activated partial thromboplastin time adult amino acid metabolism area under the curve Article biochemical analysis blood clotting controlled study Crimean Congo hemorrhagic fever diagnostic test accuracy study disease exacerbation disease severity electrochemiluminescence electrospray enzyme linked immunosorbent assay fasting blood glucose level female hematocrit hemoglobin blood level hepatomegaly human intensive care unit leukocyte count liquid chromatography-mass spectrometry liver dysfunction liver function test lymphocyte count major clinical study male metabolic reprogramming multiple reaction monitoring neutrophil count platelet count real time polymerase chain reaction receiver operating characteristic scoring system severity grading score virus infection aged liquid chromatography metabolism middle aged tandem mass spectrometry Adult Aged Amino Acids Biomarkers Chromatography, Liquid Disease Progression Female Humans Male Middle Aged Tandem Mass Spectrometry |
Publisher: | John Wiley and Sons Inc | Abstract: | This study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus (CCHFV) infection and alterations in amino acid metabolism. Our primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease. © 2024 Wiley Periodicals LLC. | URI: | https://doi.org/10.1002/jmv.29672 https://hdl.handle.net/20.500.14365/5357 |
ISSN: | 0146-6615 |
| Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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